Nucleosome and ubiquitin position Set2 to methylate H3K36

Set2 methyltransferase catalyzes the lysine 36 methylation of histone H3 (H3K36me) and the enzyme is mutated in many cancers. The authors provide mechanistic insights into how Set2 methylates nucleosomes by determining the 3.8 Å cryo-EM structure of Set2 bound to a H2B ubiquitinated nucleosome core...

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Autores principales:	Silvija Bilokapic, Mario Halic
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0672ca4ad221431ba246d83969a70d64
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id	oai:doaj.org-article:0672ca4ad221431ba246d83969a70d64
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spelling	oai:doaj.org-article:0672ca4ad221431ba246d83969a70d642021-12-02T14:39:16ZNucleosome and ubiquitin position Set2 to methylate H3K3610.1038/s41467-019-11726-42041-1723https://doaj.org/article/0672ca4ad221431ba246d83969a70d642019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11726-4https://doaj.org/toc/2041-1723Set2 methyltransferase catalyzes the lysine 36 methylation of histone H3 (H3K36me) and the enzyme is mutated in many cancers. The authors provide mechanistic insights into how Set2 methylates nucleosomes by determining the 3.8 Å cryo-EM structure of Set2 bound to a H2B ubiquitinated nucleosome core particle.Silvija BilokapicMario HalicNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Silvija Bilokapic Mario Halic Nucleosome and ubiquitin position Set2 to methylate H3K36
description	Set2 methyltransferase catalyzes the lysine 36 methylation of histone H3 (H3K36me) and the enzyme is mutated in many cancers. The authors provide mechanistic insights into how Set2 methylates nucleosomes by determining the 3.8 Å cryo-EM structure of Set2 bound to a H2B ubiquitinated nucleosome core particle.
format	article
author	Silvija Bilokapic Mario Halic
author_facet	Silvija Bilokapic Mario Halic
author_sort	Silvija Bilokapic
title	Nucleosome and ubiquitin position Set2 to methylate H3K36
title_short	Nucleosome and ubiquitin position Set2 to methylate H3K36
title_full	Nucleosome and ubiquitin position Set2 to methylate H3K36
title_fullStr	Nucleosome and ubiquitin position Set2 to methylate H3K36
title_full_unstemmed	Nucleosome and ubiquitin position Set2 to methylate H3K36
title_sort	nucleosome and ubiquitin position set2 to methylate h3k36
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/0672ca4ad221431ba246d83969a70d64
work_keys_str_mv	AT silvijabilokapic nucleosomeandubiquitinpositionset2tomethylateh3k36 AT mariohalic nucleosomeandubiquitinpositionset2tomethylateh3k36
_version_	1718390635055022080

Nucleosome and ubiquitin position Set2 to methylate H3K36

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