Elite controllers: A heterogeneous group of HIV-infected patients

The exceptional group of ECs has been of great help, and will continue to provide invaluable insight with regard to reach a potential functional cure of HIV. However, there is no consensus on the immune correlates associated to this EC phenotype which preclude reaching a potential functional cure of...

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Autores principales:	María A. Navarrete-Muñoz, Clara Restrepo, José M. Benito, Norma Rallón
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2020
Materias:	functional cure elite controllers heterogeneity virological control immunological control clinical outcomes Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/067628ee7d614729a9bc03f9f294f5a5
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spelling	oai:doaj.org-article:067628ee7d614729a9bc03f9f294f5a52021-11-17T14:21:58ZElite controllers: A heterogeneous group of HIV-infected patients2150-55942150-560810.1080/21505594.2020.1788887https://doaj.org/article/067628ee7d614729a9bc03f9f294f5a52020-12-01T00:00:00Zhttp://dx.doi.org/10.1080/21505594.2020.1788887https://doaj.org/toc/2150-5594https://doaj.org/toc/2150-5608The exceptional group of ECs has been of great help, and will continue to provide invaluable insight with regard to reach a potential functional cure of HIV. However, there is no consensus on the immune correlates associated to this EC phenotype which preclude reaching a potential functional cure of HIV. The existing literature studying this population of individuals has indeed revealed that they are a very heterogeneous group regarding virological, immunological, and even clinical characteristics, and that among ECs only a very small proportion are homogeneous in terms of maintaining virological and immunological control in the long term (the so-called long-term elite controllers, LTECs). Thus, it is of pivotal relevance to identify the LTECs subjects and use them as the right model to redefine immune correlates of a truly functional cure. This review summarizes the evidence of the heterogeneity of HIV elite controllers (ECs) subjects in terms of virological, immunological and clinical outcomes, and the implications of this phenomenon to adequately consider this EC phenotype as the right model of a functional cure.María A. Navarrete-MuñozClara RestrepoJosé M. BenitoNorma RallónTaylor & Francis Grouparticlefunctional cureelite controllersheterogeneityvirological controlimmunological controlclinical outcomesInfectious and parasitic diseasesRC109-216ENVirulence, Vol 11, Iss 1, Pp 889-897 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	functional cure elite controllers heterogeneity virological control immunological control clinical outcomes Infectious and parasitic diseases RC109-216
spellingShingle	functional cure elite controllers heterogeneity virological control immunological control clinical outcomes Infectious and parasitic diseases RC109-216 María A. Navarrete-Muñoz Clara Restrepo José M. Benito Norma Rallón Elite controllers: A heterogeneous group of HIV-infected patients
description	The exceptional group of ECs has been of great help, and will continue to provide invaluable insight with regard to reach a potential functional cure of HIV. However, there is no consensus on the immune correlates associated to this EC phenotype which preclude reaching a potential functional cure of HIV. The existing literature studying this population of individuals has indeed revealed that they are a very heterogeneous group regarding virological, immunological, and even clinical characteristics, and that among ECs only a very small proportion are homogeneous in terms of maintaining virological and immunological control in the long term (the so-called long-term elite controllers, LTECs). Thus, it is of pivotal relevance to identify the LTECs subjects and use them as the right model to redefine immune correlates of a truly functional cure. This review summarizes the evidence of the heterogeneity of HIV elite controllers (ECs) subjects in terms of virological, immunological and clinical outcomes, and the implications of this phenomenon to adequately consider this EC phenotype as the right model of a functional cure.
format	article
author	María A. Navarrete-Muñoz Clara Restrepo José M. Benito Norma Rallón
author_facet	María A. Navarrete-Muñoz Clara Restrepo José M. Benito Norma Rallón
author_sort	María A. Navarrete-Muñoz
title	Elite controllers: A heterogeneous group of HIV-infected patients
title_short	Elite controllers: A heterogeneous group of HIV-infected patients
title_full	Elite controllers: A heterogeneous group of HIV-infected patients
title_fullStr	Elite controllers: A heterogeneous group of HIV-infected patients
title_full_unstemmed	Elite controllers: A heterogeneous group of HIV-infected patients
title_sort	elite controllers: a heterogeneous group of hiv-infected patients
publisher	Taylor & Francis Group
publishDate	2020
url	https://doaj.org/article/067628ee7d614729a9bc03f9f294f5a5
work_keys_str_mv	AT mariaanavarretemunoz elitecontrollersaheterogeneousgroupofhivinfectedpatients AT clararestrepo elitecontrollersaheterogeneousgroupofhivinfectedpatients AT josembenito elitecontrollersaheterogeneousgroupofhivinfectedpatients AT normarallon elitecontrollersaheterogeneousgroupofhivinfectedpatients
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Elite controllers: A heterogeneous group of HIV-infected patients

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