Association of APOE4 genotype and treatment with cognitive outcomes in breast cancer survivors over time

Abstract This prospective longitudinal study of breast cancer survivors (n = 167) examined the association of apolipoprotein ε4 (APOE ε4) genotype with cognition and interactions with chemotherapy or endocrine therapy up to 6 years after treatment. In general, we found no effects of ε4 across timepo...

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Autores principales:	Kathleen Van Dyk, Catherine M. Crespi, Julienne E. Bower, Judith E. Carroll, Laura Petersen, Patricia A. Ganz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/0678e84df58a4c1084b1d3fc28820c5b
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spelling	oai:doaj.org-article:0678e84df58a4c1084b1d3fc28820c5b2021-12-02T19:10:22ZAssociation of APOE4 genotype and treatment with cognitive outcomes in breast cancer survivors over time10.1038/s41523-021-00327-42374-4677https://doaj.org/article/0678e84df58a4c1084b1d3fc28820c5b2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41523-021-00327-4https://doaj.org/toc/2374-4677Abstract This prospective longitudinal study of breast cancer survivors (n = 167) examined the association of apolipoprotein ε4 (APOE ε4) genotype with cognition and interactions with chemotherapy or endocrine therapy up to 6 years after treatment. In general, we found no effects of ε4 across timepoints and treatment exposures; post hoc analysis at 3–6 years suggested a trend towards worse cognition in the domains of attention and learning among ε4 carriers exposed to endocrine therapy. Further study is needed.Kathleen Van DykCatherine M. CrespiJulienne E. BowerJudith E. CarrollLaura PetersenPatricia A. GanzNature PortfolioarticleNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENnpj Breast Cancer, Vol 7, Iss 1, Pp 1-4 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Kathleen Van Dyk Catherine M. Crespi Julienne E. Bower Judith E. Carroll Laura Petersen Patricia A. Ganz Association of APOE4 genotype and treatment with cognitive outcomes in breast cancer survivors over time
description	Abstract This prospective longitudinal study of breast cancer survivors (n = 167) examined the association of apolipoprotein ε4 (APOE ε4) genotype with cognition and interactions with chemotherapy or endocrine therapy up to 6 years after treatment. In general, we found no effects of ε4 across timepoints and treatment exposures; post hoc analysis at 3–6 years suggested a trend towards worse cognition in the domains of attention and learning among ε4 carriers exposed to endocrine therapy. Further study is needed.
format	article
author	Kathleen Van Dyk Catherine M. Crespi Julienne E. Bower Judith E. Carroll Laura Petersen Patricia A. Ganz
author_facet	Kathleen Van Dyk Catherine M. Crespi Julienne E. Bower Judith E. Carroll Laura Petersen Patricia A. Ganz
author_sort	Kathleen Van Dyk
title	Association of APOE4 genotype and treatment with cognitive outcomes in breast cancer survivors over time
title_short	Association of APOE4 genotype and treatment with cognitive outcomes in breast cancer survivors over time
title_full	Association of APOE4 genotype and treatment with cognitive outcomes in breast cancer survivors over time
title_fullStr	Association of APOE4 genotype and treatment with cognitive outcomes in breast cancer survivors over time
title_full_unstemmed	Association of APOE4 genotype and treatment with cognitive outcomes in breast cancer survivors over time
title_sort	association of apoe4 genotype and treatment with cognitive outcomes in breast cancer survivors over time
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0678e84df58a4c1084b1d3fc28820c5b
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Association of APOE4 genotype and treatment with cognitive outcomes in breast cancer survivors over time

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