Laccase-Catalyzed Derivatization of Antibiotics with Sulfonamide or Sulfone Structures
<i>Trametes</i> spec. laccase (EC 1.10.3.2.) mediates the oxidative coupling of antibiotics with sulfonamide or sulfone structures with 2,5-dihydroxybenzene derivatives to form new heterodimers and heterotrimers. These heteromolecular hybrid products are formed by nuclear amination of th...
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MDPI AG
2021
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oai:doaj.org-article:0679829a7f6d4486b985f419f0c370672021-11-25T18:24:10ZLaccase-Catalyzed Derivatization of Antibiotics with Sulfonamide or Sulfone Structures10.3390/microorganisms91121992076-2607https://doaj.org/article/0679829a7f6d4486b985f419f0c370672021-10-01T00:00:00Zhttps://www.mdpi.com/2076-2607/9/11/2199https://doaj.org/toc/2076-2607<i>Trametes</i> spec. laccase (EC 1.10.3.2.) mediates the oxidative coupling of antibiotics with sulfonamide or sulfone structures with 2,5-dihydroxybenzene derivatives to form new heterodimers and heterotrimers. These heteromolecular hybrid products are formed by nuclear amination of the <i>p</i>-hydroquinones with the primary amino group of the sulfonamide or sulfone antibiotics, and they inhibited in vitro the growth of <i>Staphylococcus</i> species, including multidrug-resistant strains.Annett MikolaschVeronika HahnMDPI AGarticlelaccasebiotransformationsulfonamide antibioticsantibacterial activitymultidrug resistance (MDR)β-lactam antibioticsBiology (General)QH301-705.5ENMicroorganisms, Vol 9, Iss 2199, p 2199 (2021) |
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DOAJ |
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EN |
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laccase biotransformation sulfonamide antibiotics antibacterial activity multidrug resistance (MDR) β-lactam antibiotics Biology (General) QH301-705.5 |
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laccase biotransformation sulfonamide antibiotics antibacterial activity multidrug resistance (MDR) β-lactam antibiotics Biology (General) QH301-705.5 Annett Mikolasch Veronika Hahn Laccase-Catalyzed Derivatization of Antibiotics with Sulfonamide or Sulfone Structures |
description |
<i>Trametes</i> spec. laccase (EC 1.10.3.2.) mediates the oxidative coupling of antibiotics with sulfonamide or sulfone structures with 2,5-dihydroxybenzene derivatives to form new heterodimers and heterotrimers. These heteromolecular hybrid products are formed by nuclear amination of the <i>p</i>-hydroquinones with the primary amino group of the sulfonamide or sulfone antibiotics, and they inhibited in vitro the growth of <i>Staphylococcus</i> species, including multidrug-resistant strains. |
format |
article |
author |
Annett Mikolasch Veronika Hahn |
author_facet |
Annett Mikolasch Veronika Hahn |
author_sort |
Annett Mikolasch |
title |
Laccase-Catalyzed Derivatization of Antibiotics with Sulfonamide or Sulfone Structures |
title_short |
Laccase-Catalyzed Derivatization of Antibiotics with Sulfonamide or Sulfone Structures |
title_full |
Laccase-Catalyzed Derivatization of Antibiotics with Sulfonamide or Sulfone Structures |
title_fullStr |
Laccase-Catalyzed Derivatization of Antibiotics with Sulfonamide or Sulfone Structures |
title_full_unstemmed |
Laccase-Catalyzed Derivatization of Antibiotics with Sulfonamide or Sulfone Structures |
title_sort |
laccase-catalyzed derivatization of antibiotics with sulfonamide or sulfone structures |
publisher |
MDPI AG |
publishDate |
2021 |
url |
https://doaj.org/article/0679829a7f6d4486b985f419f0c37067 |
work_keys_str_mv |
AT annettmikolasch laccasecatalyzedderivatizationofantibioticswithsulfonamideorsulfonestructures AT veronikahahn laccasecatalyzedderivatizationofantibioticswithsulfonamideorsulfonestructures |
_version_ |
1718411176009793536 |