Laccase-Catalyzed Derivatization of Antibiotics with Sulfonamide or Sulfone Structures

<i>Trametes</i> spec. laccase (EC 1.10.3.2.) mediates the oxidative coupling of antibiotics with sulfonamide or sulfone structures with 2,5-dihydroxybenzene derivatives to form new heterodimers and heterotrimers. These heteromolecular hybrid products are formed by nuclear amination of th...

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Autores principales: Annett Mikolasch, Veronika Hahn
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Publicado: MDPI AG 2021
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Acceso en línea:https://doaj.org/article/0679829a7f6d4486b985f419f0c37067
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spelling oai:doaj.org-article:0679829a7f6d4486b985f419f0c370672021-11-25T18:24:10ZLaccase-Catalyzed Derivatization of Antibiotics with Sulfonamide or Sulfone Structures10.3390/microorganisms91121992076-2607https://doaj.org/article/0679829a7f6d4486b985f419f0c370672021-10-01T00:00:00Zhttps://www.mdpi.com/2076-2607/9/11/2199https://doaj.org/toc/2076-2607<i>Trametes</i> spec. laccase (EC 1.10.3.2.) mediates the oxidative coupling of antibiotics with sulfonamide or sulfone structures with 2,5-dihydroxybenzene derivatives to form new heterodimers and heterotrimers. These heteromolecular hybrid products are formed by nuclear amination of the <i>p</i>-hydroquinones with the primary amino group of the sulfonamide or sulfone antibiotics, and they inhibited in vitro the growth of <i>Staphylococcus</i> species, including multidrug-resistant strains.Annett MikolaschVeronika HahnMDPI AGarticlelaccasebiotransformationsulfonamide antibioticsantibacterial activitymultidrug resistance (MDR)β-lactam antibioticsBiology (General)QH301-705.5ENMicroorganisms, Vol 9, Iss 2199, p 2199 (2021)
institution DOAJ
collection DOAJ
language EN
topic laccase
biotransformation
sulfonamide antibiotics
antibacterial activity
multidrug resistance (MDR)
β-lactam antibiotics
Biology (General)
QH301-705.5
spellingShingle laccase
biotransformation
sulfonamide antibiotics
antibacterial activity
multidrug resistance (MDR)
β-lactam antibiotics
Biology (General)
QH301-705.5
Annett Mikolasch
Veronika Hahn
Laccase-Catalyzed Derivatization of Antibiotics with Sulfonamide or Sulfone Structures
description <i>Trametes</i> spec. laccase (EC 1.10.3.2.) mediates the oxidative coupling of antibiotics with sulfonamide or sulfone structures with 2,5-dihydroxybenzene derivatives to form new heterodimers and heterotrimers. These heteromolecular hybrid products are formed by nuclear amination of the <i>p</i>-hydroquinones with the primary amino group of the sulfonamide or sulfone antibiotics, and they inhibited in vitro the growth of <i>Staphylococcus</i> species, including multidrug-resistant strains.
format article
author Annett Mikolasch
Veronika Hahn
author_facet Annett Mikolasch
Veronika Hahn
author_sort Annett Mikolasch
title Laccase-Catalyzed Derivatization of Antibiotics with Sulfonamide or Sulfone Structures
title_short Laccase-Catalyzed Derivatization of Antibiotics with Sulfonamide or Sulfone Structures
title_full Laccase-Catalyzed Derivatization of Antibiotics with Sulfonamide or Sulfone Structures
title_fullStr Laccase-Catalyzed Derivatization of Antibiotics with Sulfonamide or Sulfone Structures
title_full_unstemmed Laccase-Catalyzed Derivatization of Antibiotics with Sulfonamide or Sulfone Structures
title_sort laccase-catalyzed derivatization of antibiotics with sulfonamide or sulfone structures
publisher MDPI AG
publishDate 2021
url https://doaj.org/article/0679829a7f6d4486b985f419f0c37067
work_keys_str_mv AT annettmikolasch laccasecatalyzedderivatizationofantibioticswithsulfonamideorsulfonestructures
AT veronikahahn laccasecatalyzedderivatizationofantibioticswithsulfonamideorsulfonestructures
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