TNF-α-mediated m6A modification of ELMO1 triggers directional migration of mesenchymal stem cell in ankylosing spondylitis

TNF-α-mediated m6A modification of ELMO1 triggers directional migration of mesenchymal stem cell in ankylosing spondylitis

Abnormal functions of mesenchymal stem cells (MSC) contribute into the pathogenensis of ankylosing spondylitis (AS). Here, the authors show that TNF-α at high concentration induces enhances migration of AS-MSC through METTL14 mediated m6A modification of the ELMO1 3′ UTR.

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Autores principales: Zhongyu Xie, Wenhui Yu, Guan Zheng, Jinteng Li, Shuizhong Cen, Guiwen Ye, Zhaofeng Li, Wenjie Liu, Ming Li, Jiajie Lin, Zepeng Su, Yunshu Che, Feng Ye, Peng Wang, Yanfeng Wu, Huiyong Shen
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Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/067988a62b144222ad81c6a027ce6550
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spelling oai:doaj.org-article:067988a62b144222ad81c6a027ce65502021-12-02T14:55:09ZTNF-α-mediated m6A modification of ELMO1 triggers directional migration of mesenchymal stem cell in ankylosing spondylitis10.1038/s41467-021-25710-42041-1723https://doaj.org/article/067988a62b144222ad81c6a027ce65502021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25710-4https://doaj.org/toc/2041-1723Abnormal functions of mesenchymal stem cells (MSC) contribute into the pathogenensis of ankylosing spondylitis (AS). Here, the authors show that TNF-α at high concentration induces enhances migration of AS-MSC through METTL14 mediated m6A modification of the ELMO1 3′ UTR.Zhongyu XieWenhui YuGuan ZhengJinteng LiShuizhong CenGuiwen YeZhaofeng LiWenjie LiuMing LiJiajie LinZepeng SuYunshu CheFeng YePeng WangYanfeng WuHuiyong ShenNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Zhongyu Xie
Wenhui Yu
Guan Zheng
Jinteng Li
Shuizhong Cen
Guiwen Ye
Zhaofeng Li
Wenjie Liu
Ming Li
Jiajie Lin
Zepeng Su
Yunshu Che
Feng Ye
Peng Wang
Yanfeng Wu
Huiyong Shen
TNF-α-mediated m6A modification of ELMO1 triggers directional migration of mesenchymal stem cell in ankylosing spondylitis
description Abnormal functions of mesenchymal stem cells (MSC) contribute into the pathogenensis of ankylosing spondylitis (AS). Here, the authors show that TNF-α at high concentration induces enhances migration of AS-MSC through METTL14 mediated m6A modification of the ELMO1 3′ UTR.
format article
author Zhongyu Xie
Wenhui Yu
Guan Zheng
Jinteng Li
Shuizhong Cen
Guiwen Ye
Zhaofeng Li
Wenjie Liu
Ming Li
Jiajie Lin
Zepeng Su
Yunshu Che
Feng Ye
Peng Wang
Yanfeng Wu
Huiyong Shen
author_facet Zhongyu Xie
Wenhui Yu
Guan Zheng
Jinteng Li
Shuizhong Cen
Guiwen Ye
Zhaofeng Li
Wenjie Liu
Ming Li
Jiajie Lin
Zepeng Su
Yunshu Che
Feng Ye
Peng Wang
Yanfeng Wu
Huiyong Shen
author_sort Zhongyu Xie
title TNF-α-mediated m6A modification of ELMO1 triggers directional migration of mesenchymal stem cell in ankylosing spondylitis
title_short TNF-α-mediated m6A modification of ELMO1 triggers directional migration of mesenchymal stem cell in ankylosing spondylitis
title_full TNF-α-mediated m6A modification of ELMO1 triggers directional migration of mesenchymal stem cell in ankylosing spondylitis
title_fullStr TNF-α-mediated m6A modification of ELMO1 triggers directional migration of mesenchymal stem cell in ankylosing spondylitis
title_full_unstemmed TNF-α-mediated m6A modification of ELMO1 triggers directional migration of mesenchymal stem cell in ankylosing spondylitis
title_sort tnf-α-mediated m6a modification of elmo1 triggers directional migration of mesenchymal stem cell in ankylosing spondylitis
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/067988a62b144222ad81c6a027ce6550
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