Longitudinal impact of bladder cancer diagnosis on common psychiatric disorders

Abstract Background The presence of psychiatric disorders in patients with cancer is associated with increased morbidity and poorer outcomes. We sought to determine the impact of a new bladder cancer diagnosis on the incidence of depression and anxiety. Methods We used a database of billing claims (...

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Autores principales:	Ian J. Cooke, Dattatraya Patil, Katherine Bobrek, Vikram Narayan, Viraj Master, Mark Rapaport, Christopher P. Filson, Shreyas S. Joshi
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	bladder cancer cancer survivorship mental health Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/067a8cc166f5435f90ddfa3e652c0f56
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spelling	oai:doaj.org-article:067a8cc166f5435f90ddfa3e652c0f562021-12-01T04:49:15ZLongitudinal impact of bladder cancer diagnosis on common psychiatric disorders2045-763410.1002/cam4.4346https://doaj.org/article/067a8cc166f5435f90ddfa3e652c0f562021-12-01T00:00:00Zhttps://doi.org/10.1002/cam4.4346https://doaj.org/toc/2045-7634Abstract Background The presence of psychiatric disorders in patients with cancer is associated with increased morbidity and poorer outcomes. We sought to determine the impact of a new bladder cancer diagnosis on the incidence of depression and anxiety. Methods We used a database of billing claims (MarketScan®) to identify patients newly diagnosed with bladder cancer between 2009 and 2018. Patients with preexisting psychiatric disorders or use of anxiolytics/antidepressants were excluded. We matched cases to patients without a bladder cancer or psychiatric diagnosis. Our primary outcome was a new diagnosis of depression, anxiety, or use of anxiolytics/antidepressants. Other exposures of interest included gender and treatment received. We used multivariable regression to estimate odds ratios for these exposures. Results We identified 65,846 cases with a new diagnosis of bladder cancer (31,367 privately insured; 34,479 Medicare‐eligible). Compared to controls, bladder cancer patients were more likely to develop new‐onset depression/anxiety at 6 months (privately insured: 6.9% vs. 3.4%, p < 0.001; Medicare‐eligible: 5.7% vs. 3.4%, p < 0.001) and 36 months (privately insured: 19.2% vs. 13.5%, p < 0.001; Medicare‐eligible: 19.3% vs. 16.0%, p < 0.001). Women (vs. men, privately insured: OR 1.65, 95%CI 1.53–1.78; Medicare‐eligible: OR 1.63, 95%CI 1.50–1.76) and those receiving cystectomy and chemotherapy (vs. no treatment, privately insured: OR 4.94, 95%CI 4.13–5.90; Medicare‐eligible: OR 2.35, 95%CI 1.88–2.94) were more likely to develop significant depression/anxiety. Conclusion A new diagnosis of bladder cancer was associated with increased burden of significant depression/anxiety compared with matched controls. Women and patients receiving more radical treatments had higher rates of depression and anxiety.Ian J. CookeDattatraya PatilKatherine BobrekVikram NarayanViraj MasterMark RapaportChristopher P. FilsonShreyas S. JoshiWileyarticlebladder cancercancer survivorshipmental healthNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancer Medicine, Vol 10, Iss 23, Pp 8412-8420 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	bladder cancer cancer survivorship mental health Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	bladder cancer cancer survivorship mental health Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Ian J. Cooke Dattatraya Patil Katherine Bobrek Vikram Narayan Viraj Master Mark Rapaport Christopher P. Filson Shreyas S. Joshi Longitudinal impact of bladder cancer diagnosis on common psychiatric disorders
description	Abstract Background The presence of psychiatric disorders in patients with cancer is associated with increased morbidity and poorer outcomes. We sought to determine the impact of a new bladder cancer diagnosis on the incidence of depression and anxiety. Methods We used a database of billing claims (MarketScan®) to identify patients newly diagnosed with bladder cancer between 2009 and 2018. Patients with preexisting psychiatric disorders or use of anxiolytics/antidepressants were excluded. We matched cases to patients without a bladder cancer or psychiatric diagnosis. Our primary outcome was a new diagnosis of depression, anxiety, or use of anxiolytics/antidepressants. Other exposures of interest included gender and treatment received. We used multivariable regression to estimate odds ratios for these exposures. Results We identified 65,846 cases with a new diagnosis of bladder cancer (31,367 privately insured; 34,479 Medicare‐eligible). Compared to controls, bladder cancer patients were more likely to develop new‐onset depression/anxiety at 6 months (privately insured: 6.9% vs. 3.4%, p < 0.001; Medicare‐eligible: 5.7% vs. 3.4%, p < 0.001) and 36 months (privately insured: 19.2% vs. 13.5%, p < 0.001; Medicare‐eligible: 19.3% vs. 16.0%, p < 0.001). Women (vs. men, privately insured: OR 1.65, 95%CI 1.53–1.78; Medicare‐eligible: OR 1.63, 95%CI 1.50–1.76) and those receiving cystectomy and chemotherapy (vs. no treatment, privately insured: OR 4.94, 95%CI 4.13–5.90; Medicare‐eligible: OR 2.35, 95%CI 1.88–2.94) were more likely to develop significant depression/anxiety. Conclusion A new diagnosis of bladder cancer was associated with increased burden of significant depression/anxiety compared with matched controls. Women and patients receiving more radical treatments had higher rates of depression and anxiety.
format	article
author	Ian J. Cooke Dattatraya Patil Katherine Bobrek Vikram Narayan Viraj Master Mark Rapaport Christopher P. Filson Shreyas S. Joshi
author_facet	Ian J. Cooke Dattatraya Patil Katherine Bobrek Vikram Narayan Viraj Master Mark Rapaport Christopher P. Filson Shreyas S. Joshi
author_sort	Ian J. Cooke
title	Longitudinal impact of bladder cancer diagnosis on common psychiatric disorders
title_short	Longitudinal impact of bladder cancer diagnosis on common psychiatric disorders
title_full	Longitudinal impact of bladder cancer diagnosis on common psychiatric disorders
title_fullStr	Longitudinal impact of bladder cancer diagnosis on common psychiatric disorders
title_full_unstemmed	Longitudinal impact of bladder cancer diagnosis on common psychiatric disorders
title_sort	longitudinal impact of bladder cancer diagnosis on common psychiatric disorders
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/067a8cc166f5435f90ddfa3e652c0f56
work_keys_str_mv	AT ianjcooke longitudinalimpactofbladdercancerdiagnosisoncommonpsychiatricdisorders AT dattatrayapatil longitudinalimpactofbladdercancerdiagnosisoncommonpsychiatricdisorders AT katherinebobrek longitudinalimpactofbladdercancerdiagnosisoncommonpsychiatricdisorders AT vikramnarayan longitudinalimpactofbladdercancerdiagnosisoncommonpsychiatricdisorders AT virajmaster longitudinalimpactofbladdercancerdiagnosisoncommonpsychiatricdisorders AT markrapaport longitudinalimpactofbladdercancerdiagnosisoncommonpsychiatricdisorders AT christopherpfilson longitudinalimpactofbladdercancerdiagnosisoncommonpsychiatricdisorders AT shreyassjoshi longitudinalimpactofbladdercancerdiagnosisoncommonpsychiatricdisorders
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Longitudinal impact of bladder cancer diagnosis on common psychiatric disorders

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