Chronic Milk-Dependent Food Protein-Induced Enterocolitis Syndrome in Children from West Pomerania Region

Characteristics of chronic milk-dependent food protein-induced enterocolitis syndrome (FPIES) in children from the region of Western Pomerania were studied. Prospectively, 55 children were diagnosed at a median of 2.2 months. The open food challenges (OFC), morphologies, milk-specific IgE (sIgE) (FE...

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Autores principales:	Karolina Bulsa, Małgorzata Standowicz, Elżbieta Baryła-Pankiewicz, Grażyna Czaja-Bulsa
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	milk allergy children non-IgE mediated CMA food protein-induced enterocolitis syndrome FPIES Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/067e21d101b94b498b181addace3d8cd
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spelling	oai:doaj.org-article:067e21d101b94b498b181addace3d8cd2021-11-25T18:37:02ZChronic Milk-Dependent Food Protein-Induced Enterocolitis Syndrome in Children from West Pomerania Region10.3390/nu131141372072-6643https://doaj.org/article/067e21d101b94b498b181addace3d8cd2021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/4137https://doaj.org/toc/2072-6643Characteristics of chronic milk-dependent food protein-induced enterocolitis syndrome (FPIES) in children from the region of Western Pomerania were studied. Prospectively, 55 children were diagnosed at a median of 2.2 months. The open food challenges (OFC), morphologies, milk-specific IgE (sIgE) (FEIA method, CAP system), and skin prick tests (SPTs) were examined. Vomiting and diarrhea escalated gradually but quickly led to growth retardation. Of the infants, 49% had BMI < 10 c, 20% BMI < 3 c; 25% had anemia, and 15% had hypoalbuminemia. During the OFCs we observed acute symptoms that appeared after 2–3 h: vomiting diarrhea and pallor. A total of 42% children required intravenous hydration. Casein hydrolysates or amino acids formulae (20%) were used in treatment. In 25% of children, SPT and milk sIgE were found, in 18%—other food SPTs, and in 14% allergy to other foods. A transition to IgE-dependent milk allergy was seen in 3 children. In the twelfth month of life, 62% of children had tolerance to milk, and in the twenty-fifth month—87%. Conclusions. Chronic milk-dependent FPIES resolves in most children. By the age of 2 children are at risk of multiple food sensitization, and those who have milk sIgE are at risk to transition to IgE-mediated milk allergy. Every OFC needs to be supervised due to possible severe reactions.Karolina BulsaMałgorzata StandowiczElżbieta Baryła-PankiewiczGrażyna Czaja-BulsaMDPI AGarticlemilk allergychildrennon-IgE mediated CMAfood protein-induced enterocolitis syndromeFPIESNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 4137, p 4137 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	milk allergy children non-IgE mediated CMA food protein-induced enterocolitis syndrome FPIES Nutrition. Foods and food supply TX341-641
spellingShingle	milk allergy children non-IgE mediated CMA food protein-induced enterocolitis syndrome FPIES Nutrition. Foods and food supply TX341-641 Karolina Bulsa Małgorzata Standowicz Elżbieta Baryła-Pankiewicz Grażyna Czaja-Bulsa Chronic Milk-Dependent Food Protein-Induced Enterocolitis Syndrome in Children from West Pomerania Region
description	Characteristics of chronic milk-dependent food protein-induced enterocolitis syndrome (FPIES) in children from the region of Western Pomerania were studied. Prospectively, 55 children were diagnosed at a median of 2.2 months. The open food challenges (OFC), morphologies, milk-specific IgE (sIgE) (FEIA method, CAP system), and skin prick tests (SPTs) were examined. Vomiting and diarrhea escalated gradually but quickly led to growth retardation. Of the infants, 49% had BMI < 10 c, 20% BMI < 3 c; 25% had anemia, and 15% had hypoalbuminemia. During the OFCs we observed acute symptoms that appeared after 2–3 h: vomiting diarrhea and pallor. A total of 42% children required intravenous hydration. Casein hydrolysates or amino acids formulae (20%) were used in treatment. In 25% of children, SPT and milk sIgE were found, in 18%—other food SPTs, and in 14% allergy to other foods. A transition to IgE-dependent milk allergy was seen in 3 children. In the twelfth month of life, 62% of children had tolerance to milk, and in the twenty-fifth month—87%. Conclusions. Chronic milk-dependent FPIES resolves in most children. By the age of 2 children are at risk of multiple food sensitization, and those who have milk sIgE are at risk to transition to IgE-mediated milk allergy. Every OFC needs to be supervised due to possible severe reactions.
format	article
author	Karolina Bulsa Małgorzata Standowicz Elżbieta Baryła-Pankiewicz Grażyna Czaja-Bulsa
author_facet	Karolina Bulsa Małgorzata Standowicz Elżbieta Baryła-Pankiewicz Grażyna Czaja-Bulsa
author_sort	Karolina Bulsa
title	Chronic Milk-Dependent Food Protein-Induced Enterocolitis Syndrome in Children from West Pomerania Region
title_short	Chronic Milk-Dependent Food Protein-Induced Enterocolitis Syndrome in Children from West Pomerania Region
title_full	Chronic Milk-Dependent Food Protein-Induced Enterocolitis Syndrome in Children from West Pomerania Region
title_fullStr	Chronic Milk-Dependent Food Protein-Induced Enterocolitis Syndrome in Children from West Pomerania Region
title_full_unstemmed	Chronic Milk-Dependent Food Protein-Induced Enterocolitis Syndrome in Children from West Pomerania Region
title_sort	chronic milk-dependent food protein-induced enterocolitis syndrome in children from west pomerania region
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/067e21d101b94b498b181addace3d8cd
work_keys_str_mv	AT karolinabulsa chronicmilkdependentfoodproteininducedenterocolitissyndromeinchildrenfromwestpomeraniaregion AT małgorzatastandowicz chronicmilkdependentfoodproteininducedenterocolitissyndromeinchildrenfromwestpomeraniaregion AT elzbietabaryłapankiewicz chronicmilkdependentfoodproteininducedenterocolitissyndromeinchildrenfromwestpomeraniaregion AT grazynaczajabulsa chronicmilkdependentfoodproteininducedenterocolitissyndromeinchildrenfromwestpomeraniaregion
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Chronic Milk-Dependent Food Protein-Induced Enterocolitis Syndrome in Children from West Pomerania Region

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