Low birth weight as a potential risk factor for severe COVID-19 in adults

Abstract The identification of factors predisposing to severe COVID-19 in young adults remains partially characterized. Low birth weight (LBW) alters cardiovascular and lung development and predisposes to adult disease. We hypothesized that LBW is a risk factor for severe COVID-19 in non-elderly sub...

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Autores principales:	Fàtima Crispi, Francesca Crovetto, Marta Larroya, Marta Camacho, Marta Tortajada, Oriol Sibila, Joan Ramon Badia, Marta López, Kilian Vellvé, Ferran Garcia, Antoni Trilla, Rosa Faner, Isabel Blanco, Roger Borràs, Alvar Agustí, Eduard Gratacós
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/067e96259b4248e58ea04143063694f6
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spelling	oai:doaj.org-article:067e96259b4248e58ea04143063694f62021-12-02T10:44:21ZLow birth weight as a potential risk factor for severe COVID-19 in adults10.1038/s41598-021-82389-92045-2322https://doaj.org/article/067e96259b4248e58ea04143063694f62021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82389-9https://doaj.org/toc/2045-2322Abstract The identification of factors predisposing to severe COVID-19 in young adults remains partially characterized. Low birth weight (LBW) alters cardiovascular and lung development and predisposes to adult disease. We hypothesized that LBW is a risk factor for severe COVID-19 in non-elderly subjects. We analyzed a prospective cohort of 397 patients (18–70 years) with laboratory-confirmed SARS-CoV-2 infection attended in a tertiary hospital, where 15% required admission to Intensive Care Unit (ICU). Perinatal and current potentially predictive variables were obtained from all patients and LBW was defined as birth weight ≤ 2.500 g. Age (adjusted OR (aOR) 1.04 [1–1.07], P = 0.012), male sex (aOR 3.39 [1.72–6.67], P < 0.001), hypertension (aOR 3.37 [1.69–6.72], P = 0.001), and LBW (aOR 3.61 [1.55–8.43], P = 0.003) independently predicted admission to ICU. The area under the receiver-operating characteristics curve (AUC) of this model was 0.79 [95% CI, 0.74–0.85], with positive and negative predictive values of 29.1% and 97.6% respectively. Results were reproduced in an independent cohort, from a web-based survey in 1822 subjects who self-reported laboratory-positive SARS-CoV-2 infection, where 46 patients (2.5%) needed ICU admission (AUC 0.74 [95% CI 0.68–0.81]). LBW seems to be an independent risk factor for severe COVID-19 in non-elderly adults and might improve the performance of risk stratification algorithms.Fàtima CrispiFrancesca CrovettoMarta LarroyaMarta CamachoMarta TortajadaOriol SibilaJoan Ramon BadiaMarta LópezKilian VellvéFerran GarciaAntoni TrillaRosa FanerIsabel BlancoRoger BorràsAlvar AgustíEduard GratacósNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Fàtima Crispi Francesca Crovetto Marta Larroya Marta Camacho Marta Tortajada Oriol Sibila Joan Ramon Badia Marta López Kilian Vellvé Ferran Garcia Antoni Trilla Rosa Faner Isabel Blanco Roger Borràs Alvar Agustí Eduard Gratacós Low birth weight as a potential risk factor for severe COVID-19 in adults
description	Abstract The identification of factors predisposing to severe COVID-19 in young adults remains partially characterized. Low birth weight (LBW) alters cardiovascular and lung development and predisposes to adult disease. We hypothesized that LBW is a risk factor for severe COVID-19 in non-elderly subjects. We analyzed a prospective cohort of 397 patients (18–70 years) with laboratory-confirmed SARS-CoV-2 infection attended in a tertiary hospital, where 15% required admission to Intensive Care Unit (ICU). Perinatal and current potentially predictive variables were obtained from all patients and LBW was defined as birth weight ≤ 2.500 g. Age (adjusted OR (aOR) 1.04 [1–1.07], P = 0.012), male sex (aOR 3.39 [1.72–6.67], P < 0.001), hypertension (aOR 3.37 [1.69–6.72], P = 0.001), and LBW (aOR 3.61 [1.55–8.43], P = 0.003) independently predicted admission to ICU. The area under the receiver-operating characteristics curve (AUC) of this model was 0.79 [95% CI, 0.74–0.85], with positive and negative predictive values of 29.1% and 97.6% respectively. Results were reproduced in an independent cohort, from a web-based survey in 1822 subjects who self-reported laboratory-positive SARS-CoV-2 infection, where 46 patients (2.5%) needed ICU admission (AUC 0.74 [95% CI 0.68–0.81]). LBW seems to be an independent risk factor for severe COVID-19 in non-elderly adults and might improve the performance of risk stratification algorithms.
format	article
author	Fàtima Crispi Francesca Crovetto Marta Larroya Marta Camacho Marta Tortajada Oriol Sibila Joan Ramon Badia Marta López Kilian Vellvé Ferran Garcia Antoni Trilla Rosa Faner Isabel Blanco Roger Borràs Alvar Agustí Eduard Gratacós
author_facet	Fàtima Crispi Francesca Crovetto Marta Larroya Marta Camacho Marta Tortajada Oriol Sibila Joan Ramon Badia Marta López Kilian Vellvé Ferran Garcia Antoni Trilla Rosa Faner Isabel Blanco Roger Borràs Alvar Agustí Eduard Gratacós
author_sort	Fàtima Crispi
title	Low birth weight as a potential risk factor for severe COVID-19 in adults
title_short	Low birth weight as a potential risk factor for severe COVID-19 in adults
title_full	Low birth weight as a potential risk factor for severe COVID-19 in adults
title_fullStr	Low birth weight as a potential risk factor for severe COVID-19 in adults
title_full_unstemmed	Low birth weight as a potential risk factor for severe COVID-19 in adults
title_sort	low birth weight as a potential risk factor for severe covid-19 in adults
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/067e96259b4248e58ea04143063694f6
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Low birth weight as a potential risk factor for severe COVID-19 in adults

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