Genetic dissection of the miR-200–Zeb1 axis reveals its importance in tumor differentiation and invasion

In vivo studies on the regulation of the epithelial-mesenchymal transition (EMT) within a physiological context are lacking. Here it is shown that miR-200 ablation in the Rip-Tag2 insulinoma mouse model induces beta-cell dedifferentiation, EMT and tumor invasion, and that disruption of Zeb1 regulati...

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Autores principales:	Alexandra C. Title, Sue-Jean Hong, Nuno D. Pires, Lynn Hasenöhrl, Svenja Godbersen, Nadine Stokar-Regenscheit, David P. Bartel, Markus Stoffel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/068557ba50e34310a2f544f7ab2c5930
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spelling	oai:doaj.org-article:068557ba50e34310a2f544f7ab2c59302021-12-02T16:56:40ZGenetic dissection of the miR-200–Zeb1 axis reveals its importance in tumor differentiation and invasion10.1038/s41467-018-07130-z2041-1723https://doaj.org/article/068557ba50e34310a2f544f7ab2c59302018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07130-zhttps://doaj.org/toc/2041-1723In vivo studies on the regulation of the epithelial-mesenchymal transition (EMT) within a physiological context are lacking. Here it is shown that miR-200 ablation in the Rip-Tag2 insulinoma mouse model induces beta-cell dedifferentiation, EMT and tumor invasion, and that disruption of Zeb1 regulation by miR-200c is sufficient to drive EMT.Alexandra C. TitleSue-Jean HongNuno D. PiresLynn HasenöhrlSvenja GodbersenNadine Stokar-RegenscheitDavid P. BartelMarkus StoffelNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Alexandra C. Title Sue-Jean Hong Nuno D. Pires Lynn Hasenöhrl Svenja Godbersen Nadine Stokar-Regenscheit David P. Bartel Markus Stoffel Genetic dissection of the miR-200–Zeb1 axis reveals its importance in tumor differentiation and invasion
description	In vivo studies on the regulation of the epithelial-mesenchymal transition (EMT) within a physiological context are lacking. Here it is shown that miR-200 ablation in the Rip-Tag2 insulinoma mouse model induces beta-cell dedifferentiation, EMT and tumor invasion, and that disruption of Zeb1 regulation by miR-200c is sufficient to drive EMT.
format	article
author	Alexandra C. Title Sue-Jean Hong Nuno D. Pires Lynn Hasenöhrl Svenja Godbersen Nadine Stokar-Regenscheit David P. Bartel Markus Stoffel
author_facet	Alexandra C. Title Sue-Jean Hong Nuno D. Pires Lynn Hasenöhrl Svenja Godbersen Nadine Stokar-Regenscheit David P. Bartel Markus Stoffel
author_sort	Alexandra C. Title
title	Genetic dissection of the miR-200–Zeb1 axis reveals its importance in tumor differentiation and invasion
title_short	Genetic dissection of the miR-200–Zeb1 axis reveals its importance in tumor differentiation and invasion
title_full	Genetic dissection of the miR-200–Zeb1 axis reveals its importance in tumor differentiation and invasion
title_fullStr	Genetic dissection of the miR-200–Zeb1 axis reveals its importance in tumor differentiation and invasion
title_full_unstemmed	Genetic dissection of the miR-200–Zeb1 axis reveals its importance in tumor differentiation and invasion
title_sort	genetic dissection of the mir-200–zeb1 axis reveals its importance in tumor differentiation and invasion
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/068557ba50e34310a2f544f7ab2c5930
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Genetic dissection of the miR-200–Zeb1 axis reveals its importance in tumor differentiation and invasion

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