Genetic dissection of the miR-200–Zeb1 axis reveals its importance in tumor differentiation and invasion

Genetic dissection of the miR-200–Zeb1 axis reveals its importance in tumor differentiation and invasion

In vivo studies on the regulation of the epithelial-mesenchymal transition (EMT) within a physiological context are lacking. Here it is shown that miR-200 ablation in the Rip-Tag2 insulinoma mouse model induces beta-cell dedifferentiation, EMT and tumor invasion, and that disruption of Zeb1 regulati...

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Autores principales: Alexandra C. Title, Sue-Jean Hong, Nuno D. Pires, Lynn Hasenöhrl, Svenja Godbersen, Nadine Stokar-Regenscheit, David P. Bartel, Markus Stoffel
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Science
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Acceso en línea:https://doaj.org/article/068557ba50e34310a2f544f7ab2c5930
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