Inhibin B in diagnosis and monitoring of granulosa-cell tumors of ovary

Introduction. Granulosa cell tumors of ovary (GCTO) rare type of malignant ovarian neoplasms formed from granulosa cells of the follicles capable to produce biologically active substances, including inhibin B. The purpose of this study is evaluation of clinical significance of inhibin B analysis in...

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Autores principales:	Nina V. Lyubimova, Almaz M. Beishembaev, Yurii S. Timofeev, Kirill I. Zhordania, Nikolai E. Kushlinskii
Formato:	article
Lenguaje:	RU
Publicado:	IP Habib O.N. 2020
Materias:	granulosa-cell tumors of ovary inhibin b diagnosis biochemical marker Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/06874091438a4aa1aa57cb0ab7145aa7
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spelling	oai:doaj.org-article:06874091438a4aa1aa57cb0ab7145aa72021-11-30T17:03:34ZInhibin B in diagnosis and monitoring of granulosa-cell tumors of ovary1815-14341815-144210.26442/18151434.2020.2.200121https://doaj.org/article/06874091438a4aa1aa57cb0ab7145aa72020-07-01T00:00:00Zhttps://modernonco.orscience.ru/1815-1434/article/viewFile/34965/23381https://doaj.org/toc/1815-1434https://doaj.org/toc/1815-1442Introduction. Granulosa cell tumors of ovary (GCTO) rare type of malignant ovarian neoplasms formed from granulosa cells of the follicles capable to produce biologically active substances, including inhibin B. The purpose of this study is evaluation of clinical significance of inhibin B analysis in blood serum of patients with adult type of GCTO primary disease, relapse and during remission after treatment. Materials and methods. The study included 134 patients with GCTO, 15 patients with benign ovarian tumors and 82 healthy women. Inhibin B was determined in blood serum with standard enzyme-linked immunosorbent assay Inhibin B Gen II ELISA (Beckman Coulter, USA) in the microplate format. Results. The analysis data indicates a high sensitivity of inhibin B in the diagnosis of primary GCTO (92.3%) and in relapse (92.7%) with a specificity 100%. An increase of inhibin B before the clinical manifestation of relapse (for 212 months) confirms its significance as an effective biochemical marker for GCTO monitoring. Conclusion. Inhibin B can be used as effective biochemical marker of primary and GCTO and its relapses.Nina V. LyubimovaAlmaz M. BeishembaevYurii S. TimofeevKirill I. ZhordaniaNikolai E. KushlinskiiIP Habib O.N.articlegranulosa-cell tumors of ovaryinhibin bdiagnosisbiochemical markerNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282RUСовременная онкология, Vol 22, Iss 2, Pp 116-118 (2020)
institution	DOAJ
collection	DOAJ
language	RU
topic	granulosa-cell tumors of ovary inhibin b diagnosis biochemical marker Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	granulosa-cell tumors of ovary inhibin b diagnosis biochemical marker Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Nina V. Lyubimova Almaz M. Beishembaev Yurii S. Timofeev Kirill I. Zhordania Nikolai E. Kushlinskii Inhibin B in diagnosis and monitoring of granulosa-cell tumors of ovary
description	Introduction. Granulosa cell tumors of ovary (GCTO) rare type of malignant ovarian neoplasms formed from granulosa cells of the follicles capable to produce biologically active substances, including inhibin B. The purpose of this study is evaluation of clinical significance of inhibin B analysis in blood serum of patients with adult type of GCTO primary disease, relapse and during remission after treatment. Materials and methods. The study included 134 patients with GCTO, 15 patients with benign ovarian tumors and 82 healthy women. Inhibin B was determined in blood serum with standard enzyme-linked immunosorbent assay Inhibin B Gen II ELISA (Beckman Coulter, USA) in the microplate format. Results. The analysis data indicates a high sensitivity of inhibin B in the diagnosis of primary GCTO (92.3%) and in relapse (92.7%) with a specificity 100%. An increase of inhibin B before the clinical manifestation of relapse (for 212 months) confirms its significance as an effective biochemical marker for GCTO monitoring. Conclusion. Inhibin B can be used as effective biochemical marker of primary and GCTO and its relapses.
format	article
author	Nina V. Lyubimova Almaz M. Beishembaev Yurii S. Timofeev Kirill I. Zhordania Nikolai E. Kushlinskii
author_facet	Nina V. Lyubimova Almaz M. Beishembaev Yurii S. Timofeev Kirill I. Zhordania Nikolai E. Kushlinskii
author_sort	Nina V. Lyubimova
title	Inhibin B in diagnosis and monitoring of granulosa-cell tumors of ovary
title_short	Inhibin B in diagnosis and monitoring of granulosa-cell tumors of ovary
title_full	Inhibin B in diagnosis and monitoring of granulosa-cell tumors of ovary
title_fullStr	Inhibin B in diagnosis and monitoring of granulosa-cell tumors of ovary
title_full_unstemmed	Inhibin B in diagnosis and monitoring of granulosa-cell tumors of ovary
title_sort	inhibin b in diagnosis and monitoring of granulosa-cell tumors of ovary
publisher	IP Habib O.N.
publishDate	2020
url	https://doaj.org/article/06874091438a4aa1aa57cb0ab7145aa7
work_keys_str_mv	AT ninavlyubimova inhibinbindiagnosisandmonitoringofgranulosacelltumorsofovary AT almazmbeishembaev inhibinbindiagnosisandmonitoringofgranulosacelltumorsofovary AT yuriistimofeev inhibinbindiagnosisandmonitoringofgranulosacelltumorsofovary AT kirillizhordania inhibinbindiagnosisandmonitoringofgranulosacelltumorsofovary AT nikolaiekushlinskii inhibinbindiagnosisandmonitoringofgranulosacelltumorsofovary
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Inhibin B in diagnosis and monitoring of granulosa-cell tumors of ovary

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