Pancreatic ductal adenocarcinoma immune microenvironment and immunotherapy prospects

The tumor microenvironment of pancreatic ductal adenocarcinoma (PDAC) is non-immunogenic, which consists of the stellate cells, fibroblasts, immune cells, extracellular matrix, and some other immune suppressive molecules. This low tumor perfusion microenvironment with physical dense fibrotic stroma...

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Autores principales:	Ke-Yu Li, Jia-Long Yuan, Diego Trafton, Jian-Xin Wang, Nan Niu, Chun-Hui Yuan, Xu-Bao Liu, Lei Zheng
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2020
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/068e0b659ab5479994664ec39f0590ca
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spelling	oai:doaj.org-article:068e0b659ab5479994664ec39f0590ca2021-12-02T16:02:14ZPancreatic ductal adenocarcinoma immune microenvironment and immunotherapy prospects2095-882X10.1016/j.cdtm.2020.01.002https://doaj.org/article/068e0b659ab5479994664ec39f0590ca2020-03-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2095882X20300025https://doaj.org/toc/2095-882XThe tumor microenvironment of pancreatic ductal adenocarcinoma (PDAC) is non-immunogenic, which consists of the stellate cells, fibroblasts, immune cells, extracellular matrix, and some other immune suppressive molecules. This low tumor perfusion microenvironment with physical dense fibrotic stroma shields PDAC from traditional antitumor therapies like chemotherapy and various strategies that have been proven successful in other types of cancer. Immunotherapy has the potential to treat minimal and residual diseases and prevent recurrence with minimal toxicity, and studies in patients with metastatic and nonresectable disease have shown some efficacy. In this review, we highlighted the main components of the pancreatic tumor microenvironment, and meanwhile, summarized the advances of some promising immunotherapies for PDAC, including checkpoint inhibitors, chimeric antigen receptors T cells, and cancer vaccines. Based on our previous researches, we specifically discussed how granulocyte-macrophage colony stimulating factor based pancreatic cancer vaccine prime the pancreatic tumor microenvironment, and introduced some novel immunoadjuvants, like the stimulator of interferon genes. Keywords: Pancreatic ductal adenocarcinoma, Tumor microenvironment, Immunotherapy, Cancer vaccine, Stimulator of interferon genesKe-Yu LiJia-Long YuanDiego TraftonJian-Xin WangNan NiuChun-Hui YuanXu-Bao LiuLei ZhengKeAi Communications Co., Ltd.articleMedicine (General)R5-920ENChronic Diseases and Translational Medicine, Vol 6, Iss 1, Pp 6-17 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Ke-Yu Li Jia-Long Yuan Diego Trafton Jian-Xin Wang Nan Niu Chun-Hui Yuan Xu-Bao Liu Lei Zheng Pancreatic ductal adenocarcinoma immune microenvironment and immunotherapy prospects
description	The tumor microenvironment of pancreatic ductal adenocarcinoma (PDAC) is non-immunogenic, which consists of the stellate cells, fibroblasts, immune cells, extracellular matrix, and some other immune suppressive molecules. This low tumor perfusion microenvironment with physical dense fibrotic stroma shields PDAC from traditional antitumor therapies like chemotherapy and various strategies that have been proven successful in other types of cancer. Immunotherapy has the potential to treat minimal and residual diseases and prevent recurrence with minimal toxicity, and studies in patients with metastatic and nonresectable disease have shown some efficacy. In this review, we highlighted the main components of the pancreatic tumor microenvironment, and meanwhile, summarized the advances of some promising immunotherapies for PDAC, including checkpoint inhibitors, chimeric antigen receptors T cells, and cancer vaccines. Based on our previous researches, we specifically discussed how granulocyte-macrophage colony stimulating factor based pancreatic cancer vaccine prime the pancreatic tumor microenvironment, and introduced some novel immunoadjuvants, like the stimulator of interferon genes. Keywords: Pancreatic ductal adenocarcinoma, Tumor microenvironment, Immunotherapy, Cancer vaccine, Stimulator of interferon genes
format	article
author	Ke-Yu Li Jia-Long Yuan Diego Trafton Jian-Xin Wang Nan Niu Chun-Hui Yuan Xu-Bao Liu Lei Zheng
author_facet	Ke-Yu Li Jia-Long Yuan Diego Trafton Jian-Xin Wang Nan Niu Chun-Hui Yuan Xu-Bao Liu Lei Zheng
author_sort	Ke-Yu Li
title	Pancreatic ductal adenocarcinoma immune microenvironment and immunotherapy prospects
title_short	Pancreatic ductal adenocarcinoma immune microenvironment and immunotherapy prospects
title_full	Pancreatic ductal adenocarcinoma immune microenvironment and immunotherapy prospects
title_fullStr	Pancreatic ductal adenocarcinoma immune microenvironment and immunotherapy prospects
title_full_unstemmed	Pancreatic ductal adenocarcinoma immune microenvironment and immunotherapy prospects
title_sort	pancreatic ductal adenocarcinoma immune microenvironment and immunotherapy prospects
publisher	KeAi Communications Co., Ltd.
publishDate	2020
url	https://doaj.org/article/068e0b659ab5479994664ec39f0590ca
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_version_	1718385250490384384

Pancreatic ductal adenocarcinoma immune microenvironment and immunotherapy prospects

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