Cyclooxygenase-2 as a biomarker with diagnostic, therapeutic, prognostic, and predictive relevance in small animal oncology

In canine and feline populations, the number of neoplasm cases continues to increase around the world. Attempts are being made in centres of research to identify new biomarkers that speed up and improve the quality of oncological diagnostics and therapy in human and animal tumour patients. Cyclooxyg...

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Autores principales:	Szweda Marta, Rychlik Andrzej, Babińska Izabella, Pomianowski Andrzej
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2020
Materias:	dog cat biomarker cox-2 tumours Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/069126e8849f4e33936e7a6381c31749
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id	oai:doaj.org-article:069126e8849f4e33936e7a6381c31749
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spelling	oai:doaj.org-article:069126e8849f4e33936e7a6381c317492021-12-05T14:11:08ZCyclooxygenase-2 as a biomarker with diagnostic, therapeutic, prognostic, and predictive relevance in small animal oncology2450-860810.2478/jvetres-2020-0018https://doaj.org/article/069126e8849f4e33936e7a6381c317492020-03-01T00:00:00Zhttps://doi.org/10.2478/jvetres-2020-0018https://doaj.org/toc/2450-8608In canine and feline populations, the number of neoplasm cases continues to increase around the world. Attempts are being made in centres of research to identify new biomarkers that speed up and improve the quality of oncological diagnostics and therapy in human and animal tumour patients. Cyclooxygenase-2 (COX-2) is a promising biomarker with increasing relevance to human oncology, but as yet with less application in veterinary oncology. The expression of COX-2 increases significantly during pathological processes involving inflammation, pain or fever. It is also overexpressed in humans presenting various types of tumours and in selected types of tumours in animals, particularly in dogs. This article discusses the expression of COX-2 in canine and feline tumours, the importance of COX-2 as a biomarker with diagnostic, therapeutic, prognostic and predictive relevance in oncology, and the clinical significance of inhibiting COX-2 overexpression in tumours.Szweda MartaRychlik AndrzejBabińska IzabellaPomianowski AndrzejSciendoarticledogcatbiomarkercox-2tumoursVeterinary medicineSF600-1100ENJournal of Veterinary Research, Vol 64, Iss 1, Pp 151-160 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	dog cat biomarker cox-2 tumours Veterinary medicine SF600-1100
spellingShingle	dog cat biomarker cox-2 tumours Veterinary medicine SF600-1100 Szweda Marta Rychlik Andrzej Babińska Izabella Pomianowski Andrzej Cyclooxygenase-2 as a biomarker with diagnostic, therapeutic, prognostic, and predictive relevance in small animal oncology
description	In canine and feline populations, the number of neoplasm cases continues to increase around the world. Attempts are being made in centres of research to identify new biomarkers that speed up and improve the quality of oncological diagnostics and therapy in human and animal tumour patients. Cyclooxygenase-2 (COX-2) is a promising biomarker with increasing relevance to human oncology, but as yet with less application in veterinary oncology. The expression of COX-2 increases significantly during pathological processes involving inflammation, pain or fever. It is also overexpressed in humans presenting various types of tumours and in selected types of tumours in animals, particularly in dogs. This article discusses the expression of COX-2 in canine and feline tumours, the importance of COX-2 as a biomarker with diagnostic, therapeutic, prognostic and predictive relevance in oncology, and the clinical significance of inhibiting COX-2 overexpression in tumours.
format	article
author	Szweda Marta Rychlik Andrzej Babińska Izabella Pomianowski Andrzej
author_facet	Szweda Marta Rychlik Andrzej Babińska Izabella Pomianowski Andrzej
author_sort	Szweda Marta
title	Cyclooxygenase-2 as a biomarker with diagnostic, therapeutic, prognostic, and predictive relevance in small animal oncology
title_short	Cyclooxygenase-2 as a biomarker with diagnostic, therapeutic, prognostic, and predictive relevance in small animal oncology
title_full	Cyclooxygenase-2 as a biomarker with diagnostic, therapeutic, prognostic, and predictive relevance in small animal oncology
title_fullStr	Cyclooxygenase-2 as a biomarker with diagnostic, therapeutic, prognostic, and predictive relevance in small animal oncology
title_full_unstemmed	Cyclooxygenase-2 as a biomarker with diagnostic, therapeutic, prognostic, and predictive relevance in small animal oncology
title_sort	cyclooxygenase-2 as a biomarker with diagnostic, therapeutic, prognostic, and predictive relevance in small animal oncology
publisher	Sciendo
publishDate	2020
url	https://doaj.org/article/069126e8849f4e33936e7a6381c31749
work_keys_str_mv	AT szwedamarta cyclooxygenase2asabiomarkerwithdiagnostictherapeuticprognosticandpredictiverelevanceinsmallanimaloncology AT rychlikandrzej cyclooxygenase2asabiomarkerwithdiagnostictherapeuticprognosticandpredictiverelevanceinsmallanimaloncology AT babinskaizabella cyclooxygenase2asabiomarkerwithdiagnostictherapeuticprognosticandpredictiverelevanceinsmallanimaloncology AT pomianowskiandrzej cyclooxygenase2asabiomarkerwithdiagnostictherapeuticprognosticandpredictiverelevanceinsmallanimaloncology
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Cyclooxygenase-2 as a biomarker with diagnostic, therapeutic, prognostic, and predictive relevance in small animal oncology

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