TLR2 ligands induce NF-κB activation from endosomal compartments of human monocytes.

Localization of Toll-like receptors (TLR) in subcellular organelles is a major strategy to regulate innate immune responses. While TLR4, a cell-surface receptor, signals from both the plasma membrane and endosomal compartments, less is known about the functional role of endosomal trafficking upon TL...

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Autores principales: Karim J Brandt, Céline Fickentscher, Egbert K O Kruithof, Philippe de Moerloose
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
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Acceso en línea:https://doaj.org/article/069241185f374cc58c2e12173649df8a
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