DNA replication licensing factor Cdc6 and Plk4 kinase antagonistically regulate centrosome duplication via Sas-6

Centrosome duplication is synchronized with cell cycle events but how this is regulated at a molecular level is unclear. Here, the authors show that the DNA replication licensing factor Cdc6 restrains centrosome duplication via binding and inhibiting Sas-6, and the inhibition of Cdc6 on Sas-6 is neg...

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Autores principales:	Xiaowei Xu, Shijiao Huang, Boyan Zhang, Fan Huang, Wangfei Chi, Jingyan Fu, Gang Wang, Si Li, Qing Jiang, Chuanmao Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0692766c11f74048be000b1ec56e2757
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spelling	oai:doaj.org-article:0692766c11f74048be000b1ec56e27572021-12-02T14:40:48ZDNA replication licensing factor Cdc6 and Plk4 kinase antagonistically regulate centrosome duplication via Sas-610.1038/ncomms151642041-1723https://doaj.org/article/0692766c11f74048be000b1ec56e27572017-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms15164https://doaj.org/toc/2041-1723Centrosome duplication is synchronized with cell cycle events but how this is regulated at a molecular level is unclear. Here, the authors show that the DNA replication licensing factor Cdc6 restrains centrosome duplication via binding and inhibiting Sas-6, and the inhibition of Cdc6 on Sas-6 is negatively regulated by Plk4 phosphorylation.Xiaowei XuShijiao HuangBoyan ZhangFan HuangWangfei ChiJingyan FuGang WangSi LiQing JiangChuanmao ZhangNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xiaowei Xu Shijiao Huang Boyan Zhang Fan Huang Wangfei Chi Jingyan Fu Gang Wang Si Li Qing Jiang Chuanmao Zhang DNA replication licensing factor Cdc6 and Plk4 kinase antagonistically regulate centrosome duplication via Sas-6
description	Centrosome duplication is synchronized with cell cycle events but how this is regulated at a molecular level is unclear. Here, the authors show that the DNA replication licensing factor Cdc6 restrains centrosome duplication via binding and inhibiting Sas-6, and the inhibition of Cdc6 on Sas-6 is negatively regulated by Plk4 phosphorylation.
format	article
author	Xiaowei Xu Shijiao Huang Boyan Zhang Fan Huang Wangfei Chi Jingyan Fu Gang Wang Si Li Qing Jiang Chuanmao Zhang
author_facet	Xiaowei Xu Shijiao Huang Boyan Zhang Fan Huang Wangfei Chi Jingyan Fu Gang Wang Si Li Qing Jiang Chuanmao Zhang
author_sort	Xiaowei Xu
title	DNA replication licensing factor Cdc6 and Plk4 kinase antagonistically regulate centrosome duplication via Sas-6
title_short	DNA replication licensing factor Cdc6 and Plk4 kinase antagonistically regulate centrosome duplication via Sas-6
title_full	DNA replication licensing factor Cdc6 and Plk4 kinase antagonistically regulate centrosome duplication via Sas-6
title_fullStr	DNA replication licensing factor Cdc6 and Plk4 kinase antagonistically regulate centrosome duplication via Sas-6
title_full_unstemmed	DNA replication licensing factor Cdc6 and Plk4 kinase antagonistically regulate centrosome duplication via Sas-6
title_sort	dna replication licensing factor cdc6 and plk4 kinase antagonistically regulate centrosome duplication via sas-6
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/0692766c11f74048be000b1ec56e2757
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DNA replication licensing factor Cdc6 and Plk4 kinase antagonistically regulate centrosome duplication via Sas-6

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