Nanozymes as Enzyme Inhibitors

Yaling Huang,1 Jian Jiang,1 Yanqiu Wang,1 Jie Chen,1 Juqun Xi1,2 1Institute of Translational Medicine, Department of Pharmacology, School of Medicine, Yangzhou University, Yangzhou, Jiangsu, 225001, People’s Republic of China; 2Jiangsu Key Laboratory of Integrated Traditional Chinese and W...

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Autores principales:	Huang Y, Jiang J, Wang Y, Chen J, Xi J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	nanozyme r-chymotrypsin inhibitor β-galactosidase inhibitor β-lactamase inhibitor mitochondrial f0f1-atpase inhibitor Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/0695065aa0494aed9f067a8d3aeed4d6
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spelling	oai:doaj.org-article:0695065aa0494aed9f067a8d3aeed4d62021-12-02T13:50:53ZNanozymes as Enzyme Inhibitors1178-2013https://doaj.org/article/0695065aa0494aed9f067a8d3aeed4d62021-02-01T00:00:00Zhttps://www.dovepress.com/nanozymes-as-enzyme-inhibitors-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Yaling Huang,1 Jian Jiang,1 Yanqiu Wang,1 Jie Chen,1 Juqun Xi1,2 1Institute of Translational Medicine, Department of Pharmacology, School of Medicine, Yangzhou University, Yangzhou, Jiangsu, 225001, People’s Republic of China; 2Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases, Yangzhou, Jiangsu, 225001, People’s Republic of ChinaCorrespondence: Juqun XiInstitute of Translational Medicine, Department of Pharmacology, School of Medicine, Yangzhou University, Yangzhou, Jiangsu, 225001, People’s Republic of ChinaTel +86 0514-87978804Fax +86 0514-87341733Email xijq@yzu.edu.cnAbstract: Nanozyme is a type of nanomaterial with intrinsic enzyme-like activity. Following the discovery of nanozymes in 2007, nanozyme technology has become an emerging field bridging nanotechnology and biology, attracting research from multi-disciplinary areas focused on the design and synthesis of catalytically active nanozymes. However, various types of enzymes can be mimicked by nanomaterials, and our current understanding of nanozymes as enzyme inhibitors is limited. Here, we provide a brief overview of the utility of nanozymes as inhibitors of enzymes, such as R-chymotrypsin (ChT), β-galactosidase (β-Gal), β-lactamase, and mitochondrial F0F1-ATPase, and the mechanisms underlying inhibitory activity. The advantages, challenges and future research directions of nanozymes as enzyme inhibitors for biomedical research are further discussed.Keywords: nanozyme, R-chymotrypsin inhibitor, β-galactosidase inhibitor, β-lactamase inhibitor, mitochondrial F0F1-ATPase inhibitorHuang YJiang JWang YChen JXi JDove Medical Pressarticlenanozymer-chymotrypsin inhibitorβ-galactosidase inhibitorβ-lactamase inhibitormitochondrial f0f1-atpase inhibitorMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 16, Pp 1143-1155 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	nanozyme r-chymotrypsin inhibitor β-galactosidase inhibitor β-lactamase inhibitor mitochondrial f0f1-atpase inhibitor Medicine (General) R5-920
spellingShingle	nanozyme r-chymotrypsin inhibitor β-galactosidase inhibitor β-lactamase inhibitor mitochondrial f0f1-atpase inhibitor Medicine (General) R5-920 Huang Y Jiang J Wang Y Chen J Xi J Nanozymes as Enzyme Inhibitors
description	Yaling Huang,1 Jian Jiang,1 Yanqiu Wang,1 Jie Chen,1 Juqun Xi1,2 1Institute of Translational Medicine, Department of Pharmacology, School of Medicine, Yangzhou University, Yangzhou, Jiangsu, 225001, People’s Republic of China; 2Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases, Yangzhou, Jiangsu, 225001, People’s Republic of ChinaCorrespondence: Juqun XiInstitute of Translational Medicine, Department of Pharmacology, School of Medicine, Yangzhou University, Yangzhou, Jiangsu, 225001, People’s Republic of ChinaTel +86 0514-87978804Fax +86 0514-87341733Email xijq@yzu.edu.cnAbstract: Nanozyme is a type of nanomaterial with intrinsic enzyme-like activity. Following the discovery of nanozymes in 2007, nanozyme technology has become an emerging field bridging nanotechnology and biology, attracting research from multi-disciplinary areas focused on the design and synthesis of catalytically active nanozymes. However, various types of enzymes can be mimicked by nanomaterials, and our current understanding of nanozymes as enzyme inhibitors is limited. Here, we provide a brief overview of the utility of nanozymes as inhibitors of enzymes, such as R-chymotrypsin (ChT), β-galactosidase (β-Gal), β-lactamase, and mitochondrial F0F1-ATPase, and the mechanisms underlying inhibitory activity. The advantages, challenges and future research directions of nanozymes as enzyme inhibitors for biomedical research are further discussed.Keywords: nanozyme, R-chymotrypsin inhibitor, β-galactosidase inhibitor, β-lactamase inhibitor, mitochondrial F0F1-ATPase inhibitor
format	article
author	Huang Y Jiang J Wang Y Chen J Xi J
author_facet	Huang Y Jiang J Wang Y Chen J Xi J
author_sort	Huang Y
title	Nanozymes as Enzyme Inhibitors
title_short	Nanozymes as Enzyme Inhibitors
title_full	Nanozymes as Enzyme Inhibitors
title_fullStr	Nanozymes as Enzyme Inhibitors
title_full_unstemmed	Nanozymes as Enzyme Inhibitors
title_sort	nanozymes as enzyme inhibitors
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/0695065aa0494aed9f067a8d3aeed4d6
work_keys_str_mv	AT huangy nanozymesasenzymeinhibitors AT jiangj nanozymesasenzymeinhibitors AT wangy nanozymesasenzymeinhibitors AT chenj nanozymesasenzymeinhibitors AT xij nanozymesasenzymeinhibitors
_version_	1718392418584231936

Nanozymes as Enzyme Inhibitors

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