Needle-free delivery of measles virus vaccine to the lower respiratory tract of non-human primates elicits optimal immunity and protection

Measles: The efficacy of needle-free vaccine delivery Research shows that measles aerosol vaccination is effective when the vaccine is delivered to the lower respiratory tract. Measles virus is a highly contagious and potentially deadly human pathogen, but is easily prevented by vaccination. An inte...

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Autores principales:	Rik L. de Swart, Rory D. de Vries, Linda J. Rennick, Geert van Amerongen, Stephen McQuaid, R. Joyce Verburgh, Selma Yüksel, Alwin de Jong, Ken Lemon, D. Tien Nguyen, Martin Ludlow, Albert D. M. E. Osterhaus, W. Paul Duprex
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/0697d6a8f6fd4e159492aab5b1682ba5
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spelling	oai:doaj.org-article:0697d6a8f6fd4e159492aab5b1682ba52021-12-02T16:19:59ZNeedle-free delivery of measles virus vaccine to the lower respiratory tract of non-human primates elicits optimal immunity and protection10.1038/s41541-017-0022-82059-0105https://doaj.org/article/0697d6a8f6fd4e159492aab5b1682ba52017-08-01T00:00:00Zhttps://doi.org/10.1038/s41541-017-0022-8https://doaj.org/toc/2059-0105Measles: The efficacy of needle-free vaccine delivery Research shows that measles aerosol vaccination is effective when the vaccine is delivered to the lower respiratory tract. Measles virus is a highly contagious and potentially deadly human pathogen, but is easily prevented by vaccination. An international team led by Paul Duprex, of the United States’ Boston University School of Medicine, and Rik de Swart, of the Erasmus University Medical Center, The Netherlands, investigated the effectiveness of different routes of measles vaccine administration in non-human primates. They found that macaques responded well to aerosolized administration of the live-attenuated measles vaccine and they were effectively protected from subsequent measles virus infection. Vaccine delivery to the lower respiratory tract was most effective in eliciting protective immune responses. This research is a step towards easier vaccination protocols and away from dependency on sterile needles and trained health-care workers — an important consideration in the developing world.Rik L. de SwartRory D. de VriesLinda J. RennickGeert van AmerongenStephen McQuaidR. Joyce VerburghSelma YükselAlwin de JongKen LemonD. Tien NguyenMartin LudlowAlbert D. M. E. OsterhausW. Paul DuprexNature PortfolioarticleImmunologic diseases. AllergyRC581-607Neoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENnpj Vaccines, Vol 2, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Rik L. de Swart Rory D. de Vries Linda J. Rennick Geert van Amerongen Stephen McQuaid R. Joyce Verburgh Selma Yüksel Alwin de Jong Ken Lemon D. Tien Nguyen Martin Ludlow Albert D. M. E. Osterhaus W. Paul Duprex Needle-free delivery of measles virus vaccine to the lower respiratory tract of non-human primates elicits optimal immunity and protection
description	Measles: The efficacy of needle-free vaccine delivery Research shows that measles aerosol vaccination is effective when the vaccine is delivered to the lower respiratory tract. Measles virus is a highly contagious and potentially deadly human pathogen, but is easily prevented by vaccination. An international team led by Paul Duprex, of the United States’ Boston University School of Medicine, and Rik de Swart, of the Erasmus University Medical Center, The Netherlands, investigated the effectiveness of different routes of measles vaccine administration in non-human primates. They found that macaques responded well to aerosolized administration of the live-attenuated measles vaccine and they were effectively protected from subsequent measles virus infection. Vaccine delivery to the lower respiratory tract was most effective in eliciting protective immune responses. This research is a step towards easier vaccination protocols and away from dependency on sterile needles and trained health-care workers — an important consideration in the developing world.
format	article
author	Rik L. de Swart Rory D. de Vries Linda J. Rennick Geert van Amerongen Stephen McQuaid R. Joyce Verburgh Selma Yüksel Alwin de Jong Ken Lemon D. Tien Nguyen Martin Ludlow Albert D. M. E. Osterhaus W. Paul Duprex
author_facet	Rik L. de Swart Rory D. de Vries Linda J. Rennick Geert van Amerongen Stephen McQuaid R. Joyce Verburgh Selma Yüksel Alwin de Jong Ken Lemon D. Tien Nguyen Martin Ludlow Albert D. M. E. Osterhaus W. Paul Duprex
author_sort	Rik L. de Swart
title	Needle-free delivery of measles virus vaccine to the lower respiratory tract of non-human primates elicits optimal immunity and protection
title_short	Needle-free delivery of measles virus vaccine to the lower respiratory tract of non-human primates elicits optimal immunity and protection
title_full	Needle-free delivery of measles virus vaccine to the lower respiratory tract of non-human primates elicits optimal immunity and protection
title_fullStr	Needle-free delivery of measles virus vaccine to the lower respiratory tract of non-human primates elicits optimal immunity and protection
title_full_unstemmed	Needle-free delivery of measles virus vaccine to the lower respiratory tract of non-human primates elicits optimal immunity and protection
title_sort	needle-free delivery of measles virus vaccine to the lower respiratory tract of non-human primates elicits optimal immunity and protection
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/0697d6a8f6fd4e159492aab5b1682ba5
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Needle-free delivery of measles virus vaccine to the lower respiratory tract of non-human primates elicits optimal immunity and protection

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