Sex differences in fear memory consolidation via Tac2 signaling in mice

Sex differences in fear memory consolidation via Tac2 signaling in mice

The Tachykinin 2 (Tac2) pathway in the central amygdala is sufficient and necessary for modulating fear memory consolidation. The authors show that silencing Tac2 neurons in the amygdala of male mice reduces fear expression, while fear expression in female mice is increased when manipulations are ma...

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Autores principales: A. Florido, E. R. Velasco, C. M. Soto-Faguás, A. Gomez-Gomez, L. Perez-Caballero, P. Molina, R. Nadal, O. J. Pozo, C. A. Saura, R. Andero
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Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/069d3bc10a55439ba681f05b81c4f6bc
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spelling oai:doaj.org-article:069d3bc10a55439ba681f05b81c4f6bc2021-12-02T16:51:49ZSex differences in fear memory consolidation via Tac2 signaling in mice10.1038/s41467-021-22911-92041-1723https://doaj.org/article/069d3bc10a55439ba681f05b81c4f6bc2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22911-9https://doaj.org/toc/2041-1723The Tachykinin 2 (Tac2) pathway in the central amygdala is sufficient and necessary for modulating fear memory consolidation. The authors show that silencing Tac2 neurons in the amygdala of male mice reduces fear expression, while fear expression in female mice is increased when manipulations are made during proestrus.A. FloridoE. R. VelascoC. M. Soto-FaguásA. Gomez-GomezL. Perez-CaballeroP. MolinaR. NadalO. J. PozoC. A. SauraR. AnderoNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
A. Florido
E. R. Velasco
C. M. Soto-Faguás
A. Gomez-Gomez
L. Perez-Caballero
P. Molina
R. Nadal
O. J. Pozo
C. A. Saura
R. Andero
Sex differences in fear memory consolidation via Tac2 signaling in mice
description The Tachykinin 2 (Tac2) pathway in the central amygdala is sufficient and necessary for modulating fear memory consolidation. The authors show that silencing Tac2 neurons in the amygdala of male mice reduces fear expression, while fear expression in female mice is increased when manipulations are made during proestrus.
format article
author A. Florido
E. R. Velasco
C. M. Soto-Faguás
A. Gomez-Gomez
L. Perez-Caballero
P. Molina
R. Nadal
O. J. Pozo
C. A. Saura
R. Andero
author_facet A. Florido
E. R. Velasco
C. M. Soto-Faguás
A. Gomez-Gomez
L. Perez-Caballero
P. Molina
R. Nadal
O. J. Pozo
C. A. Saura
R. Andero
author_sort A. Florido
title Sex differences in fear memory consolidation via Tac2 signaling in mice
title_short Sex differences in fear memory consolidation via Tac2 signaling in mice
title_full Sex differences in fear memory consolidation via Tac2 signaling in mice
title_fullStr Sex differences in fear memory consolidation via Tac2 signaling in mice
title_full_unstemmed Sex differences in fear memory consolidation via Tac2 signaling in mice
title_sort sex differences in fear memory consolidation via tac2 signaling in mice
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/069d3bc10a55439ba681f05b81c4f6bc
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