Lgr5+ telocytes are a signaling source at the intestinal villus tip

Epithelial gene expression has been shown to be zonated along the crypt-villus axis, but mechanisms shaping this spatial variability were unknown. Here, Bahar Halpern et al. uncover zonation of mesenchymal cells, including Lgr5+ telocytes, which regulate epithelial gene expression at the villus tip.

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Autores principales:	Keren Bahar Halpern, Hassan Massalha, Rachel K. Zwick, Andreas E. Moor, David Castillo-Azofeifa, Milena Rozenberg, Lydia Farack, Adi Egozi, Dan R. Miller, Inna Averbukh, Yotam Harnik, Noa Weinberg-Corem, Frederic J. de Sauvage, Ido Amit, Ophir D. Klein, Michal Shoshkes-Carmel, Shalev Itzkovitz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/06a4059134d14359ba2c09cd1b2ad006
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spelling	oai:doaj.org-article:06a4059134d14359ba2c09cd1b2ad0062021-12-02T14:42:28ZLgr5+ telocytes are a signaling source at the intestinal villus tip10.1038/s41467-020-15714-x2041-1723https://doaj.org/article/06a4059134d14359ba2c09cd1b2ad0062020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15714-xhttps://doaj.org/toc/2041-1723Epithelial gene expression has been shown to be zonated along the crypt-villus axis, but mechanisms shaping this spatial variability were unknown. Here, Bahar Halpern et al. uncover zonation of mesenchymal cells, including Lgr5+ telocytes, which regulate epithelial gene expression at the villus tip.Keren Bahar HalpernHassan MassalhaRachel K. ZwickAndreas E. MoorDavid Castillo-AzofeifaMilena RozenbergLydia FarackAdi EgoziDan R. MillerInna AverbukhYotam HarnikNoa Weinberg-CoremFrederic J. de SauvageIdo AmitOphir D. KleinMichal Shoshkes-CarmelShalev ItzkovitzNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Keren Bahar Halpern Hassan Massalha Rachel K. Zwick Andreas E. Moor David Castillo-Azofeifa Milena Rozenberg Lydia Farack Adi Egozi Dan R. Miller Inna Averbukh Yotam Harnik Noa Weinberg-Corem Frederic J. de Sauvage Ido Amit Ophir D. Klein Michal Shoshkes-Carmel Shalev Itzkovitz Lgr5+ telocytes are a signaling source at the intestinal villus tip
description	Epithelial gene expression has been shown to be zonated along the crypt-villus axis, but mechanisms shaping this spatial variability were unknown. Here, Bahar Halpern et al. uncover zonation of mesenchymal cells, including Lgr5+ telocytes, which regulate epithelial gene expression at the villus tip.
format	article
author	Keren Bahar Halpern Hassan Massalha Rachel K. Zwick Andreas E. Moor David Castillo-Azofeifa Milena Rozenberg Lydia Farack Adi Egozi Dan R. Miller Inna Averbukh Yotam Harnik Noa Weinberg-Corem Frederic J. de Sauvage Ido Amit Ophir D. Klein Michal Shoshkes-Carmel Shalev Itzkovitz
author_facet	Keren Bahar Halpern Hassan Massalha Rachel K. Zwick Andreas E. Moor David Castillo-Azofeifa Milena Rozenberg Lydia Farack Adi Egozi Dan R. Miller Inna Averbukh Yotam Harnik Noa Weinberg-Corem Frederic J. de Sauvage Ido Amit Ophir D. Klein Michal Shoshkes-Carmel Shalev Itzkovitz
author_sort	Keren Bahar Halpern
title	Lgr5+ telocytes are a signaling source at the intestinal villus tip
title_short	Lgr5+ telocytes are a signaling source at the intestinal villus tip
title_full	Lgr5+ telocytes are a signaling source at the intestinal villus tip
title_fullStr	Lgr5+ telocytes are a signaling source at the intestinal villus tip
title_full_unstemmed	Lgr5+ telocytes are a signaling source at the intestinal villus tip
title_sort	lgr5+ telocytes are a signaling source at the intestinal villus tip
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/06a4059134d14359ba2c09cd1b2ad006
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Lgr5+ telocytes are a signaling source at the intestinal villus tip

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