Age-dependent appearance of SARS-CoV-2 entry sites in mouse chemosensory systems reflects COVID-19 anosmia-ageusia symptoms

Brechbühl et al characterise the gene and protein expression of ACE2/TMPRSS2 in the mouse olfactory and gustatory cells, which reveals that SARS-CoV-2 target cells are of basal and sensory origin. They also demonstrate an age-dependent appearance of viral entry-sites, which could inform the use of m...

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Autores principales:	Julien Brechbühl, Ana Catarina Lopes, Dean Wood, Sofiane Bouteiller, Aurélie de Vallière, Chantal Verdumo, Marie-Christine Broillet
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/06aa80b59488459288a1f04810b31b74
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spelling	oai:doaj.org-article:06aa80b59488459288a1f04810b31b742021-12-02T16:14:15ZAge-dependent appearance of SARS-CoV-2 entry sites in mouse chemosensory systems reflects COVID-19 anosmia-ageusia symptoms10.1038/s42003-021-02410-92399-3642https://doaj.org/article/06aa80b59488459288a1f04810b31b742021-07-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02410-9https://doaj.org/toc/2399-3642Brechbühl et al characterise the gene and protein expression of ACE2/TMPRSS2 in the mouse olfactory and gustatory cells, which reveals that SARS-CoV-2 target cells are of basal and sensory origin. They also demonstrate an age-dependent appearance of viral entry-sites, which could inform the use of mouse models in the investigation of SARS-CoV-2 effects on olfaction.Julien BrechbühlAna Catarina LopesDean WoodSofiane BouteillerAurélie de VallièreChantal VerdumoMarie-Christine BroilletNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Julien Brechbühl Ana Catarina Lopes Dean Wood Sofiane Bouteiller Aurélie de Vallière Chantal Verdumo Marie-Christine Broillet Age-dependent appearance of SARS-CoV-2 entry sites in mouse chemosensory systems reflects COVID-19 anosmia-ageusia symptoms
description	Brechbühl et al characterise the gene and protein expression of ACE2/TMPRSS2 in the mouse olfactory and gustatory cells, which reveals that SARS-CoV-2 target cells are of basal and sensory origin. They also demonstrate an age-dependent appearance of viral entry-sites, which could inform the use of mouse models in the investigation of SARS-CoV-2 effects on olfaction.
format	article
author	Julien Brechbühl Ana Catarina Lopes Dean Wood Sofiane Bouteiller Aurélie de Vallière Chantal Verdumo Marie-Christine Broillet
author_facet	Julien Brechbühl Ana Catarina Lopes Dean Wood Sofiane Bouteiller Aurélie de Vallière Chantal Verdumo Marie-Christine Broillet
author_sort	Julien Brechbühl
title	Age-dependent appearance of SARS-CoV-2 entry sites in mouse chemosensory systems reflects COVID-19 anosmia-ageusia symptoms
title_short	Age-dependent appearance of SARS-CoV-2 entry sites in mouse chemosensory systems reflects COVID-19 anosmia-ageusia symptoms
title_full	Age-dependent appearance of SARS-CoV-2 entry sites in mouse chemosensory systems reflects COVID-19 anosmia-ageusia symptoms
title_fullStr	Age-dependent appearance of SARS-CoV-2 entry sites in mouse chemosensory systems reflects COVID-19 anosmia-ageusia symptoms
title_full_unstemmed	Age-dependent appearance of SARS-CoV-2 entry sites in mouse chemosensory systems reflects COVID-19 anosmia-ageusia symptoms
title_sort	age-dependent appearance of sars-cov-2 entry sites in mouse chemosensory systems reflects covid-19 anosmia-ageusia symptoms
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/06aa80b59488459288a1f04810b31b74
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Age-dependent appearance of SARS-CoV-2 entry sites in mouse chemosensory systems reflects COVID-19 anosmia-ageusia symptoms

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