Nopal (Opuntia ficus indica) protects from metabolic endotoxemia by modifying gut microbiota in obese rats fed high fat/sucrose diet

Abstract Current efforts are directed to reducing the gut dysbiosis and inflammation produced by obesity. The purpose of this study was to investigate whether consuming nopal, a vegetable rich in dietary fibre, vitamin C, and polyphenols can reduce the metabolic consequences of obesity by modifying...

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Autores principales:	Mónica Sánchez-Tapia, Miriam Aguilar-López, Claudia Pérez-Cruz, Edgar Pichardo-Ontiveros, Mei Wang, Sharon M. Donovan, Armando R. Tovar, Nimbe Torres
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/06ab227c1d1446be9db9de96ffd64dfe
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spelling	oai:doaj.org-article:06ab227c1d1446be9db9de96ffd64dfe2021-12-02T15:06:04ZNopal (Opuntia ficus indica) protects from metabolic endotoxemia by modifying gut microbiota in obese rats fed high fat/sucrose diet10.1038/s41598-017-05096-42045-2322https://doaj.org/article/06ab227c1d1446be9db9de96ffd64dfe2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05096-4https://doaj.org/toc/2045-2322Abstract Current efforts are directed to reducing the gut dysbiosis and inflammation produced by obesity. The purpose of this study was to investigate whether consuming nopal, a vegetable rich in dietary fibre, vitamin C, and polyphenols can reduce the metabolic consequences of obesity by modifying the gut microbiota and preventing metabolic endotoxemia in rats fed a high fat and sucrose diet. With this aim, rats were fed a high fat diet with 5% sucrose in the drinking water (HFS) for 7 months and then were fed for 1 month with HFS + 5% nopal (HFS + N). The composition of gut microbiota was assessed by sequencing the 16S rRNA gene. Nopal modified gut microbiota and increased intestinal occludin-1 in the HFS + N group. This was associated with a decrease in metabolic endotoxemia, glucose insulinotropic peptide, glucose intolerance, lipogenesis, and metabolic inflexibility. These changes were accompanied by reduced hepatic steatosis and oxidative stress in adipose tissue and brain, and improved cognitive function, associated with an increase in B. fragilis. This study supports the use of nopal as a functional food and prebiotic for its ability to modify gut microbiota and to reduce metabolic endotoxemia and other obesity-related biochemical abnormalities.Mónica Sánchez-TapiaMiriam Aguilar-LópezClaudia Pérez-CruzEdgar Pichardo-OntiverosMei WangSharon M. DonovanArmando R. TovarNimbe TorresNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-16 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mónica Sánchez-Tapia Miriam Aguilar-López Claudia Pérez-Cruz Edgar Pichardo-Ontiveros Mei Wang Sharon M. Donovan Armando R. Tovar Nimbe Torres Nopal (Opuntia ficus indica) protects from metabolic endotoxemia by modifying gut microbiota in obese rats fed high fat/sucrose diet
description	Abstract Current efforts are directed to reducing the gut dysbiosis and inflammation produced by obesity. The purpose of this study was to investigate whether consuming nopal, a vegetable rich in dietary fibre, vitamin C, and polyphenols can reduce the metabolic consequences of obesity by modifying the gut microbiota and preventing metabolic endotoxemia in rats fed a high fat and sucrose diet. With this aim, rats were fed a high fat diet with 5% sucrose in the drinking water (HFS) for 7 months and then were fed for 1 month with HFS + 5% nopal (HFS + N). The composition of gut microbiota was assessed by sequencing the 16S rRNA gene. Nopal modified gut microbiota and increased intestinal occludin-1 in the HFS + N group. This was associated with a decrease in metabolic endotoxemia, glucose insulinotropic peptide, glucose intolerance, lipogenesis, and metabolic inflexibility. These changes were accompanied by reduced hepatic steatosis and oxidative stress in adipose tissue and brain, and improved cognitive function, associated with an increase in B. fragilis. This study supports the use of nopal as a functional food and prebiotic for its ability to modify gut microbiota and to reduce metabolic endotoxemia and other obesity-related biochemical abnormalities.
format	article
author	Mónica Sánchez-Tapia Miriam Aguilar-López Claudia Pérez-Cruz Edgar Pichardo-Ontiveros Mei Wang Sharon M. Donovan Armando R. Tovar Nimbe Torres
author_facet	Mónica Sánchez-Tapia Miriam Aguilar-López Claudia Pérez-Cruz Edgar Pichardo-Ontiveros Mei Wang Sharon M. Donovan Armando R. Tovar Nimbe Torres
author_sort	Mónica Sánchez-Tapia
title	Nopal (Opuntia ficus indica) protects from metabolic endotoxemia by modifying gut microbiota in obese rats fed high fat/sucrose diet
title_short	Nopal (Opuntia ficus indica) protects from metabolic endotoxemia by modifying gut microbiota in obese rats fed high fat/sucrose diet
title_full	Nopal (Opuntia ficus indica) protects from metabolic endotoxemia by modifying gut microbiota in obese rats fed high fat/sucrose diet
title_fullStr	Nopal (Opuntia ficus indica) protects from metabolic endotoxemia by modifying gut microbiota in obese rats fed high fat/sucrose diet
title_full_unstemmed	Nopal (Opuntia ficus indica) protects from metabolic endotoxemia by modifying gut microbiota in obese rats fed high fat/sucrose diet
title_sort	nopal (opuntia ficus indica) protects from metabolic endotoxemia by modifying gut microbiota in obese rats fed high fat/sucrose diet
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/06ab227c1d1446be9db9de96ffd64dfe
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Nopal (Opuntia ficus indica) protects from metabolic endotoxemia by modifying gut microbiota in obese rats fed high fat/sucrose diet

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