The effect of trauma and PTSD on telomere length: An exploratory study in people exposed to combat trauma

Abstract Telomere length has been suggested to be a cellular marker for age-related diseases as well as psychosocial stress. The present study investigated whether telomere length is associated with post-traumatic stress disorder (PTSD) among veterans exposed to combat trauma in the Vietnam War. The...

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Autores principales:	Tae Yong Kim, Se Joo Kim, Jong Rak Choi, Seung-Tae Lee, Jieun Kim, In Sik Hwang, Hae Gyung Chung, Jin Hee Choi, Hae Won Kim, Se Hyun Kim, Jee In Kang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/06abcaeb9f3e49b8bcea20e678954a33
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spelling	oai:doaj.org-article:06abcaeb9f3e49b8bcea20e678954a332021-12-02T12:31:53ZThe effect of trauma and PTSD on telomere length: An exploratory study in people exposed to combat trauma10.1038/s41598-017-04682-w2045-2322https://doaj.org/article/06abcaeb9f3e49b8bcea20e678954a332017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-04682-whttps://doaj.org/toc/2045-2322Abstract Telomere length has been suggested to be a cellular marker for age-related diseases as well as psychosocial stress. The present study investigated whether telomere length is associated with post-traumatic stress disorder (PTSD) among veterans exposed to combat trauma in the Vietnam War. The potentially associated factors on cellular aging were considered. Korean male veterans with (n = 122) and without (n = 120) PTSD were included and leukocyte telomere length was measured with a quantitative PCR-based technique. As a whole, no significant difference in telomere length was found between PTSD and non-PTSD groups. In linear regression analysis stratified by trauma levels, among veterans exposed to severe combat (n = 45), PTSD status (B = −1.176, t = −2.259, p = 0.029), antidepressant use (B = 0.168, t = 2.528, p = 0.015), and education level (B = 0.019, t = 2.369, p = 0.023) affected telomere length. However, among veterans with light-to-moderate combat exposure (n = 197), only age (B = −0.007, t = −2.434, p = 0.016) and education level (B = 0.010, t = 2.295, p = 0.023) were associated with telomere length. In the Post-hoc analysis, antidepressant use was associated with longer telomere length in subjects exposed to severe combat. Our exploratory results suggest that PTSD status in combination with severe trauma may be associated with accelerated telomere shortening, and that antidepressant use may have a protective effect on telomere dynamics.Tae Yong KimSe Joo KimJong Rak ChoiSeung-Tae LeeJieun KimIn Sik HwangHae Gyung ChungJin Hee ChoiHae Won KimSe Hyun KimJee In KangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tae Yong Kim Se Joo Kim Jong Rak Choi Seung-Tae Lee Jieun Kim In Sik Hwang Hae Gyung Chung Jin Hee Choi Hae Won Kim Se Hyun Kim Jee In Kang The effect of trauma and PTSD on telomere length: An exploratory study in people exposed to combat trauma
description	Abstract Telomere length has been suggested to be a cellular marker for age-related diseases as well as psychosocial stress. The present study investigated whether telomere length is associated with post-traumatic stress disorder (PTSD) among veterans exposed to combat trauma in the Vietnam War. The potentially associated factors on cellular aging were considered. Korean male veterans with (n = 122) and without (n = 120) PTSD were included and leukocyte telomere length was measured with a quantitative PCR-based technique. As a whole, no significant difference in telomere length was found between PTSD and non-PTSD groups. In linear regression analysis stratified by trauma levels, among veterans exposed to severe combat (n = 45), PTSD status (B = −1.176, t = −2.259, p = 0.029), antidepressant use (B = 0.168, t = 2.528, p = 0.015), and education level (B = 0.019, t = 2.369, p = 0.023) affected telomere length. However, among veterans with light-to-moderate combat exposure (n = 197), only age (B = −0.007, t = −2.434, p = 0.016) and education level (B = 0.010, t = 2.295, p = 0.023) were associated with telomere length. In the Post-hoc analysis, antidepressant use was associated with longer telomere length in subjects exposed to severe combat. Our exploratory results suggest that PTSD status in combination with severe trauma may be associated with accelerated telomere shortening, and that antidepressant use may have a protective effect on telomere dynamics.
format	article
author	Tae Yong Kim Se Joo Kim Jong Rak Choi Seung-Tae Lee Jieun Kim In Sik Hwang Hae Gyung Chung Jin Hee Choi Hae Won Kim Se Hyun Kim Jee In Kang
author_facet	Tae Yong Kim Se Joo Kim Jong Rak Choi Seung-Tae Lee Jieun Kim In Sik Hwang Hae Gyung Chung Jin Hee Choi Hae Won Kim Se Hyun Kim Jee In Kang
author_sort	Tae Yong Kim
title	The effect of trauma and PTSD on telomere length: An exploratory study in people exposed to combat trauma
title_short	The effect of trauma and PTSD on telomere length: An exploratory study in people exposed to combat trauma
title_full	The effect of trauma and PTSD on telomere length: An exploratory study in people exposed to combat trauma
title_fullStr	The effect of trauma and PTSD on telomere length: An exploratory study in people exposed to combat trauma
title_full_unstemmed	The effect of trauma and PTSD on telomere length: An exploratory study in people exposed to combat trauma
title_sort	effect of trauma and ptsd on telomere length: an exploratory study in people exposed to combat trauma
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/06abcaeb9f3e49b8bcea20e678954a33
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The effect of trauma and PTSD on telomere length: An exploratory study in people exposed to combat trauma

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