Increases in adipose tissue and muscle function are longitudinally associated with better quality of life in colorectal cancer survivors

Abstract Colorectal cancer (CRC) survivors need evidence-based guidelines pertaining to post-treatment body composition, which could benefit health-related quality of life (HRQoL). We aimed to describe the course of several body composition measures, and to assess longitudinal associations of these...

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Autores principales:	Marlou-Floor Kenkhuis, Eline H. van Roekel, Janna L. Koole, José J. L. Breedveld-Peters, Stéphanie O. Breukink, Maryska L. G. Janssen-Heijnen, Eric T. P. Keulen, Fränzel J. B. van Duijnhoven, Floortje Mols, Matty P. Weijenberg, Martijn J. L. Bours
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/06adc25c935a46aa95e39885d43a7c27
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spelling	oai:doaj.org-article:06adc25c935a46aa95e39885d43a7c272021-12-02T17:41:27ZIncreases in adipose tissue and muscle function are longitudinally associated with better quality of life in colorectal cancer survivors10.1038/s41598-021-91709-y2045-2322https://doaj.org/article/06adc25c935a46aa95e39885d43a7c272021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91709-yhttps://doaj.org/toc/2045-2322Abstract Colorectal cancer (CRC) survivors need evidence-based guidelines pertaining to post-treatment body composition, which could benefit health-related quality of life (HRQoL). We aimed to describe the course of several body composition measures, and to assess longitudinal associations of these measures with HRQoL, fatigue and chemotherapy-induced peripheral neuropathy (CIPN). In a prospective cohort among stage I–III CRC survivors (n = 459), five repeated home visits from diagnosis up to 24 months post-treatment were executed. Body mass index (BMI), waist circumference and fat percentage were assessed as measures of adiposity, and muscle arm circumference and handgrip strength as measures of muscle mass and function. We applied linear mixed-models to describe changes in body composition over time and to analyze overall longitudinal associations. Of included participants, 44% was overweight and 31% was obese at diagnosis. All body composition measures followed similar trends, decreasing from diagnosis to 6 weeks and then increasing up to 24 months post-treatment. In confounder-adjusted mixed models, increases in adipose tissue and muscle function were longitudinally associated with better HRQoL and less fatigue, regardless of pre-treatment body composition. With regards to improving HRQoL, decreasing fatigue and CIPN, clinical practice should also focus on restoring body tissues after CRC treatment. Trial registration: NTR7099.Marlou-Floor KenkhuisEline H. van RoekelJanna L. KooleJosé J. L. Breedveld-PetersStéphanie O. BreukinkMaryska L. G. Janssen-HeijnenEric T. P. KeulenFränzel J. B. van DuijnhovenFloortje MolsMatty P. WeijenbergMartijn J. L. BoursNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Marlou-Floor Kenkhuis Eline H. van Roekel Janna L. Koole José J. L. Breedveld-Peters Stéphanie O. Breukink Maryska L. G. Janssen-Heijnen Eric T. P. Keulen Fränzel J. B. van Duijnhoven Floortje Mols Matty P. Weijenberg Martijn J. L. Bours Increases in adipose tissue and muscle function are longitudinally associated with better quality of life in colorectal cancer survivors
description	Abstract Colorectal cancer (CRC) survivors need evidence-based guidelines pertaining to post-treatment body composition, which could benefit health-related quality of life (HRQoL). We aimed to describe the course of several body composition measures, and to assess longitudinal associations of these measures with HRQoL, fatigue and chemotherapy-induced peripheral neuropathy (CIPN). In a prospective cohort among stage I–III CRC survivors (n = 459), five repeated home visits from diagnosis up to 24 months post-treatment were executed. Body mass index (BMI), waist circumference and fat percentage were assessed as measures of adiposity, and muscle arm circumference and handgrip strength as measures of muscle mass and function. We applied linear mixed-models to describe changes in body composition over time and to analyze overall longitudinal associations. Of included participants, 44% was overweight and 31% was obese at diagnosis. All body composition measures followed similar trends, decreasing from diagnosis to 6 weeks and then increasing up to 24 months post-treatment. In confounder-adjusted mixed models, increases in adipose tissue and muscle function were longitudinally associated with better HRQoL and less fatigue, regardless of pre-treatment body composition. With regards to improving HRQoL, decreasing fatigue and CIPN, clinical practice should also focus on restoring body tissues after CRC treatment. Trial registration: NTR7099.
format	article
author	Marlou-Floor Kenkhuis Eline H. van Roekel Janna L. Koole José J. L. Breedveld-Peters Stéphanie O. Breukink Maryska L. G. Janssen-Heijnen Eric T. P. Keulen Fränzel J. B. van Duijnhoven Floortje Mols Matty P. Weijenberg Martijn J. L. Bours
author_facet	Marlou-Floor Kenkhuis Eline H. van Roekel Janna L. Koole José J. L. Breedveld-Peters Stéphanie O. Breukink Maryska L. G. Janssen-Heijnen Eric T. P. Keulen Fränzel J. B. van Duijnhoven Floortje Mols Matty P. Weijenberg Martijn J. L. Bours
author_sort	Marlou-Floor Kenkhuis
title	Increases in adipose tissue and muscle function are longitudinally associated with better quality of life in colorectal cancer survivors
title_short	Increases in adipose tissue and muscle function are longitudinally associated with better quality of life in colorectal cancer survivors
title_full	Increases in adipose tissue and muscle function are longitudinally associated with better quality of life in colorectal cancer survivors
title_fullStr	Increases in adipose tissue and muscle function are longitudinally associated with better quality of life in colorectal cancer survivors
title_full_unstemmed	Increases in adipose tissue and muscle function are longitudinally associated with better quality of life in colorectal cancer survivors
title_sort	increases in adipose tissue and muscle function are longitudinally associated with better quality of life in colorectal cancer survivors
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/06adc25c935a46aa95e39885d43a7c27
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Increases in adipose tissue and muscle function are longitudinally associated with better quality of life in colorectal cancer survivors

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