Tumor Cell Distinguishable Nanomedicine Integrating Chemotherapeutic Sensitization and Protection

Theoretically, with a high enough drug dosage, cancer cells could be eliminated. However, the dosages that can be administered are limited by the therapeutic efficacy and side effects of the given drug. Herein, a nanomedicine integrating chemotherapeutic sensitization and protection was developed to...

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Autores principales:	Sen Liu, Can Shen, Cheng Qian, Jianquan Wang, Zhongmei Yang, Yanchun Wei, Li Quan, Changjiang Pan, Yong Hu, Wei Ye
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	chemotherapy NIR-controlled release cell distinguishing chemotherapeutic sensitization chemotherapeutic protection Biotechnology TP248.13-248.65
Acceso en línea:	https://doaj.org/article/06b282931d6c4365bbccc1bf38c17398
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spelling	oai:doaj.org-article:06b282931d6c4365bbccc1bf38c173982021-11-10T09:56:33ZTumor Cell Distinguishable Nanomedicine Integrating Chemotherapeutic Sensitization and Protection2296-418510.3389/fbioe.2021.773021https://doaj.org/article/06b282931d6c4365bbccc1bf38c173982021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fbioe.2021.773021/fullhttps://doaj.org/toc/2296-4185Theoretically, with a high enough drug dosage, cancer cells could be eliminated. However, the dosages that can be administered are limited by the therapeutic efficacy and side effects of the given drug. Herein, a nanomedicine integrating chemotherapeutic sensitization and protection was developed to relieve the limitation of administration dosage and to improve the efficacy of chemotherapy. The nanomedicine was endowed with the function of synergistically controlled release of CO and drugs under near-infrared (NIR) light irradiation. CO photo-induced release system (COPIRS) was synthesized by constructing an electron excitation–electron transfer group–electron-induced CO release structure and was used as the hydrophobic part, and then hydrophilic polymer (polyethylene glycol; PEG) was introduced by a thermal-responsive groups (DA group), forming a near-infrared-induced burst-release nanocarrier. In vitro and in vivo experiments showed that the nanomedicine can distinguish between tumor and normal cells and regulates the resistance of these different cells through the controlled release of carbonic oxide (CO), simultaneously enhancing the efficacy of chemotherapy drugs on tumor cells and chemotherapeutic protection on normal cells. This strategy could solve the current limitations on dosages due to toxicity and provide a solution for tumor cure by chemotherapy.Sen LiuSen LiuCan ShenCheng QianJianquan WangZhongmei YangYanchun WeiLi QuanChangjiang PanYong HuWei YeFrontiers Media S.A.articlechemotherapyNIR-controlled releasecell distinguishingchemotherapeutic sensitizationchemotherapeutic protectionBiotechnologyTP248.13-248.65ENFrontiers in Bioengineering and Biotechnology, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	chemotherapy NIR-controlled release cell distinguishing chemotherapeutic sensitization chemotherapeutic protection Biotechnology TP248.13-248.65
spellingShingle	chemotherapy NIR-controlled release cell distinguishing chemotherapeutic sensitization chemotherapeutic protection Biotechnology TP248.13-248.65 Sen Liu Sen Liu Can Shen Cheng Qian Jianquan Wang Zhongmei Yang Yanchun Wei Li Quan Changjiang Pan Yong Hu Wei Ye Tumor Cell Distinguishable Nanomedicine Integrating Chemotherapeutic Sensitization and Protection
description	Theoretically, with a high enough drug dosage, cancer cells could be eliminated. However, the dosages that can be administered are limited by the therapeutic efficacy and side effects of the given drug. Herein, a nanomedicine integrating chemotherapeutic sensitization and protection was developed to relieve the limitation of administration dosage and to improve the efficacy of chemotherapy. The nanomedicine was endowed with the function of synergistically controlled release of CO and drugs under near-infrared (NIR) light irradiation. CO photo-induced release system (COPIRS) was synthesized by constructing an electron excitation–electron transfer group–electron-induced CO release structure and was used as the hydrophobic part, and then hydrophilic polymer (polyethylene glycol; PEG) was introduced by a thermal-responsive groups (DA group), forming a near-infrared-induced burst-release nanocarrier. In vitro and in vivo experiments showed that the nanomedicine can distinguish between tumor and normal cells and regulates the resistance of these different cells through the controlled release of carbonic oxide (CO), simultaneously enhancing the efficacy of chemotherapy drugs on tumor cells and chemotherapeutic protection on normal cells. This strategy could solve the current limitations on dosages due to toxicity and provide a solution for tumor cure by chemotherapy.
format	article
author	Sen Liu Sen Liu Can Shen Cheng Qian Jianquan Wang Zhongmei Yang Yanchun Wei Li Quan Changjiang Pan Yong Hu Wei Ye
author_facet	Sen Liu Sen Liu Can Shen Cheng Qian Jianquan Wang Zhongmei Yang Yanchun Wei Li Quan Changjiang Pan Yong Hu Wei Ye
author_sort	Sen Liu
title	Tumor Cell Distinguishable Nanomedicine Integrating Chemotherapeutic Sensitization and Protection
title_short	Tumor Cell Distinguishable Nanomedicine Integrating Chemotherapeutic Sensitization and Protection
title_full	Tumor Cell Distinguishable Nanomedicine Integrating Chemotherapeutic Sensitization and Protection
title_fullStr	Tumor Cell Distinguishable Nanomedicine Integrating Chemotherapeutic Sensitization and Protection
title_full_unstemmed	Tumor Cell Distinguishable Nanomedicine Integrating Chemotherapeutic Sensitization and Protection
title_sort	tumor cell distinguishable nanomedicine integrating chemotherapeutic sensitization and protection
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/06b282931d6c4365bbccc1bf38c17398
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Tumor Cell Distinguishable Nanomedicine Integrating Chemotherapeutic Sensitization and Protection

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