Antimicrobial related problems in patients undergoing renal dialysis in a university hospital

Objective: To detect antimicrobial drug-related problems (DRP) in adult patients undergoing renal dialysis in a university hospital. Methods: This is an observational and retrospective study in which were included patients hospitalized in antimicrobial therapy and submitted to renal replacement the...

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Autores principales:	Cristiane C. Santos, Elza A. Domingues
Formato:	article
Lenguaje:	EN PT
Publicado:	Sociedade Brasileira de Farmácia Hospitalar e Serviços de Saúde 2020
Materias:	Public aspects of medicine RA1-1270 Pharmacy and materia medica RS1-441 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/06b32c7839a94f50bb66644bfb98f2f4
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spelling	oai:doaj.org-article:06b32c7839a94f50bb66644bfb98f2f42021-11-28T02:46:14ZAntimicrobial related problems in patients undergoing renal dialysis in a university hospital10.30968/rbfhss.2019.104.03402179-59242316-7750https://doaj.org/article/06b32c7839a94f50bb66644bfb98f2f42020-03-01T00:00:00Zhttps://www.rbfhss.org.br/sbrafh/article/view/340https://doaj.org/toc/2179-5924https://doaj.org/toc/2316-7750 Objective: To detect antimicrobial drug-related problems (DRP) in adult patients undergoing renal dialysis in a university hospital. Methods: This is an observational and retrospective study in which were included patients hospitalized in antimicrobial therapy and submitted to renal replacement therapy (RRT) from January to August 2017. The study variables were collected on the first day that antimicrobial was administraded and hemodialysis was done. The Dáder Methodology was used to detect and classify the DRP and probable negative outcomes associated with medications (NOMs). Results: 85 patients were included, 62.4% (n=53) male, mean age 61.2 ± 15.2 years. An average of 2.6 ± 1.6 different antimicrobials prescribed per patient was observed, being the main class carbapenems (13.7%) and the main reason for antimicrobial use was sepsis (34.1%). The main DRPs found were: prescription error (45.1%), Y incompatibility (14.0%) and inadequate dosage (12.1%), median 6.0 (4-11) DRP per patient, minimum:1 and maximum:32. Regarding NOMs, the most frequent were quantitative insecurity (50.6%), non-quantitative insecurity (19.9%) and quantitative ineffectiveness (19.0%). Conclusions: All patients undergoing dialysis and antimicrobial therapy included in this study had at least one problem related to antimicrobial drugs and, therefore, one probable NOM. It was verified the need of a multiprofessional team working on the detection and prevention of avoidable problems, through the implantation of computerized systems, continuing education program, protocols and routines, allied with an institutional antimicrobial stewardship program. Cristiane C. SantosElza A. DominguesSociedade Brasileira de Farmácia Hospitalar e Serviços de SaúdearticlePublic aspects of medicineRA1-1270Pharmacy and materia medicaRS1-441Therapeutics. PharmacologyRM1-950ENPTRevista Brasileira de Farmácia Hospitalar e Serviços de Saúde, Vol 10, Iss 4 (2020)
institution	DOAJ
collection	DOAJ
language	EN PT
topic	Public aspects of medicine RA1-1270 Pharmacy and materia medica RS1-441 Therapeutics. Pharmacology RM1-950
spellingShingle	Public aspects of medicine RA1-1270 Pharmacy and materia medica RS1-441 Therapeutics. Pharmacology RM1-950 Cristiane C. Santos Elza A. Domingues Antimicrobial related problems in patients undergoing renal dialysis in a university hospital
description	Objective: To detect antimicrobial drug-related problems (DRP) in adult patients undergoing renal dialysis in a university hospital. Methods: This is an observational and retrospective study in which were included patients hospitalized in antimicrobial therapy and submitted to renal replacement therapy (RRT) from January to August 2017. The study variables were collected on the first day that antimicrobial was administraded and hemodialysis was done. The Dáder Methodology was used to detect and classify the DRP and probable negative outcomes associated with medications (NOMs). Results: 85 patients were included, 62.4% (n=53) male, mean age 61.2 ± 15.2 years. An average of 2.6 ± 1.6 different antimicrobials prescribed per patient was observed, being the main class carbapenems (13.7%) and the main reason for antimicrobial use was sepsis (34.1%). The main DRPs found were: prescription error (45.1%), Y incompatibility (14.0%) and inadequate dosage (12.1%), median 6.0 (4-11) DRP per patient, minimum:1 and maximum:32. Regarding NOMs, the most frequent were quantitative insecurity (50.6%), non-quantitative insecurity (19.9%) and quantitative ineffectiveness (19.0%). Conclusions: All patients undergoing dialysis and antimicrobial therapy included in this study had at least one problem related to antimicrobial drugs and, therefore, one probable NOM. It was verified the need of a multiprofessional team working on the detection and prevention of avoidable problems, through the implantation of computerized systems, continuing education program, protocols and routines, allied with an institutional antimicrobial stewardship program.
format	article
author	Cristiane C. Santos Elza A. Domingues
author_facet	Cristiane C. Santos Elza A. Domingues
author_sort	Cristiane C. Santos
title	Antimicrobial related problems in patients undergoing renal dialysis in a university hospital
title_short	Antimicrobial related problems in patients undergoing renal dialysis in a university hospital
title_full	Antimicrobial related problems in patients undergoing renal dialysis in a university hospital
title_fullStr	Antimicrobial related problems in patients undergoing renal dialysis in a university hospital
title_full_unstemmed	Antimicrobial related problems in patients undergoing renal dialysis in a university hospital
title_sort	antimicrobial related problems in patients undergoing renal dialysis in a university hospital
publisher	Sociedade Brasileira de Farmácia Hospitalar e Serviços de Saúde
publishDate	2020
url	https://doaj.org/article/06b32c7839a94f50bb66644bfb98f2f4
work_keys_str_mv	AT cristianecsantos antimicrobialrelatedproblemsinpatientsundergoingrenaldialysisinauniversityhospital AT elzaadomingues antimicrobialrelatedproblemsinpatientsundergoingrenaldialysisinauniversityhospital
_version_	1718408419345432576

Antimicrobial related problems in patients undergoing renal dialysis in a university hospital

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