Rhodopsin-cyclases for photocontrol of cGMP/cAMP and 2.3 Å structure of the adenylyl cyclase domain

Cyclic AMP and cGMP orchestrate a variety of cellular responses. Here, authors characterize the cGMP producing rhodopsin-guanylyl cyclase from C. anguillulae and derived adenylyl cyclase by a biochemical and structural approach which demonstrates the usability of these cyclases for optogenetic appli...

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Autores principales:	Ulrike Scheib, Matthias Broser, Oana M. Constantin, Shang Yang, Shiqiang Gao, Shatanik Mukherjee, Katja Stehfest, Georg Nagel, Christine E. Gee, Peter Hegemann
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/06b7a3c5022e4c038a921dde8d876ca7
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spelling	oai:doaj.org-article:06b7a3c5022e4c038a921dde8d876ca72021-12-02T17:33:03ZRhodopsin-cyclases for photocontrol of cGMP/cAMP and 2.3 Å structure of the adenylyl cyclase domain10.1038/s41467-018-04428-w2041-1723https://doaj.org/article/06b7a3c5022e4c038a921dde8d876ca72018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04428-whttps://doaj.org/toc/2041-1723Cyclic AMP and cGMP orchestrate a variety of cellular responses. Here, authors characterize the cGMP producing rhodopsin-guanylyl cyclase from C. anguillulae and derived adenylyl cyclase by a biochemical and structural approach which demonstrates the usability of these cyclases for optogenetic applications.Ulrike ScheibMatthias BroserOana M. ConstantinShang YangShiqiang GaoShatanik MukherjeeKatja StehfestGeorg NagelChristine E. GeePeter HegemannNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ulrike Scheib Matthias Broser Oana M. Constantin Shang Yang Shiqiang Gao Shatanik Mukherjee Katja Stehfest Georg Nagel Christine E. Gee Peter Hegemann Rhodopsin-cyclases for photocontrol of cGMP/cAMP and 2.3 Å structure of the adenylyl cyclase domain
description	Cyclic AMP and cGMP orchestrate a variety of cellular responses. Here, authors characterize the cGMP producing rhodopsin-guanylyl cyclase from C. anguillulae and derived adenylyl cyclase by a biochemical and structural approach which demonstrates the usability of these cyclases for optogenetic applications.
format	article
author	Ulrike Scheib Matthias Broser Oana M. Constantin Shang Yang Shiqiang Gao Shatanik Mukherjee Katja Stehfest Georg Nagel Christine E. Gee Peter Hegemann
author_facet	Ulrike Scheib Matthias Broser Oana M. Constantin Shang Yang Shiqiang Gao Shatanik Mukherjee Katja Stehfest Georg Nagel Christine E. Gee Peter Hegemann
author_sort	Ulrike Scheib
title	Rhodopsin-cyclases for photocontrol of cGMP/cAMP and 2.3 Å structure of the adenylyl cyclase domain
title_short	Rhodopsin-cyclases for photocontrol of cGMP/cAMP and 2.3 Å structure of the adenylyl cyclase domain
title_full	Rhodopsin-cyclases for photocontrol of cGMP/cAMP and 2.3 Å structure of the adenylyl cyclase domain
title_fullStr	Rhodopsin-cyclases for photocontrol of cGMP/cAMP and 2.3 Å structure of the adenylyl cyclase domain
title_full_unstemmed	Rhodopsin-cyclases for photocontrol of cGMP/cAMP and 2.3 Å structure of the adenylyl cyclase domain
title_sort	rhodopsin-cyclases for photocontrol of cgmp/camp and 2.3 å structure of the adenylyl cyclase domain
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/06b7a3c5022e4c038a921dde8d876ca7
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Rhodopsin-cyclases for photocontrol of cGMP/cAMP and 2.3 Å structure of the adenylyl cyclase domain

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