An N-myristoylated globin with a redox-sensing function that regulates the defecation cycle in Caenorhabditis elegans.

Globins occur in all kingdoms of life where they fulfill a wide variety of functions. In the past they used to be primarily characterized as oxygen transport/storage proteins, but since the discovery of new members of the globin family like neuroglobin and cytoglobin, more diverse and complex functi...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Lesley Tilleman, Sasha De Henau, Martje Pauwels, Nora Nagy, Isabel Pintelon, Bart P Braeckman, Karolien De Wael, Sabine Van Doorslaer, Dirk Adriaensen, Jean-Pierre Timmermans, Luc Moens, Sylvia Dewilde
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/06ba03dc90a6484f97b231121d22dbe1
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:06ba03dc90a6484f97b231121d22dbe1
record_format	dspace
spelling	oai:doaj.org-article:06ba03dc90a6484f97b231121d22dbe12021-11-18T08:05:30ZAn N-myristoylated globin with a redox-sensing function that regulates the defecation cycle in Caenorhabditis elegans.1932-620310.1371/journal.pone.0048768https://doaj.org/article/06ba03dc90a6484f97b231121d22dbe12012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23251335/?tool=EBIhttps://doaj.org/toc/1932-6203Globins occur in all kingdoms of life where they fulfill a wide variety of functions. In the past they used to be primarily characterized as oxygen transport/storage proteins, but since the discovery of new members of the globin family like neuroglobin and cytoglobin, more diverse and complex functions have been assigned to this heterogeneous family. Here we propose a function for a membrane-bound globin of C. elegans, GLB-26. This globin was predicted to be myristoylated at its N-terminus, a post-translational modification only recently described in the globin family. In vivo, this globin is found in the membrane of the head mesodermal cell and in the tail stomato-intestinal and anal depressor muscle cells. Since GLB-26 is almost directly oxidized when exposed to oxygen, we postulate a possible function as electron transfer protein. Phenotypical studies show that GLB-26 takes part in regulating the length of the defecation cycle in C. elegans under oxidative stress conditions.Lesley TillemanSasha De HenauMartje PauwelsNora NagyIsabel PintelonBart P BraeckmanKarolien De WaelSabine Van DoorslaerDirk AdriaensenJean-Pierre TimmermansLuc MoensSylvia DewildePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 12, p e48768 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lesley Tilleman Sasha De Henau Martje Pauwels Nora Nagy Isabel Pintelon Bart P Braeckman Karolien De Wael Sabine Van Doorslaer Dirk Adriaensen Jean-Pierre Timmermans Luc Moens Sylvia Dewilde An N-myristoylated globin with a redox-sensing function that regulates the defecation cycle in Caenorhabditis elegans.
description	Globins occur in all kingdoms of life where they fulfill a wide variety of functions. In the past they used to be primarily characterized as oxygen transport/storage proteins, but since the discovery of new members of the globin family like neuroglobin and cytoglobin, more diverse and complex functions have been assigned to this heterogeneous family. Here we propose a function for a membrane-bound globin of C. elegans, GLB-26. This globin was predicted to be myristoylated at its N-terminus, a post-translational modification only recently described in the globin family. In vivo, this globin is found in the membrane of the head mesodermal cell and in the tail stomato-intestinal and anal depressor muscle cells. Since GLB-26 is almost directly oxidized when exposed to oxygen, we postulate a possible function as electron transfer protein. Phenotypical studies show that GLB-26 takes part in regulating the length of the defecation cycle in C. elegans under oxidative stress conditions.
format	article
author	Lesley Tilleman Sasha De Henau Martje Pauwels Nora Nagy Isabel Pintelon Bart P Braeckman Karolien De Wael Sabine Van Doorslaer Dirk Adriaensen Jean-Pierre Timmermans Luc Moens Sylvia Dewilde
author_facet	Lesley Tilleman Sasha De Henau Martje Pauwels Nora Nagy Isabel Pintelon Bart P Braeckman Karolien De Wael Sabine Van Doorslaer Dirk Adriaensen Jean-Pierre Timmermans Luc Moens Sylvia Dewilde
author_sort	Lesley Tilleman
title	An N-myristoylated globin with a redox-sensing function that regulates the defecation cycle in Caenorhabditis elegans.
title_short	An N-myristoylated globin with a redox-sensing function that regulates the defecation cycle in Caenorhabditis elegans.
title_full	An N-myristoylated globin with a redox-sensing function that regulates the defecation cycle in Caenorhabditis elegans.
title_fullStr	An N-myristoylated globin with a redox-sensing function that regulates the defecation cycle in Caenorhabditis elegans.
title_full_unstemmed	An N-myristoylated globin with a redox-sensing function that regulates the defecation cycle in Caenorhabditis elegans.
title_sort	n-myristoylated globin with a redox-sensing function that regulates the defecation cycle in caenorhabditis elegans.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/06ba03dc90a6484f97b231121d22dbe1
work_keys_str_mv	AT lesleytilleman annmyristoylatedglobinwitharedoxsensingfunctionthatregulatesthedefecationcycleincaenorhabditiselegans AT sashadehenau annmyristoylatedglobinwitharedoxsensingfunctionthatregulatesthedefecationcycleincaenorhabditiselegans AT martjepauwels annmyristoylatedglobinwitharedoxsensingfunctionthatregulatesthedefecationcycleincaenorhabditiselegans AT noranagy annmyristoylatedglobinwitharedoxsensingfunctionthatregulatesthedefecationcycleincaenorhabditiselegans AT isabelpintelon annmyristoylatedglobinwitharedoxsensingfunctionthatregulatesthedefecationcycleincaenorhabditiselegans AT bartpbraeckman annmyristoylatedglobinwitharedoxsensingfunctionthatregulatesthedefecationcycleincaenorhabditiselegans AT karoliendewael annmyristoylatedglobinwitharedoxsensingfunctionthatregulatesthedefecationcycleincaenorhabditiselegans AT sabinevandoorslaer annmyristoylatedglobinwitharedoxsensingfunctionthatregulatesthedefecationcycleincaenorhabditiselegans AT dirkadriaensen annmyristoylatedglobinwitharedoxsensingfunctionthatregulatesthedefecationcycleincaenorhabditiselegans AT jeanpierretimmermans annmyristoylatedglobinwitharedoxsensingfunctionthatregulatesthedefecationcycleincaenorhabditiselegans AT lucmoens annmyristoylatedglobinwitharedoxsensingfunctionthatregulatesthedefecationcycleincaenorhabditiselegans AT sylviadewilde annmyristoylatedglobinwitharedoxsensingfunctionthatregulatesthedefecationcycleincaenorhabditiselegans AT lesleytilleman nmyristoylatedglobinwitharedoxsensingfunctionthatregulatesthedefecationcycleincaenorhabditiselegans AT sashadehenau nmyristoylatedglobinwitharedoxsensingfunctionthatregulatesthedefecationcycleincaenorhabditiselegans AT martjepauwels nmyristoylatedglobinwitharedoxsensingfunctionthatregulatesthedefecationcycleincaenorhabditiselegans AT noranagy nmyristoylatedglobinwitharedoxsensingfunctionthatregulatesthedefecationcycleincaenorhabditiselegans AT isabelpintelon nmyristoylatedglobinwitharedoxsensingfunctionthatregulatesthedefecationcycleincaenorhabditiselegans AT bartpbraeckman nmyristoylatedglobinwitharedoxsensingfunctionthatregulatesthedefecationcycleincaenorhabditiselegans AT karoliendewael nmyristoylatedglobinwitharedoxsensingfunctionthatregulatesthedefecationcycleincaenorhabditiselegans AT sabinevandoorslaer nmyristoylatedglobinwitharedoxsensingfunctionthatregulatesthedefecationcycleincaenorhabditiselegans AT dirkadriaensen nmyristoylatedglobinwitharedoxsensingfunctionthatregulatesthedefecationcycleincaenorhabditiselegans AT jeanpierretimmermans nmyristoylatedglobinwitharedoxsensingfunctionthatregulatesthedefecationcycleincaenorhabditiselegans AT lucmoens nmyristoylatedglobinwitharedoxsensingfunctionthatregulatesthedefecationcycleincaenorhabditiselegans AT sylviadewilde nmyristoylatedglobinwitharedoxsensingfunctionthatregulatesthedefecationcycleincaenorhabditiselegans
_version_	1718422208882147328

An N-myristoylated globin with a redox-sensing function that regulates the defecation cycle in Caenorhabditis elegans.

Ejemplares similares