INFLUENCE OF SOLUBLE PLACENTAL TISSUE-DERIVED MOLECULES UPON EXPRESSION OF ADHESION MOLECULES BY EA.HY926 ENDOTHELIAL CELLS

Abstract. Leukocyte recruitment to placental tissue is an important factor of its development. In this respect, adhesion molecules at the endothelial cell surface represent a key determining factor of leukocyte adhesion and their trans-endothelial migration. The goal of investigation w...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	O. I. Stepanova, T. U. Lvova, E. N. Purbeeva, M. I. Mirashvili, M. S. Zainulina, S. A. Selkov, D. I. Sokolov
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	endothelial cells adhesion molecules placenta pre-eclampsia. Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/06ba384e3f8345c3beb72426c3be9d4b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:06ba384e3f8345c3beb72426c3be9d4b
record_format	dspace
spelling	oai:doaj.org-article:06ba384e3f8345c3beb72426c3be9d4b2021-11-18T08:03:42ZINFLUENCE OF SOLUBLE PLACENTAL TISSUE-DERIVED MOLECULES UPON EXPRESSION OF ADHESION MOLECULES BY EA.HY926 ENDOTHELIAL CELLS1563-06252313-741X10.15789/1563-0625-2011-6-589-596https://doaj.org/article/06ba384e3f8345c3beb72426c3be9d4b2014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/608https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. Leukocyte recruitment to placental tissue is an important factor of its development. In this respect, adhesion molecules at the endothelial cell surface represent a key determining factor of leukocyte adhesion and their trans-endothelial migration. The goal of investigation was to evaluate changed expression of adhesion molecules on the endothelial cells induced by supernates of placental tissue cultures. Placental tissue supernatants produced by the first- and third-trimester placental tissue from normal pregnancy, as well as from women with gestosis, induced higher expression of CD31, CD9, CD62E, CD62P, CD34, CD54, CD51/61, CD49d and integrin β7 expression by endothelial cells, as compared with their baseline levels. However, the supernates from pre-eclamptic placental tissue (3rd trimester) caused an increased CD9 expression by endothelial cells, as compared with effects of placental supernates from eclampsia-free cases. Our data contribute to understanding a possible role of endothelial cell adhesion molecules in recruitment of leukocytes to placental tissue and possible participation of adhesion molecules in pathogenesis of pre-eclampsia. The work was supported by a grant from Russian Ministry of Education and Science ГК №02.740.11.0711 and Presidential grant № НШ-3594.2010.7 and МД-150.2011.7. (Med. Immunol., 2011, vol. 13, N 6, pp 589-596)O. I. StepanovaT. U. LvovaE. N. PurbeevaM. I. MirashviliM. S. ZainulinaS. A. SelkovD. I. SokolovSPb RAACIarticleendothelial cellsadhesion moleculesplacentapre-eclampsia.Immunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 13, Iss 6, Pp 589-596 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	endothelial cells adhesion molecules placenta pre-eclampsia. Immunologic diseases. Allergy RC581-607
spellingShingle	endothelial cells adhesion molecules placenta pre-eclampsia. Immunologic diseases. Allergy RC581-607 O. I. Stepanova T. U. Lvova E. N. Purbeeva M. I. Mirashvili M. S. Zainulina S. A. Selkov D. I. Sokolov INFLUENCE OF SOLUBLE PLACENTAL TISSUE-DERIVED MOLECULES UPON EXPRESSION OF ADHESION MOLECULES BY EA.HY926 ENDOTHELIAL CELLS
description	Abstract. Leukocyte recruitment to placental tissue is an important factor of its development. In this respect, adhesion molecules at the endothelial cell surface represent a key determining factor of leukocyte adhesion and their trans-endothelial migration. The goal of investigation was to evaluate changed expression of adhesion molecules on the endothelial cells induced by supernates of placental tissue cultures. Placental tissue supernatants produced by the first- and third-trimester placental tissue from normal pregnancy, as well as from women with gestosis, induced higher expression of CD31, CD9, CD62E, CD62P, CD34, CD54, CD51/61, CD49d and integrin β7 expression by endothelial cells, as compared with their baseline levels. However, the supernates from pre-eclamptic placental tissue (3rd trimester) caused an increased CD9 expression by endothelial cells, as compared with effects of placental supernates from eclampsia-free cases. Our data contribute to understanding a possible role of endothelial cell adhesion molecules in recruitment of leukocytes to placental tissue and possible participation of adhesion molecules in pathogenesis of pre-eclampsia. The work was supported by a grant from Russian Ministry of Education and Science ГК №02.740.11.0711 and Presidential grant № НШ-3594.2010.7 and МД-150.2011.7. (Med. Immunol., 2011, vol. 13, N 6, pp 589-596)
format	article
author	O. I. Stepanova T. U. Lvova E. N. Purbeeva M. I. Mirashvili M. S. Zainulina S. A. Selkov D. I. Sokolov
author_facet	O. I. Stepanova T. U. Lvova E. N. Purbeeva M. I. Mirashvili M. S. Zainulina S. A. Selkov D. I. Sokolov
author_sort	O. I. Stepanova
title	INFLUENCE OF SOLUBLE PLACENTAL TISSUE-DERIVED MOLECULES UPON EXPRESSION OF ADHESION MOLECULES BY EA.HY926 ENDOTHELIAL CELLS
title_short	INFLUENCE OF SOLUBLE PLACENTAL TISSUE-DERIVED MOLECULES UPON EXPRESSION OF ADHESION MOLECULES BY EA.HY926 ENDOTHELIAL CELLS
title_full	INFLUENCE OF SOLUBLE PLACENTAL TISSUE-DERIVED MOLECULES UPON EXPRESSION OF ADHESION MOLECULES BY EA.HY926 ENDOTHELIAL CELLS
title_fullStr	INFLUENCE OF SOLUBLE PLACENTAL TISSUE-DERIVED MOLECULES UPON EXPRESSION OF ADHESION MOLECULES BY EA.HY926 ENDOTHELIAL CELLS
title_full_unstemmed	INFLUENCE OF SOLUBLE PLACENTAL TISSUE-DERIVED MOLECULES UPON EXPRESSION OF ADHESION MOLECULES BY EA.HY926 ENDOTHELIAL CELLS
title_sort	influence of soluble placental tissue-derived molecules upon expression of adhesion molecules by ea.hy926 endothelial cells
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/06ba384e3f8345c3beb72426c3be9d4b
work_keys_str_mv	AT oistepanova influenceofsolubleplacentaltissuederivedmoleculesuponexpressionofadhesionmoleculesbyeahy926endothelialcells AT tulvova influenceofsolubleplacentaltissuederivedmoleculesuponexpressionofadhesionmoleculesbyeahy926endothelialcells AT enpurbeeva influenceofsolubleplacentaltissuederivedmoleculesuponexpressionofadhesionmoleculesbyeahy926endothelialcells AT mimirashvili influenceofsolubleplacentaltissuederivedmoleculesuponexpressionofadhesionmoleculesbyeahy926endothelialcells AT mszainulina influenceofsolubleplacentaltissuederivedmoleculesuponexpressionofadhesionmoleculesbyeahy926endothelialcells AT saselkov influenceofsolubleplacentaltissuederivedmoleculesuponexpressionofadhesionmoleculesbyeahy926endothelialcells AT disokolov influenceofsolubleplacentaltissuederivedmoleculesuponexpressionofadhesionmoleculesbyeahy926endothelialcells
_version_	1718422461045800960

INFLUENCE OF SOLUBLE PLACENTAL TISSUE-DERIVED MOLECULES UPON EXPRESSION OF ADHESION MOLECULES BY EA.HY926 ENDOTHELIAL CELLS

Ejemplares similares