Melatonin administration provokes the activity of dendritic reticular cells in the seminal vesicle of Soay ram during the non-breeding season

Abstract Dendritic cells (DCs) are innate immune cells which engulf, process and present antigens to the naïve T-lymphocyte cells. However, little is known about the effect of melatonin on the DCs. The present study aimed to investigate the morphology and distribution of the DCs by transmission elec...

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Autores principales:	Hanan H. Abd-Elhafeez, A. H. S. Hassan, Manal T. Hussein
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/06bb4579323944f992b72b2753510e10
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spelling	oai:doaj.org-article:06bb4579323944f992b72b2753510e102021-12-02T14:12:08ZMelatonin administration provokes the activity of dendritic reticular cells in the seminal vesicle of Soay ram during the non-breeding season10.1038/s41598-020-79529-y2045-2322https://doaj.org/article/06bb4579323944f992b72b2753510e102021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79529-yhttps://doaj.org/toc/2045-2322Abstract Dendritic cells (DCs) are innate immune cells which engulf, process and present antigens to the naïve T-lymphocyte cells. However, little is known about the effect of melatonin on the DCs. The present study aimed to investigate the morphology and distribution of the DCs by transmission electron microscopy and Immunohistochemistry after melatonin administration. A total of 8 out of 15 adult ram was randomly selected to receive the melatonin implant and the remaining 7 animals received melatonin free implants. DCs showed positive immunoreactivity for CD117, S-100 protein and CD34. There is an obvious increase in the number of the positive immunoreactive cells to CD3, estrogen receptor alpha and progesterone in the treated groups. The expression of CD56 and MHCII in the DCs was abundant in the treated groups. The ultrastructure study revealed that melatonin exerts a stimulatory effect on the DCs which was associated with increment in the secretory activity of DCs. The secretory activity demarcated by an obvious increase in the number of mitochondria, cisternae of rER and a well-developed Golgi apparatus. The endosomal- lysosomal system was more developed in the treated groups. A rod-shaped Birbeck granule was demonstrated in the cytoplasm of the melatonin treated group. DCs were observed in a close contact to telocytes, T-Lymphocytes, nerve fibers and blood vessels. Taken together, melatonin administration elicits a stimulatory action on the DCs and macrophages through increasing the size, the number and the endosomal compartments which may correlate to increased immunity.Hanan H. Abd-ElhafeezA. H. S. HassanManal T. HusseinNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-20 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hanan H. Abd-Elhafeez A. H. S. Hassan Manal T. Hussein Melatonin administration provokes the activity of dendritic reticular cells in the seminal vesicle of Soay ram during the non-breeding season
description	Abstract Dendritic cells (DCs) are innate immune cells which engulf, process and present antigens to the naïve T-lymphocyte cells. However, little is known about the effect of melatonin on the DCs. The present study aimed to investigate the morphology and distribution of the DCs by transmission electron microscopy and Immunohistochemistry after melatonin administration. A total of 8 out of 15 adult ram was randomly selected to receive the melatonin implant and the remaining 7 animals received melatonin free implants. DCs showed positive immunoreactivity for CD117, S-100 protein and CD34. There is an obvious increase in the number of the positive immunoreactive cells to CD3, estrogen receptor alpha and progesterone in the treated groups. The expression of CD56 and MHCII in the DCs was abundant in the treated groups. The ultrastructure study revealed that melatonin exerts a stimulatory effect on the DCs which was associated with increment in the secretory activity of DCs. The secretory activity demarcated by an obvious increase in the number of mitochondria, cisternae of rER and a well-developed Golgi apparatus. The endosomal- lysosomal system was more developed in the treated groups. A rod-shaped Birbeck granule was demonstrated in the cytoplasm of the melatonin treated group. DCs were observed in a close contact to telocytes, T-Lymphocytes, nerve fibers and blood vessels. Taken together, melatonin administration elicits a stimulatory action on the DCs and macrophages through increasing the size, the number and the endosomal compartments which may correlate to increased immunity.
format	article
author	Hanan H. Abd-Elhafeez A. H. S. Hassan Manal T. Hussein
author_facet	Hanan H. Abd-Elhafeez A. H. S. Hassan Manal T. Hussein
author_sort	Hanan H. Abd-Elhafeez
title	Melatonin administration provokes the activity of dendritic reticular cells in the seminal vesicle of Soay ram during the non-breeding season
title_short	Melatonin administration provokes the activity of dendritic reticular cells in the seminal vesicle of Soay ram during the non-breeding season
title_full	Melatonin administration provokes the activity of dendritic reticular cells in the seminal vesicle of Soay ram during the non-breeding season
title_fullStr	Melatonin administration provokes the activity of dendritic reticular cells in the seminal vesicle of Soay ram during the non-breeding season
title_full_unstemmed	Melatonin administration provokes the activity of dendritic reticular cells in the seminal vesicle of Soay ram during the non-breeding season
title_sort	melatonin administration provokes the activity of dendritic reticular cells in the seminal vesicle of soay ram during the non-breeding season
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/06bb4579323944f992b72b2753510e10
work_keys_str_mv	AT hananhabdelhafeez melatoninadministrationprovokestheactivityofdendriticreticularcellsintheseminalvesicleofsoayramduringthenonbreedingseason AT ahshassan melatoninadministrationprovokestheactivityofdendriticreticularcellsintheseminalvesicleofsoayramduringthenonbreedingseason AT manalthussein melatoninadministrationprovokestheactivityofdendriticreticularcellsintheseminalvesicleofsoayramduringthenonbreedingseason
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Melatonin administration provokes the activity of dendritic reticular cells in the seminal vesicle of Soay ram during the non-breeding season

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