An electrodiffusive neuron-extracellular-glia model for exploring the genesis of slow potentials in the brain.

Within the computational neuroscience community, there has been a focus on simulating the electrical activity of neurons, while other components of brain tissue, such as glia cells and the extracellular space, are often neglected. Standard models of extracellular potentials are based on a combinatio...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Marte J Sætra, Gaute T Einevoll, Geir Halnes
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/06bc16df98964e27815f58a620dca192
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:06bc16df98964e27815f58a620dca192
record_format	dspace
spelling	oai:doaj.org-article:06bc16df98964e27815f58a620dca1922021-12-02T19:57:31ZAn electrodiffusive neuron-extracellular-glia model for exploring the genesis of slow potentials in the brain.1553-734X1553-735810.1371/journal.pcbi.1008143https://doaj.org/article/06bc16df98964e27815f58a620dca1922021-07-01T00:00:00Zhttps://doi.org/10.1371/journal.pcbi.1008143https://doaj.org/toc/1553-734Xhttps://doaj.org/toc/1553-7358Within the computational neuroscience community, there has been a focus on simulating the electrical activity of neurons, while other components of brain tissue, such as glia cells and the extracellular space, are often neglected. Standard models of extracellular potentials are based on a combination of multicompartmental models describing neural electrodynamics and volume conductor theory. Such models cannot be used to simulate the slow components of extracellular potentials, which depend on ion concentration dynamics, and the effect that this has on extracellular diffusion potentials and glial buffering currents. We here present the electrodiffusive neuron-extracellular-glia (edNEG) model, which we believe is the first model to combine compartmental neuron modeling with an electrodiffusive framework for intra- and extracellular ion concentration dynamics in a local piece of neuro-glial brain tissue. The edNEG model (i) keeps track of all intraneuronal, intraglial, and extracellular ion concentrations and electrical potentials, (ii) accounts for action potentials and dendritic calcium spikes in neurons, (iii) contains a neuronal and glial homeostatic machinery that gives physiologically realistic ion concentration dynamics, (iv) accounts for electrodiffusive transmembrane, intracellular, and extracellular ionic movements, and (v) accounts for glial and neuronal swelling caused by osmotic transmembrane pressure gradients. The edNEG model accounts for the concentration-dependent effects on ECS potentials that the standard models neglect. Using the edNEG model, we analyze these effects by splitting the extracellular potential into three components: one due to neural sink/source configurations, one due to glial sink/source configurations, and one due to extracellular diffusive currents. Through a series of simulations, we analyze the roles played by the various components and how they interact in generating the total slow potential. We conclude that the three components are of comparable magnitude and that the stimulus conditions determine which of the components that dominate.Marte J SætraGaute T EinevollGeir HalnesPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Computational Biology, Vol 17, Iss 7, p e1008143 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Marte J Sætra Gaute T Einevoll Geir Halnes An electrodiffusive neuron-extracellular-glia model for exploring the genesis of slow potentials in the brain.
description	Within the computational neuroscience community, there has been a focus on simulating the electrical activity of neurons, while other components of brain tissue, such as glia cells and the extracellular space, are often neglected. Standard models of extracellular potentials are based on a combination of multicompartmental models describing neural electrodynamics and volume conductor theory. Such models cannot be used to simulate the slow components of extracellular potentials, which depend on ion concentration dynamics, and the effect that this has on extracellular diffusion potentials and glial buffering currents. We here present the electrodiffusive neuron-extracellular-glia (edNEG) model, which we believe is the first model to combine compartmental neuron modeling with an electrodiffusive framework for intra- and extracellular ion concentration dynamics in a local piece of neuro-glial brain tissue. The edNEG model (i) keeps track of all intraneuronal, intraglial, and extracellular ion concentrations and electrical potentials, (ii) accounts for action potentials and dendritic calcium spikes in neurons, (iii) contains a neuronal and glial homeostatic machinery that gives physiologically realistic ion concentration dynamics, (iv) accounts for electrodiffusive transmembrane, intracellular, and extracellular ionic movements, and (v) accounts for glial and neuronal swelling caused by osmotic transmembrane pressure gradients. The edNEG model accounts for the concentration-dependent effects on ECS potentials that the standard models neglect. Using the edNEG model, we analyze these effects by splitting the extracellular potential into three components: one due to neural sink/source configurations, one due to glial sink/source configurations, and one due to extracellular diffusive currents. Through a series of simulations, we analyze the roles played by the various components and how they interact in generating the total slow potential. We conclude that the three components are of comparable magnitude and that the stimulus conditions determine which of the components that dominate.
format	article
author	Marte J Sætra Gaute T Einevoll Geir Halnes
author_facet	Marte J Sætra Gaute T Einevoll Geir Halnes
author_sort	Marte J Sætra
title	An electrodiffusive neuron-extracellular-glia model for exploring the genesis of slow potentials in the brain.
title_short	An electrodiffusive neuron-extracellular-glia model for exploring the genesis of slow potentials in the brain.
title_full	An electrodiffusive neuron-extracellular-glia model for exploring the genesis of slow potentials in the brain.
title_fullStr	An electrodiffusive neuron-extracellular-glia model for exploring the genesis of slow potentials in the brain.
title_full_unstemmed	An electrodiffusive neuron-extracellular-glia model for exploring the genesis of slow potentials in the brain.
title_sort	electrodiffusive neuron-extracellular-glia model for exploring the genesis of slow potentials in the brain.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/06bc16df98964e27815f58a620dca192
work_keys_str_mv	AT martejsætra anelectrodiffusiveneuronextracellulargliamodelforexploringthegenesisofslowpotentialsinthebrain AT gauteteinevoll anelectrodiffusiveneuronextracellulargliamodelforexploringthegenesisofslowpotentialsinthebrain AT geirhalnes anelectrodiffusiveneuronextracellulargliamodelforexploringthegenesisofslowpotentialsinthebrain AT martejsætra electrodiffusiveneuronextracellulargliamodelforexploringthegenesisofslowpotentialsinthebrain AT gauteteinevoll electrodiffusiveneuronextracellulargliamodelforexploringthegenesisofslowpotentialsinthebrain AT geirhalnes electrodiffusiveneuronextracellulargliamodelforexploringthegenesisofslowpotentialsinthebrain
_version_	1718375821852278784

An electrodiffusive neuron-extracellular-glia model for exploring the genesis of slow potentials in the brain.

Ejemplares similares