Usefulness of matrix metalloproteinase-7 in saliva as a diagnostic biomarker for laryngopharyngeal reflux disease

Abstract Several diagnostic methods are currently being used to diagnose LPRD (laryngopharyngeal reflux disease), but have the disadvantage of being invasive, subjective, or expensive. Our purpose in this study was to investigate the correlation between pepsin and MMP-7 (Matrix Metalloproteinase-7)...

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Autores principales:	Nu-Ri Im, Byoungjae Kim, Kwang-Yoon Jung, Seung-Kuk Baek
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/06bd5adca70c456aacaf113289bca550
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spelling	oai:doaj.org-article:06bd5adca70c456aacaf113289bca5502021-12-02T19:02:37ZUsefulness of matrix metalloproteinase-7 in saliva as a diagnostic biomarker for laryngopharyngeal reflux disease10.1038/s41598-021-96554-72045-2322https://doaj.org/article/06bd5adca70c456aacaf113289bca5502021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96554-7https://doaj.org/toc/2045-2322Abstract Several diagnostic methods are currently being used to diagnose LPRD (laryngopharyngeal reflux disease), but have the disadvantage of being invasive, subjective, or expensive. Our purpose in this study was to investigate the correlation between pepsin and MMP-7 (Matrix Metalloproteinase-7) in pharyngeal secretions of subjects according to RSI (Reflux Symptom Index) score to find out the diagnostic value of MMP-7. We recruited 173 subjects aged between 19 and 85 years who completed the RSI scale. All samples were taken after waking up, and the amount of the pepsin and MMP-7 in saliva were measured by means of an enzyme activity assay. There was a significant increase of pepsin and MMP-7 activity in the study group with an RSI score of 13 or higher. The sensitivity and specificity of MMP-7 for predicting the possibility of an RSI of 13 or more was higher than that of pepsin. When MMP-7 and pepsin were combined, this sensitivity and specificity increased. An enzyme assay of MMP-7 in saliva may be a noninvasive and easy technique for diagnosing LPRD.Nu-Ri ImByoungjae KimKwang-Yoon JungSeung-Kuk BaekNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Nu-Ri Im Byoungjae Kim Kwang-Yoon Jung Seung-Kuk Baek Usefulness of matrix metalloproteinase-7 in saliva as a diagnostic biomarker for laryngopharyngeal reflux disease
description	Abstract Several diagnostic methods are currently being used to diagnose LPRD (laryngopharyngeal reflux disease), but have the disadvantage of being invasive, subjective, or expensive. Our purpose in this study was to investigate the correlation between pepsin and MMP-7 (Matrix Metalloproteinase-7) in pharyngeal secretions of subjects according to RSI (Reflux Symptom Index) score to find out the diagnostic value of MMP-7. We recruited 173 subjects aged between 19 and 85 years who completed the RSI scale. All samples were taken after waking up, and the amount of the pepsin and MMP-7 in saliva were measured by means of an enzyme activity assay. There was a significant increase of pepsin and MMP-7 activity in the study group with an RSI score of 13 or higher. The sensitivity and specificity of MMP-7 for predicting the possibility of an RSI of 13 or more was higher than that of pepsin. When MMP-7 and pepsin were combined, this sensitivity and specificity increased. An enzyme assay of MMP-7 in saliva may be a noninvasive and easy technique for diagnosing LPRD.
format	article
author	Nu-Ri Im Byoungjae Kim Kwang-Yoon Jung Seung-Kuk Baek
author_facet	Nu-Ri Im Byoungjae Kim Kwang-Yoon Jung Seung-Kuk Baek
author_sort	Nu-Ri Im
title	Usefulness of matrix metalloproteinase-7 in saliva as a diagnostic biomarker for laryngopharyngeal reflux disease
title_short	Usefulness of matrix metalloproteinase-7 in saliva as a diagnostic biomarker for laryngopharyngeal reflux disease
title_full	Usefulness of matrix metalloproteinase-7 in saliva as a diagnostic biomarker for laryngopharyngeal reflux disease
title_fullStr	Usefulness of matrix metalloproteinase-7 in saliva as a diagnostic biomarker for laryngopharyngeal reflux disease
title_full_unstemmed	Usefulness of matrix metalloproteinase-7 in saliva as a diagnostic biomarker for laryngopharyngeal reflux disease
title_sort	usefulness of matrix metalloproteinase-7 in saliva as a diagnostic biomarker for laryngopharyngeal reflux disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/06bd5adca70c456aacaf113289bca550
work_keys_str_mv	AT nuriim usefulnessofmatrixmetalloproteinase7insalivaasadiagnosticbiomarkerforlaryngopharyngealrefluxdisease AT byoungjaekim usefulnessofmatrixmetalloproteinase7insalivaasadiagnosticbiomarkerforlaryngopharyngealrefluxdisease AT kwangyoonjung usefulnessofmatrixmetalloproteinase7insalivaasadiagnosticbiomarkerforlaryngopharyngealrefluxdisease AT seungkukbaek usefulnessofmatrixmetalloproteinase7insalivaasadiagnosticbiomarkerforlaryngopharyngealrefluxdisease
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Usefulness of matrix metalloproteinase-7 in saliva as a diagnostic biomarker for laryngopharyngeal reflux disease

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