Evaluation of the Healing Effect of Ointments Based on Bee Products on Cutaneous Lesions in Wistar Rats

The wound-healing capacity of ointments based on bee products was investigated in vivo on three experimental models of incision, excision and heat burn. For this purpose, four ointments were prepared with propolis, honey, apilarnil (drone brood homogenate) and a mixture of these three apitherapy pro...

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Autores principales:	Calin Vasile Andritoiu, Cristina Lungu, Maricel Danu, Bianca Ivanescu, Corina Elena Andriescu, Laurian Vlase, Corneliu Havarneanu, Camelia Elena Iurciuc (Tincu), Marcel Popa
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	bee products honey propolis apilarnil wound healing rheological characterization Medicine R Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/06bf10a31c804162ad734ec7c2e58f2f
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id	oai:doaj.org-article:06bf10a31c804162ad734ec7c2e58f2f
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spelling	oai:doaj.org-article:06bf10a31c804162ad734ec7c2e58f2f2021-11-25T18:39:42ZEvaluation of the Healing Effect of Ointments Based on Bee Products on Cutaneous Lesions in Wistar Rats10.3390/ph141111461424-8247https://doaj.org/article/06bf10a31c804162ad734ec7c2e58f2f2021-11-01T00:00:00Zhttps://www.mdpi.com/1424-8247/14/11/1146https://doaj.org/toc/1424-8247The wound-healing capacity of ointments based on bee products was investigated in vivo on three experimental models of incision, excision and heat burn. For this purpose, four ointments were prepared with propolis, honey, apilarnil (drone brood homogenate) and a mixture of these three apitherapy products. The ointments were applied topically for 21 days. Clinical and macroscopic evaluation was performed throughout the experiment, with the recording of the re-epithelialization period and determination of the wound contraction rate on days 6 and 9. The histopathological examination was performed on days 1, 3, 12 and 21 of the treatment. The topical formulations were also characterized from a rheological point of view in order to verify their stability. HPLC analysis of propolis revealed the presence of phenolic compounds, particularly ferulic acid and p-coumaric which were found in high amounts. All ointments had beneficial effects on wound contraction and the re-epithelialization period, but the most significant result, both macroscopically and especially in terms of histological architecture, was presented by the ointment that contains all three apitherapy products, due to their synergistic effect.Calin Vasile AndritoiuCristina LunguMaricel DanuBianca IvanescuCorina Elena AndriescuLaurian VlaseCorneliu HavarneanuCamelia Elena Iurciuc (Tincu)Marcel PopaMDPI AGarticlebee productshoneypropolisapilarnilwound healingrheological characterizationMedicineRPharmacy and materia medicaRS1-441ENPharmaceuticals, Vol 14, Iss 1146, p 1146 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	bee products honey propolis apilarnil wound healing rheological characterization Medicine R Pharmacy and materia medica RS1-441
spellingShingle	bee products honey propolis apilarnil wound healing rheological characterization Medicine R Pharmacy and materia medica RS1-441 Calin Vasile Andritoiu Cristina Lungu Maricel Danu Bianca Ivanescu Corina Elena Andriescu Laurian Vlase Corneliu Havarneanu Camelia Elena Iurciuc (Tincu) Marcel Popa Evaluation of the Healing Effect of Ointments Based on Bee Products on Cutaneous Lesions in Wistar Rats
description	The wound-healing capacity of ointments based on bee products was investigated in vivo on three experimental models of incision, excision and heat burn. For this purpose, four ointments were prepared with propolis, honey, apilarnil (drone brood homogenate) and a mixture of these three apitherapy products. The ointments were applied topically for 21 days. Clinical and macroscopic evaluation was performed throughout the experiment, with the recording of the re-epithelialization period and determination of the wound contraction rate on days 6 and 9. The histopathological examination was performed on days 1, 3, 12 and 21 of the treatment. The topical formulations were also characterized from a rheological point of view in order to verify their stability. HPLC analysis of propolis revealed the presence of phenolic compounds, particularly ferulic acid and p-coumaric which were found in high amounts. All ointments had beneficial effects on wound contraction and the re-epithelialization period, but the most significant result, both macroscopically and especially in terms of histological architecture, was presented by the ointment that contains all three apitherapy products, due to their synergistic effect.
format	article
author	Calin Vasile Andritoiu Cristina Lungu Maricel Danu Bianca Ivanescu Corina Elena Andriescu Laurian Vlase Corneliu Havarneanu Camelia Elena Iurciuc (Tincu) Marcel Popa
author_facet	Calin Vasile Andritoiu Cristina Lungu Maricel Danu Bianca Ivanescu Corina Elena Andriescu Laurian Vlase Corneliu Havarneanu Camelia Elena Iurciuc (Tincu) Marcel Popa
author_sort	Calin Vasile Andritoiu
title	Evaluation of the Healing Effect of Ointments Based on Bee Products on Cutaneous Lesions in Wistar Rats
title_short	Evaluation of the Healing Effect of Ointments Based on Bee Products on Cutaneous Lesions in Wistar Rats
title_full	Evaluation of the Healing Effect of Ointments Based on Bee Products on Cutaneous Lesions in Wistar Rats
title_fullStr	Evaluation of the Healing Effect of Ointments Based on Bee Products on Cutaneous Lesions in Wistar Rats
title_full_unstemmed	Evaluation of the Healing Effect of Ointments Based on Bee Products on Cutaneous Lesions in Wistar Rats
title_sort	evaluation of the healing effect of ointments based on bee products on cutaneous lesions in wistar rats
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/06bf10a31c804162ad734ec7c2e58f2f
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Evaluation of the Healing Effect of Ointments Based on Bee Products on Cutaneous Lesions in Wistar Rats

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