Direct cell–cell contact between mature osteoblasts and osteoclasts dynamically controls their functions in vivo

Direct cell–cell contact between mature osteoblasts and osteoclasts dynamically controls their functions in vivo

Communication between osteoblasts and osteoclasts is essential for bone homeostasis, but the mode of interaction is unclear. The authors use intravital two-photon microscopy in mice to show that these cells directly interact, regulating activity of osteoclasts, and that the interaction is modulated...

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Autores principales: Masayuki Furuya, Junichi Kikuta, Sayumi Fujimori, Shigeto Seno, Hiroki Maeda, Mai Shirazaki, Maki Uenaka, Hiroki Mizuno, Yoriko Iwamoto, Akito Morimoto, Kunihiko Hashimoto, Takeshi Ito, Yukihiro Isogai, Masafumi Kashii, Takashi Kaito, Shinsuke Ohba, Ung-il Chung, Alexander C. Lichtler, Kazuya Kikuchi, Hideo Matsuda, Hideki Yoshikawa, Masaru Ishii
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/06c00b6672ba4168b243c12ea9e27007
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spelling oai:doaj.org-article:06c00b6672ba4168b243c12ea9e270072021-12-02T16:50:12ZDirect cell–cell contact between mature osteoblasts and osteoclasts dynamically controls their functions in vivo10.1038/s41467-017-02541-w2041-1723https://doaj.org/article/06c00b6672ba4168b243c12ea9e270072018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02541-whttps://doaj.org/toc/2041-1723Communication between osteoblasts and osteoclasts is essential for bone homeostasis, but the mode of interaction is unclear. The authors use intravital two-photon microscopy in mice to show that these cells directly interact, regulating activity of osteoclasts, and that the interaction is modulated by parathyroid hormone administration.Masayuki FuruyaJunichi KikutaSayumi FujimoriShigeto SenoHiroki MaedaMai ShirazakiMaki UenakaHiroki MizunoYoriko IwamotoAkito MorimotoKunihiko HashimotoTakeshi ItoYukihiro IsogaiMasafumi KashiiTakashi KaitoShinsuke OhbaUng-il ChungAlexander C. LichtlerKazuya KikuchiHideo MatsudaHideki YoshikawaMasaru IshiiNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Masayuki Furuya
Junichi Kikuta
Sayumi Fujimori
Shigeto Seno
Hiroki Maeda
Mai Shirazaki
Maki Uenaka
Hiroki Mizuno
Yoriko Iwamoto
Akito Morimoto
Kunihiko Hashimoto
Takeshi Ito
Yukihiro Isogai
Masafumi Kashii
Takashi Kaito
Shinsuke Ohba
Ung-il Chung
Alexander C. Lichtler
Kazuya Kikuchi
Hideo Matsuda
Hideki Yoshikawa
Masaru Ishii
Direct cell–cell contact between mature osteoblasts and osteoclasts dynamically controls their functions in vivo
description Communication between osteoblasts and osteoclasts is essential for bone homeostasis, but the mode of interaction is unclear. The authors use intravital two-photon microscopy in mice to show that these cells directly interact, regulating activity of osteoclasts, and that the interaction is modulated by parathyroid hormone administration.
format article
author Masayuki Furuya
Junichi Kikuta
Sayumi Fujimori
Shigeto Seno
Hiroki Maeda
Mai Shirazaki
Maki Uenaka
Hiroki Mizuno
Yoriko Iwamoto
Akito Morimoto
Kunihiko Hashimoto
Takeshi Ito
Yukihiro Isogai
Masafumi Kashii
Takashi Kaito
Shinsuke Ohba
Ung-il Chung
Alexander C. Lichtler
Kazuya Kikuchi
Hideo Matsuda
Hideki Yoshikawa
Masaru Ishii
author_facet Masayuki Furuya
Junichi Kikuta
Sayumi Fujimori
Shigeto Seno
Hiroki Maeda
Mai Shirazaki
Maki Uenaka
Hiroki Mizuno
Yoriko Iwamoto
Akito Morimoto
Kunihiko Hashimoto
Takeshi Ito
Yukihiro Isogai
Masafumi Kashii
Takashi Kaito
Shinsuke Ohba
Ung-il Chung
Alexander C. Lichtler
Kazuya Kikuchi
Hideo Matsuda
Hideki Yoshikawa
Masaru Ishii
author_sort Masayuki Furuya
title Direct cell–cell contact between mature osteoblasts and osteoclasts dynamically controls their functions in vivo
title_short Direct cell–cell contact between mature osteoblasts and osteoclasts dynamically controls their functions in vivo
title_full Direct cell–cell contact between mature osteoblasts and osteoclasts dynamically controls their functions in vivo
title_fullStr Direct cell–cell contact between mature osteoblasts and osteoclasts dynamically controls their functions in vivo
title_full_unstemmed Direct cell–cell contact between mature osteoblasts and osteoclasts dynamically controls their functions in vivo
title_sort direct cell–cell contact between mature osteoblasts and osteoclasts dynamically controls their functions in vivo
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/06c00b6672ba4168b243c12ea9e27007
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