Suppressor mutations in Rpf2–Rrs1 or Rpl5 bypass the Cgr1 function for pre-ribosomal 5S RNP-rotation

During biogenesis of the eukaryotic 60S ribosome, a large rotational movement of the 5S RNP is required to achieve its mature position. By analyzing extragenic suppressors of crg1—a key factor required for rotation—the authors provide mechanistic insight into a key step of ribosome biogenesis.

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Autores principales:	Matthias Thoms, Valentin Mitterer, Lukas Kater, Laurent Falquet, Roland Beckmann, Dieter Kressler, Ed Hurt
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/06c0d4db88e6438d990c14cbd54c9606
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spelling	oai:doaj.org-article:06c0d4db88e6438d990c14cbd54c96062021-12-02T14:39:44ZSuppressor mutations in Rpf2–Rrs1 or Rpl5 bypass the Cgr1 function for pre-ribosomal 5S RNP-rotation10.1038/s41467-018-06660-w2041-1723https://doaj.org/article/06c0d4db88e6438d990c14cbd54c96062018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06660-whttps://doaj.org/toc/2041-1723During biogenesis of the eukaryotic 60S ribosome, a large rotational movement of the 5S RNP is required to achieve its mature position. By analyzing extragenic suppressors of crg1—a key factor required for rotation—the authors provide mechanistic insight into a key step of ribosome biogenesis.Matthias ThomsValentin MittererLukas KaterLaurent FalquetRoland BeckmannDieter KresslerEd HurtNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Matthias Thoms Valentin Mitterer Lukas Kater Laurent Falquet Roland Beckmann Dieter Kressler Ed Hurt Suppressor mutations in Rpf2–Rrs1 or Rpl5 bypass the Cgr1 function for pre-ribosomal 5S RNP-rotation
description	During biogenesis of the eukaryotic 60S ribosome, a large rotational movement of the 5S RNP is required to achieve its mature position. By analyzing extragenic suppressors of crg1—a key factor required for rotation—the authors provide mechanistic insight into a key step of ribosome biogenesis.
format	article
author	Matthias Thoms Valentin Mitterer Lukas Kater Laurent Falquet Roland Beckmann Dieter Kressler Ed Hurt
author_facet	Matthias Thoms Valentin Mitterer Lukas Kater Laurent Falquet Roland Beckmann Dieter Kressler Ed Hurt
author_sort	Matthias Thoms
title	Suppressor mutations in Rpf2–Rrs1 or Rpl5 bypass the Cgr1 function for pre-ribosomal 5S RNP-rotation
title_short	Suppressor mutations in Rpf2–Rrs1 or Rpl5 bypass the Cgr1 function for pre-ribosomal 5S RNP-rotation
title_full	Suppressor mutations in Rpf2–Rrs1 or Rpl5 bypass the Cgr1 function for pre-ribosomal 5S RNP-rotation
title_fullStr	Suppressor mutations in Rpf2–Rrs1 or Rpl5 bypass the Cgr1 function for pre-ribosomal 5S RNP-rotation
title_full_unstemmed	Suppressor mutations in Rpf2–Rrs1 or Rpl5 bypass the Cgr1 function for pre-ribosomal 5S RNP-rotation
title_sort	suppressor mutations in rpf2–rrs1 or rpl5 bypass the cgr1 function for pre-ribosomal 5s rnp-rotation
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/06c0d4db88e6438d990c14cbd54c9606
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Suppressor mutations in Rpf2–Rrs1 or Rpl5 bypass the Cgr1 function for pre-ribosomal 5S RNP-rotation

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