Association between butyrylcholinesterase K variant and mild cognitive impairment in the Thai community-dwelling patients

Natsalil Pongthanaracht,1 Somchai Yanarojana,1 Darawan Pinthong,1 Supeenun Unchern,1 Amnuay Thithapandha,1 Prasert Assantachai,2 Porntip Supavilai11Department of Pharmacology, Faculty of Science, 2Department of Preventive and Social Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University,...

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Autores principales:	Pongthanaracht N, Yanarojana S, Pinthong D, Unchern S, Thithapandha A, Assantachai P, Supavilai P
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	butyrylcholinesterase K-variant butyrylcholinesterase activity mild cognitive impairment Thai community-dwelling patients Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/06c0d9f69df74790a24140e2bec4e8b0
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spelling	oai:doaj.org-article:06c0d9f69df74790a24140e2bec4e8b02021-12-02T04:30:05ZAssociation between butyrylcholinesterase K variant and mild cognitive impairment in the Thai community-dwelling patients1178-1998https://doaj.org/article/06c0d9f69df74790a24140e2bec4e8b02017-05-01T00:00:00Zhttps://www.dovepress.com/association-between-butyrylcholinesterase-k-variant-and-mild-cognitive-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Natsalil Pongthanaracht,1 Somchai Yanarojana,1 Darawan Pinthong,1 Supeenun Unchern,1 Amnuay Thithapandha,1 Prasert Assantachai,2 Porntip Supavilai11Department of Pharmacology, Faculty of Science, 2Department of Preventive and Social Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, ThailandObjective: To study the association of the butyrylcholinesterase K variant (BChE-K) and the plasma BChE activity with mild cognitive impairment (MCI) in Thai community-dwelling patients.Methods: One hundred patients diagnosed with MCI and 100 control subjects were recruited from the community-dwelling setting in Bangkok, Thailand. The genotype and allele distributions of the BChE-K were determined by polymerase chain reaction and subsequent DNA sequencing. The BChE activity was measured in plasma according to the Ellman’s method.Results: The BChE-K allele frequencies in the Thai community-dwelling patients were in accordance with other ethnics. The BChE-K allele frequency in the control subjects (12%) was higher than that of MCI patients (5.5%), suggesting a protective role of BChE-K for MCI in the Thai community-dwelling patients. The BChE-K homozygotes were significantly associated with lower BChE activity.Conclusion: Our results suggested that the BChE-K may be implicated as a protective factor for MCI in the Thai community-dwelling patients, although a further study with a large sample size is warranted to confirm this.Keywords: butyrylcholinesterase K variant, butyrylcholinesterase activity, mild cognitive impairment, Thai community-dwelling patientsPongthanaracht NYanarojana SPinthong DUnchern SThithapandha AAssantachai PSupavilai PDove Medical Pressarticlebutyrylcholinesterase K-variantbutyrylcholinesterase activitymild cognitive impairmentThai community-dwelling patientsGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 12, Pp 897-901 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	butyrylcholinesterase K-variant butyrylcholinesterase activity mild cognitive impairment Thai community-dwelling patients Geriatrics RC952-954.6
spellingShingle	butyrylcholinesterase K-variant butyrylcholinesterase activity mild cognitive impairment Thai community-dwelling patients Geriatrics RC952-954.6 Pongthanaracht N Yanarojana S Pinthong D Unchern S Thithapandha A Assantachai P Supavilai P Association between butyrylcholinesterase K variant and mild cognitive impairment in the Thai community-dwelling patients
description	Natsalil Pongthanaracht,1 Somchai Yanarojana,1 Darawan Pinthong,1 Supeenun Unchern,1 Amnuay Thithapandha,1 Prasert Assantachai,2 Porntip Supavilai11Department of Pharmacology, Faculty of Science, 2Department of Preventive and Social Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, ThailandObjective: To study the association of the butyrylcholinesterase K variant (BChE-K) and the plasma BChE activity with mild cognitive impairment (MCI) in Thai community-dwelling patients.Methods: One hundred patients diagnosed with MCI and 100 control subjects were recruited from the community-dwelling setting in Bangkok, Thailand. The genotype and allele distributions of the BChE-K were determined by polymerase chain reaction and subsequent DNA sequencing. The BChE activity was measured in plasma according to the Ellman’s method.Results: The BChE-K allele frequencies in the Thai community-dwelling patients were in accordance with other ethnics. The BChE-K allele frequency in the control subjects (12%) was higher than that of MCI patients (5.5%), suggesting a protective role of BChE-K for MCI in the Thai community-dwelling patients. The BChE-K homozygotes were significantly associated with lower BChE activity.Conclusion: Our results suggested that the BChE-K may be implicated as a protective factor for MCI in the Thai community-dwelling patients, although a further study with a large sample size is warranted to confirm this.Keywords: butyrylcholinesterase K variant, butyrylcholinesterase activity, mild cognitive impairment, Thai community-dwelling patients
format	article
author	Pongthanaracht N Yanarojana S Pinthong D Unchern S Thithapandha A Assantachai P Supavilai P
author_facet	Pongthanaracht N Yanarojana S Pinthong D Unchern S Thithapandha A Assantachai P Supavilai P
author_sort	Pongthanaracht N
title	Association between butyrylcholinesterase K variant and mild cognitive impairment in the Thai community-dwelling patients
title_short	Association between butyrylcholinesterase K variant and mild cognitive impairment in the Thai community-dwelling patients
title_full	Association between butyrylcholinesterase K variant and mild cognitive impairment in the Thai community-dwelling patients
title_fullStr	Association between butyrylcholinesterase K variant and mild cognitive impairment in the Thai community-dwelling patients
title_full_unstemmed	Association between butyrylcholinesterase K variant and mild cognitive impairment in the Thai community-dwelling patients
title_sort	association between butyrylcholinesterase k variant and mild cognitive impairment in the thai community-dwelling patients
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/06c0d9f69df74790a24140e2bec4e8b0
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Association between butyrylcholinesterase K variant and mild cognitive impairment in the Thai community-dwelling patients

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