European ancestry predominates in neuromyelitis optica and multiple sclerosis patients from Brazil.
<h4>Background</h4>Neuromyelitis optica (NMO) is considered relatively more common in non-Whites, whereas multiple sclerosis (MS) presents a high prevalence rate, particularly in Whites from Western countries populations. However, no study has used ancestry informative markers (AIMs) to...
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2013
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oai:doaj.org-article:06c31fb1b57247c29572363ee00bc1df2021-11-18T07:52:42ZEuropean ancestry predominates in neuromyelitis optica and multiple sclerosis patients from Brazil.1932-620310.1371/journal.pone.0058925https://doaj.org/article/06c31fb1b57247c29572363ee00bc1df2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23527051/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Neuromyelitis optica (NMO) is considered relatively more common in non-Whites, whereas multiple sclerosis (MS) presents a high prevalence rate, particularly in Whites from Western countries populations. However, no study has used ancestry informative markers (AIMs) to estimate the genetic ancestry contribution to NMO patients.<h4>Methods</h4>Twelve AIMs were selected based on the large allele frequency differences among European, African, and Amerindian populations, in order to investigate the genetic contribution of each ancestral group in 236 patients with MS and NMO, diagnosed using the McDonald and Wingerchuck criteria, respectively. All 128 MS patients were recruited at the Faculty of Medicine of Ribeirão Preto (MS-RP), Southeastern Brazil, as well as 108 healthy bone marrow donors considered as healthy controls. A total of 108 NMO patients were recruited from five Neurology centers from different Brazilian regions, including Ribeirão Preto (NMO-RP).<h4>Principal findings</h4>European ancestry contribution was higher in MS-RP than in NMO-RP (78.5% vs. 68.7%) patients. In contrast, African ancestry estimates were higher in NMO-RP than in MS-RP (20.5% vs. 12.5%) patients. Moreover, principal component analyses showed that groups of NMO patients from different Brazilian regions were clustered close to the European ancestral population.<h4>Conclusions</h4>Our findings demonstrate that European genetic contribution predominates in NMO and MS patients from Brazil.Doralina Guimarães BrumMarcelo Rizzatti LuizonAntônio Carlos SantosMarco Aurélio Lana-PeixotoCristiane Franklin RochaMaria Lucia BritoEnedina Maria Lobato de OliveiraDenis Bernardi BichuettiAlberto Alan GabbaiDenise Sisterolli DinizDamacio Ramon Kaimen-MacielElizabeth Regina Comini-FrotaClaudia E Vieira WiezelYara Costa Netto MunizRoberta Martins da Silva CostaCelso Teixeira Mendes-JuniorEduardo Antônio DonadiAmilton Antunes BarreiraAguinaldo Luiz SimõesPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 3, p e58925 (2013) |
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Medicine R Science Q Doralina Guimarães Brum Marcelo Rizzatti Luizon Antônio Carlos Santos Marco Aurélio Lana-Peixoto Cristiane Franklin Rocha Maria Lucia Brito Enedina Maria Lobato de Oliveira Denis Bernardi Bichuetti Alberto Alan Gabbai Denise Sisterolli Diniz Damacio Ramon Kaimen-Maciel Elizabeth Regina Comini-Frota Claudia E Vieira Wiezel Yara Costa Netto Muniz Roberta Martins da Silva Costa Celso Teixeira Mendes-Junior Eduardo Antônio Donadi Amilton Antunes Barreira Aguinaldo Luiz Simões European ancestry predominates in neuromyelitis optica and multiple sclerosis patients from Brazil. |
| description |
<h4>Background</h4>Neuromyelitis optica (NMO) is considered relatively more common in non-Whites, whereas multiple sclerosis (MS) presents a high prevalence rate, particularly in Whites from Western countries populations. However, no study has used ancestry informative markers (AIMs) to estimate the genetic ancestry contribution to NMO patients.<h4>Methods</h4>Twelve AIMs were selected based on the large allele frequency differences among European, African, and Amerindian populations, in order to investigate the genetic contribution of each ancestral group in 236 patients with MS and NMO, diagnosed using the McDonald and Wingerchuck criteria, respectively. All 128 MS patients were recruited at the Faculty of Medicine of Ribeirão Preto (MS-RP), Southeastern Brazil, as well as 108 healthy bone marrow donors considered as healthy controls. A total of 108 NMO patients were recruited from five Neurology centers from different Brazilian regions, including Ribeirão Preto (NMO-RP).<h4>Principal findings</h4>European ancestry contribution was higher in MS-RP than in NMO-RP (78.5% vs. 68.7%) patients. In contrast, African ancestry estimates were higher in NMO-RP than in MS-RP (20.5% vs. 12.5%) patients. Moreover, principal component analyses showed that groups of NMO patients from different Brazilian regions were clustered close to the European ancestral population.<h4>Conclusions</h4>Our findings demonstrate that European genetic contribution predominates in NMO and MS patients from Brazil. |
| format |
article |
| author |
Doralina Guimarães Brum Marcelo Rizzatti Luizon Antônio Carlos Santos Marco Aurélio Lana-Peixoto Cristiane Franklin Rocha Maria Lucia Brito Enedina Maria Lobato de Oliveira Denis Bernardi Bichuetti Alberto Alan Gabbai Denise Sisterolli Diniz Damacio Ramon Kaimen-Maciel Elizabeth Regina Comini-Frota Claudia E Vieira Wiezel Yara Costa Netto Muniz Roberta Martins da Silva Costa Celso Teixeira Mendes-Junior Eduardo Antônio Donadi Amilton Antunes Barreira Aguinaldo Luiz Simões |
| author_facet |
Doralina Guimarães Brum Marcelo Rizzatti Luizon Antônio Carlos Santos Marco Aurélio Lana-Peixoto Cristiane Franklin Rocha Maria Lucia Brito Enedina Maria Lobato de Oliveira Denis Bernardi Bichuetti Alberto Alan Gabbai Denise Sisterolli Diniz Damacio Ramon Kaimen-Maciel Elizabeth Regina Comini-Frota Claudia E Vieira Wiezel Yara Costa Netto Muniz Roberta Martins da Silva Costa Celso Teixeira Mendes-Junior Eduardo Antônio Donadi Amilton Antunes Barreira Aguinaldo Luiz Simões |
| author_sort |
Doralina Guimarães Brum |
| title |
European ancestry predominates in neuromyelitis optica and multiple sclerosis patients from Brazil. |
| title_short |
European ancestry predominates in neuromyelitis optica and multiple sclerosis patients from Brazil. |
| title_full |
European ancestry predominates in neuromyelitis optica and multiple sclerosis patients from Brazil. |
| title_fullStr |
European ancestry predominates in neuromyelitis optica and multiple sclerosis patients from Brazil. |
| title_full_unstemmed |
European ancestry predominates in neuromyelitis optica and multiple sclerosis patients from Brazil. |
| title_sort |
european ancestry predominates in neuromyelitis optica and multiple sclerosis patients from brazil. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2013 |
| url |
https://doaj.org/article/06c31fb1b57247c29572363ee00bc1df |
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