Cryo-EM structure of catalytic ribonucleoprotein complex RNase MRP

Ribozyme-based RNase MRP is an essential eukaryotic enzyme involved in the maturation of rRNA and is evolutionarily related to RNase P. Here, the authors present the 3.0 Å cryo-EM structure of the S. cerevisiae RNase MRP holoenzyme, a 450 kDa ribonucleoprotein complex and compare it with RNase P....

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Autores principales: Anna Perederina, Di Li, Hyunwook Lee, Carol Bator, Igor Berezin, Susan L. Hafenstein, Andrey S. Krasilnikov
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/06c391967b3f4eb3af021d620c244d8d
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spelling oai:doaj.org-article:06c391967b3f4eb3af021d620c244d8d2021-12-02T18:34:08ZCryo-EM structure of catalytic ribonucleoprotein complex RNase MRP10.1038/s41467-020-17308-z2041-1723https://doaj.org/article/06c391967b3f4eb3af021d620c244d8d2020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17308-zhttps://doaj.org/toc/2041-1723Ribozyme-based RNase MRP is an essential eukaryotic enzyme involved in the maturation of rRNA and is evolutionarily related to RNase P. Here, the authors present the 3.0 Å cryo-EM structure of the S. cerevisiae RNase MRP holoenzyme, a 450 kDa ribonucleoprotein complex and compare it with RNase P.Anna PerederinaDi LiHyunwook LeeCarol BatorIgor BerezinSusan L. HafensteinAndrey S. KrasilnikovNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Anna Perederina
Di Li
Hyunwook Lee
Carol Bator
Igor Berezin
Susan L. Hafenstein
Andrey S. Krasilnikov
Cryo-EM structure of catalytic ribonucleoprotein complex RNase MRP
description Ribozyme-based RNase MRP is an essential eukaryotic enzyme involved in the maturation of rRNA and is evolutionarily related to RNase P. Here, the authors present the 3.0 Å cryo-EM structure of the S. cerevisiae RNase MRP holoenzyme, a 450 kDa ribonucleoprotein complex and compare it with RNase P.
format article
author Anna Perederina
Di Li
Hyunwook Lee
Carol Bator
Igor Berezin
Susan L. Hafenstein
Andrey S. Krasilnikov
author_facet Anna Perederina
Di Li
Hyunwook Lee
Carol Bator
Igor Berezin
Susan L. Hafenstein
Andrey S. Krasilnikov
author_sort Anna Perederina
title Cryo-EM structure of catalytic ribonucleoprotein complex RNase MRP
title_short Cryo-EM structure of catalytic ribonucleoprotein complex RNase MRP
title_full Cryo-EM structure of catalytic ribonucleoprotein complex RNase MRP
title_fullStr Cryo-EM structure of catalytic ribonucleoprotein complex RNase MRP
title_full_unstemmed Cryo-EM structure of catalytic ribonucleoprotein complex RNase MRP
title_sort cryo-em structure of catalytic ribonucleoprotein complex rnase mrp
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/06c391967b3f4eb3af021d620c244d8d
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