Roles of Gut Bacteriophages in the Pathogenesis and Treatment of Inflammatory Bowel Disease

Inflammatory bowel disease (IBD), including Crohn’s disease and ulcerative colitis, are chronic, relapsing intestinal inflammatory disorders. Although the molecular mechanisms governing the pathogenesis of IBD are not completely clear, the main factors are presumed to be a complex interaction betwee...

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Autores principales:	Lingling Qv, Sunbing Mao, Yongjun Li, Jia Zhang, Lanjuan Li
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	inflammatory bowel disease (IBD) gut phage immune response pathogenesis therapeutic target Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/06c679a39d494648974053ed49ef259d
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spelling	oai:doaj.org-article:06c679a39d494648974053ed49ef259d2021-12-01T02:01:03ZRoles of Gut Bacteriophages in the Pathogenesis and Treatment of Inflammatory Bowel Disease2235-298810.3389/fcimb.2021.755650https://doaj.org/article/06c679a39d494648974053ed49ef259d2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcimb.2021.755650/fullhttps://doaj.org/toc/2235-2988Inflammatory bowel disease (IBD), including Crohn’s disease and ulcerative colitis, are chronic, relapsing intestinal inflammatory disorders. Although the molecular mechanisms governing the pathogenesis of IBD are not completely clear, the main factors are presumed to be a complex interaction between genetic predisposition, host immune response and environmental exposure, especially the intestinal microbiome. Currently, most studies have focused on the role of gut bacteria in the onset and development of IBD, whereas little attention has been paid to the enteroviruses. Among of them, viruses that infect prokaryotes, called bacteriophages (phages) occupy the majority (90%) in population. Moreover, several recent studies have reported the capability of regulating the bacterial population in the gut, and the direct and indirect influence on host immune response. The present review highlights the roles of gut phages in IBD pathogenesis and explores the potentiality of phages as a therapeutic target for IBD treatment.Lingling QvSunbing MaoYongjun LiJia ZhangLanjuan LiFrontiers Media S.A.articleinflammatory bowel disease (IBD)gut phageimmune responsepathogenesistherapeutic targetMicrobiologyQR1-502ENFrontiers in Cellular and Infection Microbiology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	inflammatory bowel disease (IBD) gut phage immune response pathogenesis therapeutic target Microbiology QR1-502
spellingShingle	inflammatory bowel disease (IBD) gut phage immune response pathogenesis therapeutic target Microbiology QR1-502 Lingling Qv Sunbing Mao Yongjun Li Jia Zhang Lanjuan Li Roles of Gut Bacteriophages in the Pathogenesis and Treatment of Inflammatory Bowel Disease
description	Inflammatory bowel disease (IBD), including Crohn’s disease and ulcerative colitis, are chronic, relapsing intestinal inflammatory disorders. Although the molecular mechanisms governing the pathogenesis of IBD are not completely clear, the main factors are presumed to be a complex interaction between genetic predisposition, host immune response and environmental exposure, especially the intestinal microbiome. Currently, most studies have focused on the role of gut bacteria in the onset and development of IBD, whereas little attention has been paid to the enteroviruses. Among of them, viruses that infect prokaryotes, called bacteriophages (phages) occupy the majority (90%) in population. Moreover, several recent studies have reported the capability of regulating the bacterial population in the gut, and the direct and indirect influence on host immune response. The present review highlights the roles of gut phages in IBD pathogenesis and explores the potentiality of phages as a therapeutic target for IBD treatment.
format	article
author	Lingling Qv Sunbing Mao Yongjun Li Jia Zhang Lanjuan Li
author_facet	Lingling Qv Sunbing Mao Yongjun Li Jia Zhang Lanjuan Li
author_sort	Lingling Qv
title	Roles of Gut Bacteriophages in the Pathogenesis and Treatment of Inflammatory Bowel Disease
title_short	Roles of Gut Bacteriophages in the Pathogenesis and Treatment of Inflammatory Bowel Disease
title_full	Roles of Gut Bacteriophages in the Pathogenesis and Treatment of Inflammatory Bowel Disease
title_fullStr	Roles of Gut Bacteriophages in the Pathogenesis and Treatment of Inflammatory Bowel Disease
title_full_unstemmed	Roles of Gut Bacteriophages in the Pathogenesis and Treatment of Inflammatory Bowel Disease
title_sort	roles of gut bacteriophages in the pathogenesis and treatment of inflammatory bowel disease
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/06c679a39d494648974053ed49ef259d
work_keys_str_mv	AT linglingqv rolesofgutbacteriophagesinthepathogenesisandtreatmentofinflammatoryboweldisease AT sunbingmao rolesofgutbacteriophagesinthepathogenesisandtreatmentofinflammatoryboweldisease AT yongjunli rolesofgutbacteriophagesinthepathogenesisandtreatmentofinflammatoryboweldisease AT jiazhang rolesofgutbacteriophagesinthepathogenesisandtreatmentofinflammatoryboweldisease AT lanjuanli rolesofgutbacteriophagesinthepathogenesisandtreatmentofinflammatoryboweldisease
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Roles of Gut Bacteriophages in the Pathogenesis and Treatment of Inflammatory Bowel Disease

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