Self-assembled rosette nanotubes encapsulate and slowly release dexamethasone

Yupeng Chen1,2, Shang Song2, Zhimin Yan3, Hicham Fenniri3, Thomas J Webster2,41Department of Chemistry, Brown University, Providence, RI, USA; 2School of Engineering, Brown University, Providence, RI, USA; 3National Institute for Nanotechnology and Department of Chemistry, University of Alberta, Edm...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Chen Y, Song S, Yan Z, Fenniri H, Webster TJ
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2011
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/06c96877e8d9417aa811c9925159755f
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:06c96877e8d9417aa811c9925159755f
record_format	dspace
spelling	oai:doaj.org-article:06c96877e8d9417aa811c9925159755f2021-12-02T02:01:53ZSelf-assembled rosette nanotubes encapsulate and slowly release dexamethasone1176-91141178-2013https://doaj.org/article/06c96877e8d9417aa811c9925159755f2011-05-01T00:00:00Zhttp://www.dovepress.com/self-assembled-rosette-nanotubes-encapsulate-and-slowly-release-dexame-a7485https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Yupeng Chen1,2, Shang Song2, Zhimin Yan3, Hicham Fenniri3, Thomas J Webster2,41Department of Chemistry, Brown University, Providence, RI, USA; 2School of Engineering, Brown University, Providence, RI, USA; 3National Institute for Nanotechnology and Department of Chemistry, University of Alberta, Edmonton, Alberta, Canada; 4Department of Orthopedics, Brown University, Providence, RI, USAAbstract: Rosette nanotubes (RNTs) are novel, self-assembled, biomimetic, synthetic drug delivery materials suitable for numerous medical applications. Because of their amphiphilic character and hollow architecture, RNTs can be used to encapsulate and deliver hydrophobic drugs otherwise difficult to deliver in biological systems. Another advantage of using RNTs for drug delivery is their biocompatibility, low cytotoxicity, and their ability to engender a favorable, biologically-inspired environment for cell adhesion and growth. In this study, a method to incorporate dexamethasone (DEX, an inflammatory and a bone growth promoting steroid) into RNTs was developed. The drug-loaded RNTs were characterized using diffusion ordered nuclear magnetic resonance spectroscopy (DOSY NMR) and UV-Vis spectroscopy. Results showed for the first time that DEX can be easily and quickly encapsulated into RNTs and released to promote osteoblast (bone-forming cell) functions over long periods of time. As a result, RNTs are presented as a novel material for the targeted delivery of hydrophobic drugs otherwise difficult to deliver.Keywords: nanotubes, drug delivery, self-assembly, physiological conditionsChen YSong SYan ZFenniri HWebster TJDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2011, Iss default, Pp 1035-1044 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Chen Y Song S Yan Z Fenniri H Webster TJ Self-assembled rosette nanotubes encapsulate and slowly release dexamethasone
description	Yupeng Chen1,2, Shang Song2, Zhimin Yan3, Hicham Fenniri3, Thomas J Webster2,41Department of Chemistry, Brown University, Providence, RI, USA; 2School of Engineering, Brown University, Providence, RI, USA; 3National Institute for Nanotechnology and Department of Chemistry, University of Alberta, Edmonton, Alberta, Canada; 4Department of Orthopedics, Brown University, Providence, RI, USAAbstract: Rosette nanotubes (RNTs) are novel, self-assembled, biomimetic, synthetic drug delivery materials suitable for numerous medical applications. Because of their amphiphilic character and hollow architecture, RNTs can be used to encapsulate and deliver hydrophobic drugs otherwise difficult to deliver in biological systems. Another advantage of using RNTs for drug delivery is their biocompatibility, low cytotoxicity, and their ability to engender a favorable, biologically-inspired environment for cell adhesion and growth. In this study, a method to incorporate dexamethasone (DEX, an inflammatory and a bone growth promoting steroid) into RNTs was developed. The drug-loaded RNTs were characterized using diffusion ordered nuclear magnetic resonance spectroscopy (DOSY NMR) and UV-Vis spectroscopy. Results showed for the first time that DEX can be easily and quickly encapsulated into RNTs and released to promote osteoblast (bone-forming cell) functions over long periods of time. As a result, RNTs are presented as a novel material for the targeted delivery of hydrophobic drugs otherwise difficult to deliver.Keywords: nanotubes, drug delivery, self-assembly, physiological conditions
format	article
author	Chen Y Song S Yan Z Fenniri H Webster TJ
author_facet	Chen Y Song S Yan Z Fenniri H Webster TJ
author_sort	Chen Y
title	Self-assembled rosette nanotubes encapsulate and slowly release dexamethasone
title_short	Self-assembled rosette nanotubes encapsulate and slowly release dexamethasone
title_full	Self-assembled rosette nanotubes encapsulate and slowly release dexamethasone
title_fullStr	Self-assembled rosette nanotubes encapsulate and slowly release dexamethasone
title_full_unstemmed	Self-assembled rosette nanotubes encapsulate and slowly release dexamethasone
title_sort	self-assembled rosette nanotubes encapsulate and slowly release dexamethasone
publisher	Dove Medical Press
publishDate	2011
url	https://doaj.org/article/06c96877e8d9417aa811c9925159755f
work_keys_str_mv	AT cheny selfassembledrosettenanotubesencapsulateandslowlyreleasedexamethasone AT songs selfassembledrosettenanotubesencapsulateandslowlyreleasedexamethasone AT yanz selfassembledrosettenanotubesencapsulateandslowlyreleasedexamethasone AT fennirih selfassembledrosettenanotubesencapsulateandslowlyreleasedexamethasone AT webstertj selfassembledrosettenanotubesencapsulateandslowlyreleasedexamethasone
_version_	1718402753678540800

Self-assembled rosette nanotubes encapsulate and slowly release dexamethasone

Ejemplares similares