Bilateral Breast Ochronosis: a Case Report

ABSTRACT: Ochronosis is a syndrome characterized by bluish black discoloration due to the deposition of polymerized products of homogentisic acid (HGA) in the connective tissues. The endogenous variety (alkaptonuria), is a rare autosomal recessive metabolic disorder. The disorder is manifested by de...

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Autores principales:	Fatema A.J. AbdulKarim, Safwat M. Ibrahim, Arnold AD Hill, Nadeem Ajmal
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Ochronosis Alkaptonuria Homogentisic acid Breast ochronosis Mastectomy Surgery RD1-811
Acceso en línea:	https://doaj.org/article/06cabf0603c142f4a4a1622d3102325d
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spelling	oai:doaj.org-article:06cabf0603c142f4a4a1622d3102325d2021-12-02T05:02:00ZBilateral Breast Ochronosis: a Case Report2352-587810.1016/j.jpra.2021.06.005https://doaj.org/article/06cabf0603c142f4a4a1622d3102325d2021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2352587821000590https://doaj.org/toc/2352-5878ABSTRACT: Ochronosis is a syndrome characterized by bluish black discoloration due to the deposition of polymerized products of homogentisic acid (HGA) in the connective tissues. The endogenous variety (alkaptonuria), is a rare autosomal recessive metabolic disorder. The disorder is manifested by deficiency of the enzyme homogentisate 1,2-dioxygenase. The characteristic of the condition is a triad of pigmentation of skin, cartilage, and sclera; ochronotic arthropathies and homogentisic aciduria (resulting in darkening of urine). More rarely, it may affect the breast. This rare and interesting case of a woman with ochronosis of both breasts and chest wall, prompted us to write this case report.Fatema A.J. AbdulKarimSafwat M. IbrahimArnold AD HillNadeem AjmalElsevierarticleOchronosisAlkaptonuriaHomogentisic acidBreast ochronosisMastectomySurgeryRD1-811ENJPRAS Open, Vol 30, Iss , Pp 23-28 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ochronosis Alkaptonuria Homogentisic acid Breast ochronosis Mastectomy Surgery RD1-811
spellingShingle	Ochronosis Alkaptonuria Homogentisic acid Breast ochronosis Mastectomy Surgery RD1-811 Fatema A.J. AbdulKarim Safwat M. Ibrahim Arnold AD Hill Nadeem Ajmal Bilateral Breast Ochronosis: a Case Report
description	ABSTRACT: Ochronosis is a syndrome characterized by bluish black discoloration due to the deposition of polymerized products of homogentisic acid (HGA) in the connective tissues. The endogenous variety (alkaptonuria), is a rare autosomal recessive metabolic disorder. The disorder is manifested by deficiency of the enzyme homogentisate 1,2-dioxygenase. The characteristic of the condition is a triad of pigmentation of skin, cartilage, and sclera; ochronotic arthropathies and homogentisic aciduria (resulting in darkening of urine). More rarely, it may affect the breast. This rare and interesting case of a woman with ochronosis of both breasts and chest wall, prompted us to write this case report.
format	article
author	Fatema A.J. AbdulKarim Safwat M. Ibrahim Arnold AD Hill Nadeem Ajmal
author_facet	Fatema A.J. AbdulKarim Safwat M. Ibrahim Arnold AD Hill Nadeem Ajmal
author_sort	Fatema A.J. AbdulKarim
title	Bilateral Breast Ochronosis: a Case Report
title_short	Bilateral Breast Ochronosis: a Case Report
title_full	Bilateral Breast Ochronosis: a Case Report
title_fullStr	Bilateral Breast Ochronosis: a Case Report
title_full_unstemmed	Bilateral Breast Ochronosis: a Case Report
title_sort	bilateral breast ochronosis: a case report
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/06cabf0603c142f4a4a1622d3102325d
work_keys_str_mv	AT fatemaajabdulkarim bilateralbreastochronosisacasereport AT safwatmibrahim bilateralbreastochronosisacasereport AT arnoldadhill bilateralbreastochronosisacasereport AT nadeemajmal bilateralbreastochronosisacasereport
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Bilateral Breast Ochronosis: a Case Report

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