Bacteroides fragilis polysaccharide A induces IL-10 secreting B and T cells that prevent viral encephalitis

The capsular polysaccharide A (PSA) of Bacteroides fragilis is known to have immunomodulatory capability during sterile inflammatory disorders. Here Ramakrishna and colleagues show that PSA administration in a murine model of herpes simplex encephalitis induces IL-10 producing B and T cell populatio...

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Autores principales:	Chandran Ramakrishna, Maciej Kujawski, Hiutung Chu, Lin Li, Sarkis K. Mazmanian, Edouard M. Cantin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/06cd0a875a0147d49141e387d33bfbd5
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spelling	oai:doaj.org-article:06cd0a875a0147d49141e387d33bfbd52021-12-02T17:02:01ZBacteroides fragilis polysaccharide A induces IL-10 secreting B and T cells that prevent viral encephalitis10.1038/s41467-019-09884-62041-1723https://doaj.org/article/06cd0a875a0147d49141e387d33bfbd52019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09884-6https://doaj.org/toc/2041-1723The capsular polysaccharide A (PSA) of Bacteroides fragilis is known to have immunomodulatory capability during sterile inflammatory disorders. Here Ramakrishna and colleagues show that PSA administration in a murine model of herpes simplex encephalitis induces IL-10 producing B and T cell populations that confer protection against lethal challenge and brain pathology.Chandran RamakrishnaMaciej KujawskiHiutung ChuLin LiSarkis K. MazmanianEdouard M. CantinNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chandran Ramakrishna Maciej Kujawski Hiutung Chu Lin Li Sarkis K. Mazmanian Edouard M. Cantin Bacteroides fragilis polysaccharide A induces IL-10 secreting B and T cells that prevent viral encephalitis
description	The capsular polysaccharide A (PSA) of Bacteroides fragilis is known to have immunomodulatory capability during sterile inflammatory disorders. Here Ramakrishna and colleagues show that PSA administration in a murine model of herpes simplex encephalitis induces IL-10 producing B and T cell populations that confer protection against lethal challenge and brain pathology.
format	article
author	Chandran Ramakrishna Maciej Kujawski Hiutung Chu Lin Li Sarkis K. Mazmanian Edouard M. Cantin
author_facet	Chandran Ramakrishna Maciej Kujawski Hiutung Chu Lin Li Sarkis K. Mazmanian Edouard M. Cantin
author_sort	Chandran Ramakrishna
title	Bacteroides fragilis polysaccharide A induces IL-10 secreting B and T cells that prevent viral encephalitis
title_short	Bacteroides fragilis polysaccharide A induces IL-10 secreting B and T cells that prevent viral encephalitis
title_full	Bacteroides fragilis polysaccharide A induces IL-10 secreting B and T cells that prevent viral encephalitis
title_fullStr	Bacteroides fragilis polysaccharide A induces IL-10 secreting B and T cells that prevent viral encephalitis
title_full_unstemmed	Bacteroides fragilis polysaccharide A induces IL-10 secreting B and T cells that prevent viral encephalitis
title_sort	bacteroides fragilis polysaccharide a induces il-10 secreting b and t cells that prevent viral encephalitis
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/06cd0a875a0147d49141e387d33bfbd5
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Bacteroides fragilis polysaccharide A induces IL-10 secreting B and T cells that prevent viral encephalitis

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