Association Between the SLC1A1 Glutamate Transporter Gene and Obsessive-Compulsive Disorder in the Chinese Han Population

Xing Huang,1 Jie Liu,2 Jinzhi Cong,3 Xinhua Zhang1 1Department of Psychology and Psychiatry, Medical College, Qingdao University, Qingdao, People’s Republic of China; 2Department of Psychiatry, Qingdao Mental Health Center, Qingdao, People’s Republic of China; 3Health Convergence...

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Autores principales:	Huang X, Liu J, Cong J, Zhang X
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	obsessive-compulsive disorder glutamate transporter gene haplotype Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/06cec41cb6814324ab5368a55b8669b4
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spelling	oai:doaj.org-article:06cec41cb6814324ab5368a55b8669b42021-12-02T12:14:52ZAssociation Between the SLC1A1 Glutamate Transporter Gene and Obsessive-Compulsive Disorder in the Chinese Han Population1178-2021https://doaj.org/article/06cec41cb6814324ab5368a55b8669b42021-02-01T00:00:00Zhttps://www.dovepress.com/association-between-the-slc1a1-glutamate-transporter-gene-and-obsessiv-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Xing Huang,1 Jie Liu,2 Jinzhi Cong,3 Xinhua Zhang1 1Department of Psychology and Psychiatry, Medical College, Qingdao University, Qingdao, People’s Republic of China; 2Department of Psychiatry, Qingdao Mental Health Center, Qingdao, People’s Republic of China; 3Health Convergence Media Communication Division, Shandong Health Publicity and Education Center, Jinan, People’s Republic of ChinaCorrespondence: Xinhua ZhangDepartment of Psychology and Psychiatry, Medical College, Qingdao University, 38 Dengzhou Road, Qingdao, 266021, People’s Republic of ChinaTel +86 532 8279 0547Fax +86 532 8291 1385Email xhzhang87@126.comBackground: Obsessive-compulsive disorder (OCD) is a common, serious and genetically related mental illness; the etiology of OCD has not yet reached a definitive conclusion. Multiple evidence suggests that the glutamatergic system plays a major role in the pathophysiology of OCD. However, subsequent studies on the glutamate transporter gene are not consistent. OCD is a heterogeneous disease. To resolve the complex genetic basis of OCD, division the disorder into different subphenotypes is an effective method for studying the pathogenesis of OCD.Methods: We recruited 438 OCD patients and 465 age- and sex-matched controls from a Chinese Han population. rs10491734, rs3780412, rs301434 and rs3087879 SNPs were genotyped by real-time TaqMan polymerase chain reaction, and the chi-squared test was used to compare allele and genotype frequencies of variants between the two groups.Results: The genotype of rs301434 was statistically significant in total patients with OCD and the controls. After grouping by age and gender, the genotype of rs301434 was statistically significant in early-onset OCD, late-onset OCD as well as male OCD, the allele and genotype of rs3780412 was associated with late-onset OCD. Haplotype analysis showed that four loci haplotypes (G-A-A-G and G-G-A-G) were associated with total OCD, (G-G-A-G) was associated with female OCD, (G-A-G-G) was associated with male OCD, (G-A-A-G and G-G-A-G) were associated with late-onset OCD.Conclusion: This study provides suggestive evidence that SLC1A1 may be involved in the development of OCD in the Han population. However, these findings require further replication.Keywords: obsessive-compulsive disorder, glutamate transporter gene, haplotypeHuang XLiu JCong JZhang XDove Medical Pressarticleobsessive-compulsive disorderglutamate transporter genehaplotypeNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 17, Pp 347-354 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	obsessive-compulsive disorder glutamate transporter gene haplotype Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	obsessive-compulsive disorder glutamate transporter gene haplotype Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Huang X Liu J Cong J Zhang X Association Between the SLC1A1 Glutamate Transporter Gene and Obsessive-Compulsive Disorder in the Chinese Han Population
description	Xing Huang,1 Jie Liu,2 Jinzhi Cong,3 Xinhua Zhang1 1Department of Psychology and Psychiatry, Medical College, Qingdao University, Qingdao, People’s Republic of China; 2Department of Psychiatry, Qingdao Mental Health Center, Qingdao, People’s Republic of China; 3Health Convergence Media Communication Division, Shandong Health Publicity and Education Center, Jinan, People’s Republic of ChinaCorrespondence: Xinhua ZhangDepartment of Psychology and Psychiatry, Medical College, Qingdao University, 38 Dengzhou Road, Qingdao, 266021, People’s Republic of ChinaTel +86 532 8279 0547Fax +86 532 8291 1385Email xhzhang87@126.comBackground: Obsessive-compulsive disorder (OCD) is a common, serious and genetically related mental illness; the etiology of OCD has not yet reached a definitive conclusion. Multiple evidence suggests that the glutamatergic system plays a major role in the pathophysiology of OCD. However, subsequent studies on the glutamate transporter gene are not consistent. OCD is a heterogeneous disease. To resolve the complex genetic basis of OCD, division the disorder into different subphenotypes is an effective method for studying the pathogenesis of OCD.Methods: We recruited 438 OCD patients and 465 age- and sex-matched controls from a Chinese Han population. rs10491734, rs3780412, rs301434 and rs3087879 SNPs were genotyped by real-time TaqMan polymerase chain reaction, and the chi-squared test was used to compare allele and genotype frequencies of variants between the two groups.Results: The genotype of rs301434 was statistically significant in total patients with OCD and the controls. After grouping by age and gender, the genotype of rs301434 was statistically significant in early-onset OCD, late-onset OCD as well as male OCD, the allele and genotype of rs3780412 was associated with late-onset OCD. Haplotype analysis showed that four loci haplotypes (G-A-A-G and G-G-A-G) were associated with total OCD, (G-G-A-G) was associated with female OCD, (G-A-G-G) was associated with male OCD, (G-A-A-G and G-G-A-G) were associated with late-onset OCD.Conclusion: This study provides suggestive evidence that SLC1A1 may be involved in the development of OCD in the Han population. However, these findings require further replication.Keywords: obsessive-compulsive disorder, glutamate transporter gene, haplotype
format	article
author	Huang X Liu J Cong J Zhang X
author_facet	Huang X Liu J Cong J Zhang X
author_sort	Huang X
title	Association Between the SLC1A1 Glutamate Transporter Gene and Obsessive-Compulsive Disorder in the Chinese Han Population
title_short	Association Between the SLC1A1 Glutamate Transporter Gene and Obsessive-Compulsive Disorder in the Chinese Han Population
title_full	Association Between the SLC1A1 Glutamate Transporter Gene and Obsessive-Compulsive Disorder in the Chinese Han Population
title_fullStr	Association Between the SLC1A1 Glutamate Transporter Gene and Obsessive-Compulsive Disorder in the Chinese Han Population
title_full_unstemmed	Association Between the SLC1A1 Glutamate Transporter Gene and Obsessive-Compulsive Disorder in the Chinese Han Population
title_sort	association between the slc1a1 glutamate transporter gene and obsessive-compulsive disorder in the chinese han population
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/06cec41cb6814324ab5368a55b8669b4
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Association Between the SLC1A1 Glutamate Transporter Gene and Obsessive-Compulsive Disorder in the Chinese Han Population

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