The Value of King's Score as a Predictor of Risk of Hepatocellular Carcinoma among Egyptian Patients with Hepatitis C Virus-Related Cirrhosis
Background: Hepatocellular carcinoma (HCC) is the fifth most prevalent cancer and the second leading cause of cancer-related deaths worldwide. Egypt is one of the African countries with a high incidence of HCC. The process of carcinogenesis in the liver, particularly in post-hepatitic necrosis, is r...
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Shiraz University of Medical Sciences
2021
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oai:doaj.org-article:06d4d9bda4994668aacb262e6d26acc12021-11-29T10:40:47ZThe Value of King's Score as a Predictor of Risk of Hepatocellular Carcinoma among Egyptian Patients with Hepatitis C Virus-Related Cirrhosis2008-67092008-668710.30476/mejc.2021.85341.1275https://doaj.org/article/06d4d9bda4994668aacb262e6d26acc12021-10-01T00:00:00Zhttps://mejc.sums.ac.ir/article_47525_d8ec4cba9149c1268f09ad2afc4ec664.pdfhttps://doaj.org/toc/2008-6709https://doaj.org/toc/2008-6687Background: Hepatocellular carcinoma (HCC) is the fifth most prevalent cancer and the second leading cause of cancer-related deaths worldwide. Egypt is one of the African countries with a high incidence of HCC. The process of carcinogenesis in the liver, particularly in post-hepatitic necrosis, is related to the severity of liver damage and fibrosis. The present study aimed to investigate the utility of King’s score to identify patients at higher risk of developing HCC among patients with hepatitis C virus-related cirrhosis. Method: 58 patients were included in this retrospective case-control study. They were divided into two groups; group I included 29 patients diagnosed with HCC and group II comprised 29 patients without HCC. King’s score was calculated for all the patients based on their pararmeters at the time of diagnosis and their records of one year prior to the diagnosis. Results: King’s score was significantly higher in group I, not only at the time of diagnosis (95.4±45.2 vs. 24.23±7.4, p <0.001), but also when calculated from the patients’ records a year before the diagnosis (70.4±41.8 vs. 17.46±8.2, p <0.001). Conclusion: King’s score can diagnose higher risk of developing HCC up to one year before the appearance of focal lesion.Ashraf MetwallyAmal JoudaShiraz University of Medical Sciencesarticleliver neoplasmscarcinomahepatocellularretrospective studycasecontrol studycarcinogensisNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENMiddle East Journal of Cancer , Vol 12, Iss 4, Pp 499-505 (2021) |
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liver neoplasms carcinoma hepatocellular retrospective study casecontrol study carcinogensis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 |
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liver neoplasms carcinoma hepatocellular retrospective study casecontrol study carcinogensis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Ashraf Metwally Amal Jouda The Value of King's Score as a Predictor of Risk of Hepatocellular Carcinoma among Egyptian Patients with Hepatitis C Virus-Related Cirrhosis |
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Background: Hepatocellular carcinoma (HCC) is the fifth most prevalent cancer and the second leading cause of cancer-related deaths worldwide. Egypt is one of the African countries with a high incidence of HCC. The process of carcinogenesis in the liver, particularly in post-hepatitic necrosis, is related to the severity of liver damage and fibrosis. The present study aimed to investigate the utility of King’s score to identify patients at higher risk of developing HCC among patients with hepatitis C virus-related cirrhosis. Method: 58 patients were included in this retrospective case-control study. They were divided into two groups; group I included 29 patients diagnosed with HCC and group II comprised 29 patients without HCC. King’s score was calculated for all the patients based on their pararmeters at the time of diagnosis and their records of one year prior to the diagnosis. Results: King’s score was significantly higher in group I, not only at the time of diagnosis (95.4±45.2 vs. 24.23±7.4, p <0.001), but also when calculated from the patients’ records a year before the diagnosis (70.4±41.8 vs. 17.46±8.2, p <0.001). Conclusion: King’s score can diagnose higher risk of developing HCC up to one year before the appearance of focal lesion. |
format |
article |
author |
Ashraf Metwally Amal Jouda |
author_facet |
Ashraf Metwally Amal Jouda |
author_sort |
Ashraf Metwally |
title |
The Value of King's Score as a Predictor of Risk of Hepatocellular Carcinoma among Egyptian Patients with Hepatitis C Virus-Related Cirrhosis |
title_short |
The Value of King's Score as a Predictor of Risk of Hepatocellular Carcinoma among Egyptian Patients with Hepatitis C Virus-Related Cirrhosis |
title_full |
The Value of King's Score as a Predictor of Risk of Hepatocellular Carcinoma among Egyptian Patients with Hepatitis C Virus-Related Cirrhosis |
title_fullStr |
The Value of King's Score as a Predictor of Risk of Hepatocellular Carcinoma among Egyptian Patients with Hepatitis C Virus-Related Cirrhosis |
title_full_unstemmed |
The Value of King's Score as a Predictor of Risk of Hepatocellular Carcinoma among Egyptian Patients with Hepatitis C Virus-Related Cirrhosis |
title_sort |
value of king's score as a predictor of risk of hepatocellular carcinoma among egyptian patients with hepatitis c virus-related cirrhosis |
publisher |
Shiraz University of Medical Sciences |
publishDate |
2021 |
url |
https://doaj.org/article/06d4d9bda4994668aacb262e6d26acc1 |
work_keys_str_mv |
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