The Value of King's Score as a Predictor of Risk of Hepatocellular Carcinoma among Egyptian Patients with Hepatitis C Virus-Related Cirrhosis

Background: Hepatocellular carcinoma (HCC) is the fifth most prevalent cancer and the second leading cause of cancer-related deaths worldwide. Egypt is one of the African countries with a high incidence of HCC. The process of carcinogenesis in the liver, particularly in post-hepatitic necrosis, is r...

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Autores principales: Ashraf Metwally, Amal Jouda
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Lenguaje:EN
Publicado: Shiraz University of Medical Sciences 2021
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spelling oai:doaj.org-article:06d4d9bda4994668aacb262e6d26acc12021-11-29T10:40:47ZThe Value of King's Score as a Predictor of Risk of Hepatocellular Carcinoma among Egyptian Patients with Hepatitis C Virus-Related Cirrhosis2008-67092008-668710.30476/mejc.2021.85341.1275https://doaj.org/article/06d4d9bda4994668aacb262e6d26acc12021-10-01T00:00:00Zhttps://mejc.sums.ac.ir/article_47525_d8ec4cba9149c1268f09ad2afc4ec664.pdfhttps://doaj.org/toc/2008-6709https://doaj.org/toc/2008-6687Background: Hepatocellular carcinoma (HCC) is the fifth most prevalent cancer and the second leading cause of cancer-related deaths worldwide. Egypt is one of the African countries with a high incidence of HCC. The process of carcinogenesis in the liver, particularly in post-hepatitic necrosis, is related to the severity of liver damage and fibrosis. The present study aimed to investigate the utility of King’s score to identify patients at higher risk of developing HCC among patients with hepatitis C virus-related cirrhosis. Method: 58 patients were included in this retrospective case-control study. They were divided into two groups; group I included 29 patients diagnosed with HCC and group II comprised 29 patients without HCC. King’s score was calculated for all the patients based on their pararmeters at the time of diagnosis and their records of one year prior to the diagnosis. Results: King’s score was significantly higher in group I, not only at the time of diagnosis (95.4±45.2 vs. 24.23±7.4, p <0.001), but also when calculated from the patients’ records a year before the diagnosis (70.4±41.8 vs. 17.46±8.2, p <0.001). Conclusion: King’s score can diagnose higher risk of developing HCC up to one year before the appearance of focal lesion.Ashraf MetwallyAmal JoudaShiraz University of Medical Sciencesarticleliver neoplasmscarcinomahepatocellularretrospective studycasecontrol studycarcinogensisNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENMiddle East Journal of Cancer , Vol 12, Iss 4, Pp 499-505 (2021)
institution DOAJ
collection DOAJ
language EN
topic liver neoplasms
carcinoma
hepatocellular
retrospective study
casecontrol study
carcinogensis
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
spellingShingle liver neoplasms
carcinoma
hepatocellular
retrospective study
casecontrol study
carcinogensis
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
Ashraf Metwally
Amal Jouda
The Value of King's Score as a Predictor of Risk of Hepatocellular Carcinoma among Egyptian Patients with Hepatitis C Virus-Related Cirrhosis
description Background: Hepatocellular carcinoma (HCC) is the fifth most prevalent cancer and the second leading cause of cancer-related deaths worldwide. Egypt is one of the African countries with a high incidence of HCC. The process of carcinogenesis in the liver, particularly in post-hepatitic necrosis, is related to the severity of liver damage and fibrosis. The present study aimed to investigate the utility of King’s score to identify patients at higher risk of developing HCC among patients with hepatitis C virus-related cirrhosis. Method: 58 patients were included in this retrospective case-control study. They were divided into two groups; group I included 29 patients diagnosed with HCC and group II comprised 29 patients without HCC. King’s score was calculated for all the patients based on their pararmeters at the time of diagnosis and their records of one year prior to the diagnosis. Results: King’s score was significantly higher in group I, not only at the time of diagnosis (95.4±45.2 vs. 24.23±7.4, p <0.001), but also when calculated from the patients’ records a year before the diagnosis (70.4±41.8 vs. 17.46±8.2, p <0.001). Conclusion: King’s score can diagnose higher risk of developing HCC up to one year before the appearance of focal lesion.
format article
author Ashraf Metwally
Amal Jouda
author_facet Ashraf Metwally
Amal Jouda
author_sort Ashraf Metwally
title The Value of King's Score as a Predictor of Risk of Hepatocellular Carcinoma among Egyptian Patients with Hepatitis C Virus-Related Cirrhosis
title_short The Value of King's Score as a Predictor of Risk of Hepatocellular Carcinoma among Egyptian Patients with Hepatitis C Virus-Related Cirrhosis
title_full The Value of King's Score as a Predictor of Risk of Hepatocellular Carcinoma among Egyptian Patients with Hepatitis C Virus-Related Cirrhosis
title_fullStr The Value of King's Score as a Predictor of Risk of Hepatocellular Carcinoma among Egyptian Patients with Hepatitis C Virus-Related Cirrhosis
title_full_unstemmed The Value of King's Score as a Predictor of Risk of Hepatocellular Carcinoma among Egyptian Patients with Hepatitis C Virus-Related Cirrhosis
title_sort value of king's score as a predictor of risk of hepatocellular carcinoma among egyptian patients with hepatitis c virus-related cirrhosis
publisher Shiraz University of Medical Sciences
publishDate 2021
url https://doaj.org/article/06d4d9bda4994668aacb262e6d26acc1
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