Inhibition of mTORC1 by lncRNA H19 via disrupting 4E-BP1/Raptor interaction in pituitary tumours

LncRNA H19 has been shown to be aberrantly expressed in different cancers. Here, the authors show that H19 lncRNA is downregulated in pituitary adenomas and H19 is able to impede pituitary tumorigenesis via disruption of 4E-BPB1 and Raptor interaction to inhibit the phosphorylation of 4E-BP1.

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Autores principales:	Ze Rui Wu, Lichong Yan, Yan Ting Liu, Lei Cao, Yu Hang Guo, Yong Zhang, Hong Yao, Lin Cai, Han Bing Shang, Wei Wei Rui, Gang Yang, Xiao Biao Zhang, Hao Tang, Yu Wang, Jin Yan Huang, Yong Xu Wei, Wei Guo Zhao, Bing Su, Zhe Bao Wu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/06d60b35e5174563a00cf014ab758ffe
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spelling	oai:doaj.org-article:06d60b35e5174563a00cf014ab758ffe2021-12-02T14:40:55ZInhibition of mTORC1 by lncRNA H19 via disrupting 4E-BP1/Raptor interaction in pituitary tumours10.1038/s41467-018-06853-32041-1723https://doaj.org/article/06d60b35e5174563a00cf014ab758ffe2018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06853-3https://doaj.org/toc/2041-1723LncRNA H19 has been shown to be aberrantly expressed in different cancers. Here, the authors show that H19 lncRNA is downregulated in pituitary adenomas and H19 is able to impede pituitary tumorigenesis via disruption of 4E-BPB1 and Raptor interaction to inhibit the phosphorylation of 4E-BP1.Ze Rui WuLichong YanYan Ting LiuLei CaoYu Hang GuoYong ZhangHong YaoLin CaiHan Bing ShangWei Wei RuiGang YangXiao Biao ZhangHao TangYu WangJin Yan HuangYong Xu WeiWei Guo ZhaoBing SuZhe Bao WuNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ze Rui Wu Lichong Yan Yan Ting Liu Lei Cao Yu Hang Guo Yong Zhang Hong Yao Lin Cai Han Bing Shang Wei Wei Rui Gang Yang Xiao Biao Zhang Hao Tang Yu Wang Jin Yan Huang Yong Xu Wei Wei Guo Zhao Bing Su Zhe Bao Wu Inhibition of mTORC1 by lncRNA H19 via disrupting 4E-BP1/Raptor interaction in pituitary tumours
description	LncRNA H19 has been shown to be aberrantly expressed in different cancers. Here, the authors show that H19 lncRNA is downregulated in pituitary adenomas and H19 is able to impede pituitary tumorigenesis via disruption of 4E-BPB1 and Raptor interaction to inhibit the phosphorylation of 4E-BP1.
format	article
author	Ze Rui Wu Lichong Yan Yan Ting Liu Lei Cao Yu Hang Guo Yong Zhang Hong Yao Lin Cai Han Bing Shang Wei Wei Rui Gang Yang Xiao Biao Zhang Hao Tang Yu Wang Jin Yan Huang Yong Xu Wei Wei Guo Zhao Bing Su Zhe Bao Wu
author_facet	Ze Rui Wu Lichong Yan Yan Ting Liu Lei Cao Yu Hang Guo Yong Zhang Hong Yao Lin Cai Han Bing Shang Wei Wei Rui Gang Yang Xiao Biao Zhang Hao Tang Yu Wang Jin Yan Huang Yong Xu Wei Wei Guo Zhao Bing Su Zhe Bao Wu
author_sort	Ze Rui Wu
title	Inhibition of mTORC1 by lncRNA H19 via disrupting 4E-BP1/Raptor interaction in pituitary tumours
title_short	Inhibition of mTORC1 by lncRNA H19 via disrupting 4E-BP1/Raptor interaction in pituitary tumours
title_full	Inhibition of mTORC1 by lncRNA H19 via disrupting 4E-BP1/Raptor interaction in pituitary tumours
title_fullStr	Inhibition of mTORC1 by lncRNA H19 via disrupting 4E-BP1/Raptor interaction in pituitary tumours
title_full_unstemmed	Inhibition of mTORC1 by lncRNA H19 via disrupting 4E-BP1/Raptor interaction in pituitary tumours
title_sort	inhibition of mtorc1 by lncrna h19 via disrupting 4e-bp1/raptor interaction in pituitary tumours
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/06d60b35e5174563a00cf014ab758ffe
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Inhibition of mTORC1 by lncRNA H19 via disrupting 4E-BP1/Raptor interaction in pituitary tumours

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