Identification of long non-coding RNAs in two anthozoan species and their possible implications for coral bleaching

Abstract Long non-coding RNAs (lncRNAs) have been shown to play regulatory roles in a diverse range of biological processes and are associated with the outcomes of various diseases. The majority of studies about lncRNAs focus on model organisms, with lessened investigation in non-model organisms to...

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Autores principales:	Chen Huang, Jean-Étienne R. L. Morlighem, Jing Cai, Qiwen Liao, Carlos Daniel Perez, Paula Braga Gomes, Min Guo, Gandhi Rádis-Baptista, Simon Ming-Yuen Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/06d6a4b1b28d48a0834b371baa38f80e
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spelling	oai:doaj.org-article:06d6a4b1b28d48a0834b371baa38f80e2021-12-02T15:06:20ZIdentification of long non-coding RNAs in two anthozoan species and their possible implications for coral bleaching10.1038/s41598-017-02561-y2045-2322https://doaj.org/article/06d6a4b1b28d48a0834b371baa38f80e2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-02561-yhttps://doaj.org/toc/2045-2322Abstract Long non-coding RNAs (lncRNAs) have been shown to play regulatory roles in a diverse range of biological processes and are associated with the outcomes of various diseases. The majority of studies about lncRNAs focus on model organisms, with lessened investigation in non-model organisms to date. Herein, we have undertaken an investigation on lncRNA in two zoanthids (cnidarian): Protolpalythoa varibilis and Palythoa caribaeorum. A total of 11,206 and 13,240 lncRNAs were detected in P. variabilis and P. caribaeorum transcriptome, respectively. Comparison using NONCODE database indicated that the majority of these lncRNAs is taxonomically species-restricted with no identifiable orthologs. Even so, we found cases in which short regions of P. caribaeorum’s lncRNAs were similar to vertebrate species’ lncRNAs, and could be associated with lncRNA conserved regulatory functions. Consequently, some high-confidence lncRNA-mRNA interactions were predicted based on such conserved regions, therefore revealing possible involvement of lncRNAs in posttranscriptional processing and regulation in anthozoans. Moreover, investigation of differentially expressed lncRNAs, in healthy colonies and colonial individuals undergoing natural bleaching, indicated that some up-regulated lncRNAs in P. caribaeorum could posttranscriptionally regulate the mRNAs encoding proteins of Ras-mediated signal transduction pathway and components of innate immune-system, which could contribute to the molecular response of coral bleaching.Chen HuangJean-Étienne R. L. MorlighemJing CaiQiwen LiaoCarlos Daniel PerezPaula Braga GomesMin GuoGandhi Rádis-BaptistaSimon Ming-Yuen LeeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-18 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Chen Huang Jean-Étienne R. L. Morlighem Jing Cai Qiwen Liao Carlos Daniel Perez Paula Braga Gomes Min Guo Gandhi Rádis-Baptista Simon Ming-Yuen Lee Identification of long non-coding RNAs in two anthozoan species and their possible implications for coral bleaching
description	Abstract Long non-coding RNAs (lncRNAs) have been shown to play regulatory roles in a diverse range of biological processes and are associated with the outcomes of various diseases. The majority of studies about lncRNAs focus on model organisms, with lessened investigation in non-model organisms to date. Herein, we have undertaken an investigation on lncRNA in two zoanthids (cnidarian): Protolpalythoa varibilis and Palythoa caribaeorum. A total of 11,206 and 13,240 lncRNAs were detected in P. variabilis and P. caribaeorum transcriptome, respectively. Comparison using NONCODE database indicated that the majority of these lncRNAs is taxonomically species-restricted with no identifiable orthologs. Even so, we found cases in which short regions of P. caribaeorum’s lncRNAs were similar to vertebrate species’ lncRNAs, and could be associated with lncRNA conserved regulatory functions. Consequently, some high-confidence lncRNA-mRNA interactions were predicted based on such conserved regions, therefore revealing possible involvement of lncRNAs in posttranscriptional processing and regulation in anthozoans. Moreover, investigation of differentially expressed lncRNAs, in healthy colonies and colonial individuals undergoing natural bleaching, indicated that some up-regulated lncRNAs in P. caribaeorum could posttranscriptionally regulate the mRNAs encoding proteins of Ras-mediated signal transduction pathway and components of innate immune-system, which could contribute to the molecular response of coral bleaching.
format	article
author	Chen Huang Jean-Étienne R. L. Morlighem Jing Cai Qiwen Liao Carlos Daniel Perez Paula Braga Gomes Min Guo Gandhi Rádis-Baptista Simon Ming-Yuen Lee
author_facet	Chen Huang Jean-Étienne R. L. Morlighem Jing Cai Qiwen Liao Carlos Daniel Perez Paula Braga Gomes Min Guo Gandhi Rádis-Baptista Simon Ming-Yuen Lee
author_sort	Chen Huang
title	Identification of long non-coding RNAs in two anthozoan species and their possible implications for coral bleaching
title_short	Identification of long non-coding RNAs in two anthozoan species and their possible implications for coral bleaching
title_full	Identification of long non-coding RNAs in two anthozoan species and their possible implications for coral bleaching
title_fullStr	Identification of long non-coding RNAs in two anthozoan species and their possible implications for coral bleaching
title_full_unstemmed	Identification of long non-coding RNAs in two anthozoan species and their possible implications for coral bleaching
title_sort	identification of long non-coding rnas in two anthozoan species and their possible implications for coral bleaching
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/06d6a4b1b28d48a0834b371baa38f80e
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Identification of long non-coding RNAs in two anthozoan species and their possible implications for coral bleaching

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