Evaluation of corneal symmetry after UV corneal crosslinking for keratoconus

Hanan Mofty,1,2 Khaled Alzahrani,2 Fiona Carley,3 Sophie Harper,3 Arun Brahma,3 Leon Au,3 Debbie Morley,3 M Chantal Hillarby2 1Optometry Department, College of Applied Medical Science, King Saud University, Riyadh, Kingdom of Saudi Arabia; 2Division of Pharmacy and Optometry, School of Health Scien...

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Autores principales:	Mofty H, Alzahrani K, Carley F, Harper S, Brahma A, Au L, Morley D, Hillarby MC
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	keratoconus cross linking topography corneal haze asphericity Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/06d79565fa494d27bee3306ce36df983
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spelling	oai:doaj.org-article:06d79565fa494d27bee3306ce36df9832021-12-02T02:06:54ZEvaluation of corneal symmetry after UV corneal crosslinking for keratoconus1177-5483https://doaj.org/article/06d79565fa494d27bee3306ce36df9832017-11-01T00:00:00Zhttps://www.dovepress.com/evaluation-of-corneal-symmetry-after-uv-corneal-crosslinking-for-kerat-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Hanan Mofty,1,2 Khaled Alzahrani,2 Fiona Carley,3 Sophie Harper,3 Arun Brahma,3 Leon Au,3 Debbie Morley,3 M Chantal Hillarby2 1Optometry Department, College of Applied Medical Science, King Saud University, Riyadh, Kingdom of Saudi Arabia; 2Division of Pharmacy and Optometry, School of Health Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, 3Manchester Royal Eye Hospital, Manchester, UK Purpose: The purpose of this study was to assess UV corneal crosslinking (CXL) treatment outcomes for keratoconus by evaluating the corneal regularity in patients through follow-up using the Oculus Pentacam.Patients and methods: A total of 18 eyes from CXL patients with keratoconus were studied before and after CXL treatment, and six eyes from six patients who were not treated with CXL served as controls. Treated patients had Pentacam images taken before CXL treatment and regularly 3 months post treatment up to the 12th month. Controls were imaged during their first appointment and after 12 months. Symmetry and asphericity were evaluated and correlated with both best-corrected visual acuity (BCVA) and maximum K-readings.Results: In the CXL-treated group, there was a significant improvement in the index of symmetrical variation (ISV) and keratoconus index (KI) at 3 months and in the index of height asymmetry (IHA) and minimum radius of curvature (Rmin) at 9 months post treatment. On the contrary, the untreated group’s indices showed some significant worsening in ISV, KI, central keratoconus index (CKI), and Rmin. A novel finding in our study was a slight positive shift of anterior asphericity in the 6 mm, 7 mm, and 8 mm 3 months after treatment, which had a correlation with BCVA (R2=0.390, p=0.053) and a strong correlation with maximum K-reading (R2=0.690, p=0.005). However, the untreated group had no significant changes after 1 year.Conclusion: The corneal asymmetrical shape is associated with the spherical aberration alteration influenced by temporal evolution of surface ablation and increased corneal haze. However, insignificant changes in symmetry attest the stabilization effect on cornea postoperatively as compared with controls. Keywords: keratoconus, crosslinking, topography, corneal haze, asphericityMofty HAlzahrani KCarley FHarper SBrahma AAu LMorley DHillarby MCDove Medical Pressarticlekeratoconuscross linkingtopographycorneal hazeasphericityOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 11, Pp 2043-2049 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	keratoconus cross linking topography corneal haze asphericity Ophthalmology RE1-994
spellingShingle	keratoconus cross linking topography corneal haze asphericity Ophthalmology RE1-994 Mofty H Alzahrani K Carley F Harper S Brahma A Au L Morley D Hillarby MC Evaluation of corneal symmetry after UV corneal crosslinking for keratoconus
description	Hanan Mofty,1,2 Khaled Alzahrani,2 Fiona Carley,3 Sophie Harper,3 Arun Brahma,3 Leon Au,3 Debbie Morley,3 M Chantal Hillarby2 1Optometry Department, College of Applied Medical Science, King Saud University, Riyadh, Kingdom of Saudi Arabia; 2Division of Pharmacy and Optometry, School of Health Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, 3Manchester Royal Eye Hospital, Manchester, UK Purpose: The purpose of this study was to assess UV corneal crosslinking (CXL) treatment outcomes for keratoconus by evaluating the corneal regularity in patients through follow-up using the Oculus Pentacam.Patients and methods: A total of 18 eyes from CXL patients with keratoconus were studied before and after CXL treatment, and six eyes from six patients who were not treated with CXL served as controls. Treated patients had Pentacam images taken before CXL treatment and regularly 3 months post treatment up to the 12th month. Controls were imaged during their first appointment and after 12 months. Symmetry and asphericity were evaluated and correlated with both best-corrected visual acuity (BCVA) and maximum K-readings.Results: In the CXL-treated group, there was a significant improvement in the index of symmetrical variation (ISV) and keratoconus index (KI) at 3 months and in the index of height asymmetry (IHA) and minimum radius of curvature (Rmin) at 9 months post treatment. On the contrary, the untreated group’s indices showed some significant worsening in ISV, KI, central keratoconus index (CKI), and Rmin. A novel finding in our study was a slight positive shift of anterior asphericity in the 6 mm, 7 mm, and 8 mm 3 months after treatment, which had a correlation with BCVA (R2=0.390, p=0.053) and a strong correlation with maximum K-reading (R2=0.690, p=0.005). However, the untreated group had no significant changes after 1 year.Conclusion: The corneal asymmetrical shape is associated with the spherical aberration alteration influenced by temporal evolution of surface ablation and increased corneal haze. However, insignificant changes in symmetry attest the stabilization effect on cornea postoperatively as compared with controls. Keywords: keratoconus, crosslinking, topography, corneal haze, asphericity
format	article
author	Mofty H Alzahrani K Carley F Harper S Brahma A Au L Morley D Hillarby MC
author_facet	Mofty H Alzahrani K Carley F Harper S Brahma A Au L Morley D Hillarby MC
author_sort	Mofty H
title	Evaluation of corneal symmetry after UV corneal crosslinking for keratoconus
title_short	Evaluation of corneal symmetry after UV corneal crosslinking for keratoconus
title_full	Evaluation of corneal symmetry after UV corneal crosslinking for keratoconus
title_fullStr	Evaluation of corneal symmetry after UV corneal crosslinking for keratoconus
title_full_unstemmed	Evaluation of corneal symmetry after UV corneal crosslinking for keratoconus
title_sort	evaluation of corneal symmetry after uv corneal crosslinking for keratoconus
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/06d79565fa494d27bee3306ce36df983
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_version_	1718402692505665536

Evaluation of corneal symmetry after UV corneal crosslinking for keratoconus

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