A systematic review and meta-analysis of angiotensin-converting enzyme inhibitor use and psoriasis incidence

Abstract Although a considerable volume of data supporting induction or aggravation of psoriasis because of angiotensin-converting enzyme (ACE) inhibitor use exists, it remains insufficient for definitive conclusions. Therefore, we aimed to evaluate the association between ACE inhibitor use and psor...

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Autores principales:	Gonjin Song, Ji Yea Kim, Ha Young Yoon, Jeong Yee, Hye Sun Gwak
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/06d982a4ce2f487d84650e6eac878820
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spelling	oai:doaj.org-article:06d982a4ce2f487d84650e6eac8788202021-12-02T14:35:40ZA systematic review and meta-analysis of angiotensin-converting enzyme inhibitor use and psoriasis incidence10.1038/s41598-021-89490-z2045-2322https://doaj.org/article/06d982a4ce2f487d84650e6eac8788202021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89490-zhttps://doaj.org/toc/2045-2322Abstract Although a considerable volume of data supporting induction or aggravation of psoriasis because of angiotensin-converting enzyme (ACE) inhibitor use exists, it remains insufficient for definitive conclusions. Therefore, we aimed to evaluate the association between ACE inhibitor use and psoriasis incidence through a systematic literature review and meta-analysis. We searched for qualifying studies across PubMed, Web of Science, and Embase. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to evaluate the strength of the association between ACE inhibitor use and psoriasis incidence. Eight studies with a total of 54,509 patients with a psoriasis diagnosis were included in this meta-analysis. The pooled OR for psoriasis incidence among ACE inhibitor users was 1.52 (95% CI, 1.16–2.00) compared to that among non-users. From subgroup analysis by continent, the OR for ACE inhibitor users versus non-users was 2.37 (95% CI 1.28–4.37) in Asia. Per the subgroup analysis by climate, the OR for ACE inhibitor users vs non-users in dry climate was 3.45 (95% CI: 2.05–5.79) vs 1.32 (95% CI 1.01–1.73) in temperate climate. Our results reveal a significant association between ACE inhibitor use and psoriasis incidence.Gonjin SongJi Yea KimHa Young YoonJeong YeeHye Sun GwakNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Gonjin Song Ji Yea Kim Ha Young Yoon Jeong Yee Hye Sun Gwak A systematic review and meta-analysis of angiotensin-converting enzyme inhibitor use and psoriasis incidence
description	Abstract Although a considerable volume of data supporting induction or aggravation of psoriasis because of angiotensin-converting enzyme (ACE) inhibitor use exists, it remains insufficient for definitive conclusions. Therefore, we aimed to evaluate the association between ACE inhibitor use and psoriasis incidence through a systematic literature review and meta-analysis. We searched for qualifying studies across PubMed, Web of Science, and Embase. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to evaluate the strength of the association between ACE inhibitor use and psoriasis incidence. Eight studies with a total of 54,509 patients with a psoriasis diagnosis were included in this meta-analysis. The pooled OR for psoriasis incidence among ACE inhibitor users was 1.52 (95% CI, 1.16–2.00) compared to that among non-users. From subgroup analysis by continent, the OR for ACE inhibitor users versus non-users was 2.37 (95% CI 1.28–4.37) in Asia. Per the subgroup analysis by climate, the OR for ACE inhibitor users vs non-users in dry climate was 3.45 (95% CI: 2.05–5.79) vs 1.32 (95% CI 1.01–1.73) in temperate climate. Our results reveal a significant association between ACE inhibitor use and psoriasis incidence.
format	article
author	Gonjin Song Ji Yea Kim Ha Young Yoon Jeong Yee Hye Sun Gwak
author_facet	Gonjin Song Ji Yea Kim Ha Young Yoon Jeong Yee Hye Sun Gwak
author_sort	Gonjin Song
title	A systematic review and meta-analysis of angiotensin-converting enzyme inhibitor use and psoriasis incidence
title_short	A systematic review and meta-analysis of angiotensin-converting enzyme inhibitor use and psoriasis incidence
title_full	A systematic review and meta-analysis of angiotensin-converting enzyme inhibitor use and psoriasis incidence
title_fullStr	A systematic review and meta-analysis of angiotensin-converting enzyme inhibitor use and psoriasis incidence
title_full_unstemmed	A systematic review and meta-analysis of angiotensin-converting enzyme inhibitor use and psoriasis incidence
title_sort	systematic review and meta-analysis of angiotensin-converting enzyme inhibitor use and psoriasis incidence
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/06d982a4ce2f487d84650e6eac878820
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A systematic review and meta-analysis of angiotensin-converting enzyme inhibitor use and psoriasis incidence

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