Neuregulin 1 improves complex 2-mediated mitochondrial respiration in skeletal muscle of healthy and diabetic mice

Abstract It has been reported that neuregulin1 (NRG1) improves glucose tolerance in healthy and diabetic rodents. In vitro studies also suggest that NRG1 regulates myocyte oxidative capacity. To confirm this observation in vivo, we evaluated the effect on mitochondrial function of an 8-week treatmen...

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Autores principales:	Gaël Ennequin, Frederic Capel, Kevin Caillaud, Vivien Chavanelle, Monique Etienne, Allison Teixeira, Xinyan Li, Nathalie Boisseau, Pascal Sirvent
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/06d9d08b178b4e84a5f2021f035d8321
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spelling	oai:doaj.org-article:06d9d08b178b4e84a5f2021f035d83212021-12-02T11:40:58ZNeuregulin 1 improves complex 2-mediated mitochondrial respiration in skeletal muscle of healthy and diabetic mice10.1038/s41598-017-02029-z2045-2322https://doaj.org/article/06d9d08b178b4e84a5f2021f035d83212017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-02029-zhttps://doaj.org/toc/2045-2322Abstract It has been reported that neuregulin1 (NRG1) improves glucose tolerance in healthy and diabetic rodents. In vitro studies also suggest that NRG1 regulates myocyte oxidative capacity. To confirm this observation in vivo, we evaluated the effect on mitochondrial function of an 8-week treatment with NRG1 in db/db diabetic mice and C57BL/6JRJ healthy controls. NRG1 treatment improved complex 2-mediated mitochondrial respiration in the gastrocnemius of both control and diabetic mice and increased mitochondrial complex 2 subunit content by 2-fold. This effect was not associated with an increase in mitochondrial biogenesis markers. Enhanced ERBB4 phosphorylation could mediate NRG1 effects on mitochondrial function through signalling pathways, independently of ERK1/2, AKT or AMPK.Gaël EnnequinFrederic CapelKevin CaillaudVivien ChavanelleMonique EtienneAllison TeixeiraXinyan LiNathalie BoisseauPascal SirventNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Gaël Ennequin Frederic Capel Kevin Caillaud Vivien Chavanelle Monique Etienne Allison Teixeira Xinyan Li Nathalie Boisseau Pascal Sirvent Neuregulin 1 improves complex 2-mediated mitochondrial respiration in skeletal muscle of healthy and diabetic mice
description	Abstract It has been reported that neuregulin1 (NRG1) improves glucose tolerance in healthy and diabetic rodents. In vitro studies also suggest that NRG1 regulates myocyte oxidative capacity. To confirm this observation in vivo, we evaluated the effect on mitochondrial function of an 8-week treatment with NRG1 in db/db diabetic mice and C57BL/6JRJ healthy controls. NRG1 treatment improved complex 2-mediated mitochondrial respiration in the gastrocnemius of both control and diabetic mice and increased mitochondrial complex 2 subunit content by 2-fold. This effect was not associated with an increase in mitochondrial biogenesis markers. Enhanced ERBB4 phosphorylation could mediate NRG1 effects on mitochondrial function through signalling pathways, independently of ERK1/2, AKT or AMPK.
format	article
author	Gaël Ennequin Frederic Capel Kevin Caillaud Vivien Chavanelle Monique Etienne Allison Teixeira Xinyan Li Nathalie Boisseau Pascal Sirvent
author_facet	Gaël Ennequin Frederic Capel Kevin Caillaud Vivien Chavanelle Monique Etienne Allison Teixeira Xinyan Li Nathalie Boisseau Pascal Sirvent
author_sort	Gaël Ennequin
title	Neuregulin 1 improves complex 2-mediated mitochondrial respiration in skeletal muscle of healthy and diabetic mice
title_short	Neuregulin 1 improves complex 2-mediated mitochondrial respiration in skeletal muscle of healthy and diabetic mice
title_full	Neuregulin 1 improves complex 2-mediated mitochondrial respiration in skeletal muscle of healthy and diabetic mice
title_fullStr	Neuregulin 1 improves complex 2-mediated mitochondrial respiration in skeletal muscle of healthy and diabetic mice
title_full_unstemmed	Neuregulin 1 improves complex 2-mediated mitochondrial respiration in skeletal muscle of healthy and diabetic mice
title_sort	neuregulin 1 improves complex 2-mediated mitochondrial respiration in skeletal muscle of healthy and diabetic mice
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/06d9d08b178b4e84a5f2021f035d8321
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Neuregulin 1 improves complex 2-mediated mitochondrial respiration in skeletal muscle of healthy and diabetic mice

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