Restoring heart function and electrical integrity: closing the circuit

Abstract Cardiovascular diseases are the main cause of death in the world and are often associated with the occurrence of arrhythmias due to disruption of myocardial electrical integrity. Pathologies involving dysfunction of the specialized cardiac excitatory/conductive tissue are also common and co...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Luís Miguel Monteiro, Francisco Vasques-Nóvoa, Lino Ferreira, Perpétua Pinto-do-Ó, Diana Santos Nascimento
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R
Acceso en línea:	https://doaj.org/article/06ddde401f7341e99240df4358c62858
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:06ddde401f7341e99240df4358c62858
record_format	dspace
spelling	oai:doaj.org-article:06ddde401f7341e99240df4358c628582021-12-02T14:22:13ZRestoring heart function and electrical integrity: closing the circuit10.1038/s41536-017-0015-22057-3995https://doaj.org/article/06ddde401f7341e99240df4358c628582017-04-01T00:00:00Zhttps://doi.org/10.1038/s41536-017-0015-2https://doaj.org/toc/2057-3995Abstract Cardiovascular diseases are the main cause of death in the world and are often associated with the occurrence of arrhythmias due to disruption of myocardial electrical integrity. Pathologies involving dysfunction of the specialized cardiac excitatory/conductive tissue are also common and constitute an added source of morbidity and mortality since current standard therapies withstand a great number of limitations. As electrical integrity is essential for a well-functioning heart, innovative strategies have been bioengineered to improve heart conduction and/or promote myocardial repair, based on: (1) gene and/or cell delivery; or (2) conductive biomaterials as tools for cardiac tissue engineering. Herein we aim to review the state-of-art in the area, while briefly describing the biological principles underlying the heart electrical/conduction system and how this system can be disrupted in heart disease. Suggestions regarding targets for future studies are also presented.Luís Miguel MonteiroFrancisco Vasques-NóvoaLino FerreiraPerpétua Pinto-do-ÓDiana Santos NascimentoNature PortfolioarticleMedicineRENnpj Regenerative Medicine, Vol 2, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R
spellingShingle	Medicine R Luís Miguel Monteiro Francisco Vasques-Nóvoa Lino Ferreira Perpétua Pinto-do-Ó Diana Santos Nascimento Restoring heart function and electrical integrity: closing the circuit
description	Abstract Cardiovascular diseases are the main cause of death in the world and are often associated with the occurrence of arrhythmias due to disruption of myocardial electrical integrity. Pathologies involving dysfunction of the specialized cardiac excitatory/conductive tissue are also common and constitute an added source of morbidity and mortality since current standard therapies withstand a great number of limitations. As electrical integrity is essential for a well-functioning heart, innovative strategies have been bioengineered to improve heart conduction and/or promote myocardial repair, based on: (1) gene and/or cell delivery; or (2) conductive biomaterials as tools for cardiac tissue engineering. Herein we aim to review the state-of-art in the area, while briefly describing the biological principles underlying the heart electrical/conduction system and how this system can be disrupted in heart disease. Suggestions regarding targets for future studies are also presented.
format	article
author	Luís Miguel Monteiro Francisco Vasques-Nóvoa Lino Ferreira Perpétua Pinto-do-Ó Diana Santos Nascimento
author_facet	Luís Miguel Monteiro Francisco Vasques-Nóvoa Lino Ferreira Perpétua Pinto-do-Ó Diana Santos Nascimento
author_sort	Luís Miguel Monteiro
title	Restoring heart function and electrical integrity: closing the circuit
title_short	Restoring heart function and electrical integrity: closing the circuit
title_full	Restoring heart function and electrical integrity: closing the circuit
title_fullStr	Restoring heart function and electrical integrity: closing the circuit
title_full_unstemmed	Restoring heart function and electrical integrity: closing the circuit
title_sort	restoring heart function and electrical integrity: closing the circuit
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/06ddde401f7341e99240df4358c62858
work_keys_str_mv	AT luismiguelmonteiro restoringheartfunctionandelectricalintegrityclosingthecircuit AT franciscovasquesnovoa restoringheartfunctionandelectricalintegrityclosingthecircuit AT linoferreira restoringheartfunctionandelectricalintegrityclosingthecircuit AT perpetuapintodoo restoringheartfunctionandelectricalintegrityclosingthecircuit AT dianasantosnascimento restoringheartfunctionandelectricalintegrityclosingthecircuit
_version_	1718391466900848640

Restoring heart function and electrical integrity: closing the circuit

Ejemplares similares