Thymic iNKT single cell analyses unmask the common developmental program of mouse innate T cells

Innate-like T cells such as invariant natural killer T (iNKT) and mucosal-associated invariant T (MAIT) cells both develop in the thymus. Here the authors use single-cell RNA sequencing to show that mouse iNKT and MAIT share components of developmental regulation, with a transcription factor, Hivep3...

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Autores principales:	S. Harsha Krovi, Jingjing Zhang, Mary Jessamine Michaels-Foster, Tonya Brunetti, Liyen Loh, James Scott-Browne, Laurent Gapin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/06e13866d71d4727a0acfddef21305ab
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spelling	oai:doaj.org-article:06e13866d71d4727a0acfddef21305ab2021-12-02T14:16:24ZThymic iNKT single cell analyses unmask the common developmental program of mouse innate T cells10.1038/s41467-020-20073-82041-1723https://doaj.org/article/06e13866d71d4727a0acfddef21305ab2020-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20073-8https://doaj.org/toc/2041-1723Innate-like T cells such as invariant natural killer T (iNKT) and mucosal-associated invariant T (MAIT) cells both develop in the thymus. Here the authors use single-cell RNA sequencing to show that mouse iNKT and MAIT share components of developmental regulation, with a transcription factor, Hivep3, implicated for the maturation of both cell types.S. Harsha KroviJingjing ZhangMary Jessamine Michaels-FosterTonya BrunettiLiyen LohJames Scott-BrowneLaurent GapinNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q S. Harsha Krovi Jingjing Zhang Mary Jessamine Michaels-Foster Tonya Brunetti Liyen Loh James Scott-Browne Laurent Gapin Thymic iNKT single cell analyses unmask the common developmental program of mouse innate T cells
description	Innate-like T cells such as invariant natural killer T (iNKT) and mucosal-associated invariant T (MAIT) cells both develop in the thymus. Here the authors use single-cell RNA sequencing to show that mouse iNKT and MAIT share components of developmental regulation, with a transcription factor, Hivep3, implicated for the maturation of both cell types.
format	article
author	S. Harsha Krovi Jingjing Zhang Mary Jessamine Michaels-Foster Tonya Brunetti Liyen Loh James Scott-Browne Laurent Gapin
author_facet	S. Harsha Krovi Jingjing Zhang Mary Jessamine Michaels-Foster Tonya Brunetti Liyen Loh James Scott-Browne Laurent Gapin
author_sort	S. Harsha Krovi
title	Thymic iNKT single cell analyses unmask the common developmental program of mouse innate T cells
title_short	Thymic iNKT single cell analyses unmask the common developmental program of mouse innate T cells
title_full	Thymic iNKT single cell analyses unmask the common developmental program of mouse innate T cells
title_fullStr	Thymic iNKT single cell analyses unmask the common developmental program of mouse innate T cells
title_full_unstemmed	Thymic iNKT single cell analyses unmask the common developmental program of mouse innate T cells
title_sort	thymic inkt single cell analyses unmask the common developmental program of mouse innate t cells
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/06e13866d71d4727a0acfddef21305ab
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Thymic iNKT single cell analyses unmask the common developmental program of mouse innate T cells

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